Diffusion-Weighted MRI Used to Detect in Vivo Modulation of Cortical Spreading Depression: Comparison of Sumatriptan and Tonabersat

2001 ◽  
Vol 172 (2) ◽  
pp. 342-353 ◽  
Author(s):  
Daniel P. Bradley ◽  
Martin I. Smith ◽  
Chaiyapoj Netsiri ◽  
Justin M. Smith ◽  
Kurt H.J. Bockhorst ◽  
...  
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted

scholarly journals Diffusion-weighted MRI of hepatic tumor in rats: Comparison between in vivo and postmortem imaging acquisitions

2009 ◽  
Vol 29 (3) ◽  
pp. 621-628 ◽  
Author(s):  
Xihe Sun ◽  
Huaijun Wang ◽  
Feng Chen ◽  
Frederik De Keyzer ◽  
Jie Yu ◽  
...  
Keyword(s):  
Hepatic Tumor ◽  
Diffusion Weighted Mri ◽  
Postmortem Imaging ◽  
Diffusion Weighted

scholarly journals In Vivo Uptake of [3H]Nimodipine into Brain during Cortical Spreading Depression

1997 ◽  
Vol 17 (5) ◽  
pp. 586-590 ◽  
Author(s):  
Sachiko Osuga ◽  
Antoine M. Hakim ◽  
Hitoshi Osuga ◽  
Matthew J. Hogan
Keyword(s):  
Rat Brain ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Control Group ◽  
Similar Measurement ◽  
Contralateral Hemisphere ◽  
Radiotracer Uptake ◽  
Uptake Studies ◽  
In Vivo Uptake

We report autoradiographic measurements of the in vivo uptake of [3H]nimodipine during the nonischemic depolarization of cortical spreading depression (CSD) in rat brain. [3H]Nimodipine uptake in brain was determined regionally in rats undergoing CSD (n = 8) and was significantly increased in cortex (14 ± 7%) and hippocampus (10 ± 6%) on the stimulated side relative to the contralateral hemisphere when compared with the same measurements in a control group (n = 8). A similar measurement using the physiologically inert radiotracer [14C]iodoantipyrine to control for potential effects of CSD on radioligand distribution showed a minimal increase (2.4 ± 0.7%) of radiotracer uptake in cortex after CSD. This increase was significantly less than that observed in the [3H]nimodipine uptake studies. We hypothesize that increased in vivo [3H]nimodipine uptake in CSD identifies regions of depolarization and thus infers activation of the L-type voltage sensitive calcium channels.

629: The use of diffusion-weighted MRI to study in-vivo fetal lung maturation in a rabbit model

2008 ◽  
Vol 199 (6) ◽  
pp. S181
Author(s):  
Scott Petersen ◽  
Ronald Peeters ◽  
Frederik De Keyzer ◽  
Jan Deprest ◽  
Filip Claus
Keyword(s):  
Rabbit Model ◽  
Fetal Lung ◽  
Diffusion Weighted Mri ◽  
Lung Maturation ◽  
Diffusion Weighted ◽  
Fetal Lung Maturation
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