A Shared Genetic Mechanism for Melanotic Encapsulation of CM–Sephadex Beads and a Malaria Parasite,Plasmodium cynomolgiB, in the Mosquito,Anopheles gambiae

1996 ◽  
Vol 84 (3) ◽  
pp. 380-386 ◽  
Author(s):  
M.J. Gorman ◽  
A.J. Cornel ◽  
F.H. Collins ◽  
S.M. Paskewitz
Keyword(s):  
Anopheles Gambiae ◽  
Malaria Parasite ◽  
Genetic Mechanism ◽  
Parasite Plasmodium ◽  
Mosquito Anopheles Gambiae ◽  
Melanotic Encapsulation ◽  
Shared Genetic

scholarly journals Anopheles gambiae APL1 Is a Family of Variable LRR Proteins Required for Rel1-Mediated Protection from the Malaria Parasite, Plasmodium berghei

PLoS ONE ◽  
2008 ◽  
Vol 3 (11) ◽  
pp. e3672 ◽  
Author(s):  
Michelle M. Riehle ◽  
Jiannong Xu ◽  
Brian P. Lazzaro ◽  
Susan M. Rottschaefer ◽  
Boubacar Coulibaly ◽  
...  
Keyword(s):  
Anopheles Gambiae ◽  
Plasmodium Berghei ◽  
Malaria Parasite ◽  
Parasite Plasmodium

scholarly journals microRNA tissue atlas of the malaria mosquito Anopheles gambiae

2017 ◽  
Author(s):  
Lena Lampe ◽  
Elena A. Levashina
Keyword(s):  
Plasmodium Falciparum ◽  
Anopheles Gambiae ◽  
Mirna Expression ◽  
Blood Meal ◽  
Life Style ◽  
Malaria Parasite ◽  
Malaria Mosquito ◽  
Human Malaria Parasite ◽  
Mosquito Anopheles Gambiae ◽  
Blood Meal Digestion

ABSTRACTAnopheles gambiae mosquitoes transmit the human malaria parasite Plasmodium falciparum, which causes the majority of fatal malaria cases worldwide. The hematophagous life style defines the mosquito reproductive biology and is exploited by P. falciparum for its own sexual reproduction and transmission. The two main phases of the mosquito reproductive cycle, pre-vitellogenic (PV) and post-blood meal (PBM) shape its capacity to transmit malaria. Transition between these phases is tightly coordinated to ensure homeostasis between mosquito tissues and successful reproduction. One layer of control is provided by microRNAs, well known regulators of blood meal digestion and egg development in Aedes mosquitoes. Here, we report a global overview of tissue-specific miRNA expression during the PV and PBM phases and identify miRNAs regulated during PV to PBM transition. The observed coordinated changes in the expression levels of a set of miRNAs in the energy-storing tissues suggest a role in the regulation of blood meal-induced metabolic changes.

scholarly journals Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei

2009 ◽  
Vol 39 (5-6) ◽  
pp. 395-402 ◽  
Author(s):  
Mónica González-Lázaro ◽  
Rhoel R. Dinglasan ◽  
Fidel de la Cruz Hernández-Hernández ◽  
Mario Henry Rodríguez ◽  
Martin Laclaustra ◽  
...  
Keyword(s):  
Anopheles Gambiae ◽  
Expression Profile ◽  
Plasmodium Berghei ◽  
Malaria Parasite ◽  
Potential Interaction ◽  
Parasite Plasmodium

scholarly journals Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei

EMBO Reports ◽  
2005 ◽  
Vol 6 (9) ◽  
pp. 891-897 ◽  
Author(s):  
Kristin Michel ◽  
Aidan Budd ◽  
Sofia Pinto ◽  
Toby J Gibson ◽  
Fotis C Kafatos
Keyword(s):  
Anopheles Gambiae ◽  
Plasmodium Berghei ◽  
Malaria Parasite ◽  
Parasite Plasmodium

scholarly journals Inhibitors of Eicosanoid Biosynthesis Reveal that Multiple Lipid Signaling Pathways Influence Malaria Parasite Survival in Anopheles gambiae

Insects ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 307 ◽  
Author(s):  
Kwon ◽  
Smith
Keyword(s):  
Fatty Acids ◽  
Anopheles Gambiae ◽  
Malaria Parasite ◽  
Parasite Infection ◽  
Immune Homeostasis ◽  
Dodecanoic Acid ◽  
Parasite Survival ◽  
Mosquito Anopheles Gambiae ◽  
Inflammatory Drugs ◽  
Specific Inhibitors

Eicosanoids are bioactive signaling lipids derived from the oxidation of fatty acids that act as important regulators of immune homeostasis and inflammation. As a result, effective anti-inflammatory drugs have been widely used to reduce pain and inflammation which target key eicosanoid biosynthesis enzymes. Conserved from vertebrates to insects, the use of these eicosanoid pathway inhibitors offer opportunities to evaluate the roles of eicosanoids in less-characterized insect systems. In this study, we examine the potential roles of eicosanoids on malaria parasite survival in the mosquito Anopheles gambiae. Using Plasmodium oocyst numbers to evaluate parasite infection, general or specific inhibitors of eicosanoid biosynthesis pathways were evaluated. Following the administration of dexamethasone and indomethacin, respective inhibitors of phospholipid A2 (PLA2) and cyclooxygenase (COX), oocyst numbers were unaffected. However, inhibition of lipoxygenase (LOX) activity through the use of esculetin significantly increased oocyst survival. In contrast, 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid (AUDA), an inhibitor of epoxide hydroxylase (EH), decreased oocyst numbers. These experiments were further validated through RNAi experiments to silence candidate genes homologous to EH in An. gambiae to confirm their contributions to Plasmodium development. Similar to the results of AUDA treatment, the silencing of EH significantly reduced oocyst numbers. These results imply that specific eicosanoids in An. gambiae can have either agonist or antagonistic roles on malaria parasite survival in the mosquito host.

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