Do Denervated Peripheral Nerve Trunks Become Ischemic? The Impact of Chronic Denervation on Vasa Nervorum

2001 ◽  
Vol 172 (2) ◽  
pp. 398-406 ◽  
Author(s):  
Ahmet Höke ◽  
Hong S. Sun ◽  
Tessa Gordon ◽  
Douglas W. Zochodne
Keyword(s):  
Peripheral Nerve ◽  
Vasa Nervorum ◽  
Chronic Denervation ◽  
The Impact

scholarly journals The Impact of Aging on Vasa Nervorum, Nerve Blood Flow and Vasopressin Responsiveness

2002 ◽  
Vol 29 (2) ◽  
pp. 164-168 ◽  
Author(s):  
Mikihiro Kihara ◽  
Mitsuaki Shioyama ◽  
Kazuto Okuda ◽  
Mitsuo Takahashi
Keyword(s):  
Blood Flow ◽  
Peripheral Nerve ◽  
Arginine Vasopressin ◽  
Adult Rats ◽  
Nerve Blood Flow ◽  
Vasa Nervorum ◽  
Age Related ◽  
Rat Peripheral Nerve ◽  
Dose Response Study ◽  
The Impact

Abstract:Objective:Aging impacts microvessels in a number of tissue beds. Vasopressin acts as a vasoconstrictor in most blood vessels but may also cause vasodilation. We evaluated the role of aging and vasopressin in the regulation of nerve blood flow (NBF) in rat peripheral nerve.Methods:We undertook a dose-response study to examine the impact of aging on resting NBF and its vasoreactivity to vasopressin. Nerve blood flow was measured using microelectrode hydrogen polarography. Argininevasopressin was administered both intra-arterially and topically.Results:In young adult rats (two months old) topical epineurial application of arginine-vasopressin produced a concentration-dependent reduction of NBF (ED50= 3.8 X 10-5 mol/L). Intra-arterial arginine-vasopressin also reduced NBF. Nerve blood flow was lower in aged rats (12 months old) and less responsive to topically applied vasopressin. The aging group had significantly higher concentrations of vasopressin in plasma than did the younger group.Conclusions:The results suggest that vasopressin constricts vessels in peripheral nerve and that there is an age related decline in the vasoconstrictive response to vasopressin. There may be a reduction in receptor sensitivity in vascular smooth muscle cells in peripheral nerve with increasing age.

Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury

Biomaterials ◽  
2021 ◽  
pp. 121244
Author(s):  
Philip J. Hanwright ◽  
Chenhu Qiu ◽  
Jennifer Rath ◽  
Yang Zhou ◽  
Nicholas von Guionneau ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Chronic Denervation

scholarly journals Combination Preemptive Peripheral Nerve Block in Limb Surgery. A Prospective Study

Medicina ◽  
2020 ◽  
Vol 56 (8) ◽  
pp. 388
Author(s):  
I-Cheng Lu ◽  
Shu-Hung Huang ◽  
David Vi Lu ◽  
Chun Dan Hsu ◽  
Sheng Hua Wu
Keyword(s):  
Pain Management ◽  
Peripheral Nerve ◽  
Nerve Block ◽  
Peripheral Nerve Block ◽  
Recovery Period ◽  
Controlled Study ◽  
Control Group ◽  
Single Shot ◽  
Early Recovery ◽  
The Impact

Background and objectives: Patients often suffer from moderate to severe pain during the early recovery period in orthopedic surgery. We investigated the impact of a single-shot preoperative peripheral nerve block (PNB) on post-anesthesia recovery parameters and interleukin (IL)-6 level during limb surgery. Materials and Methods: A prospective randomized controlled study was conducted, and patients scheduled for limb surgery were recruited. Sixty patients were randomly assigned to either the PNB group or control group, who received morphine as a primary analgesic. The peak verbal numeric rating scale (NRS) score in the post-anesthesia care unit (PACU) was evaluated as a primary outcome. We also recorded rescue analgesics requirement and wake-up time from anesthesia in the PACU. In addition, the change of plasma IL-6 level after incision was measured. Results: Fifty-two patients completed the study, 27 and 25 cases in the PNB and control group, respectively. Preemptive PNB significantly reduced peak NRS score in the PACU compared to control group. Lower rescue analgesics requirement and rapid wake-up from anesthesia were also noted in PNB group. The IL-6 concentration increased less in the PNB group at 2 h after incision. Conclusions: Preemptive PNB attenuates IL-6 expression 2 h after incision and improves pain management in the PACU. PNB was considered as an essential part of pain management in limb surgery.

scholarly journals Functional recovery with peripheral nerve block versus general anesthesia for upper limb surgery: a systematic review protocol

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Jennifer Héroux ◽  
Emilie Belley-Côté ◽  
Pablo Echavé ◽  
Marie-Josée Loignon ◽  
Pierre-Olivier Bessette ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
General Anesthesia ◽  
Nerve Block ◽  
Upper Limb ◽  
Functional Recovery ◽  
Peripheral Nerve Block ◽  
Upper Limb Surgery ◽  
Grade Methodology ◽  
The Impact

Abstract Background Peripheral nerve block is a single injection that inhibits the transmission of peripheral nerve impulses to the central nervous system. The inhibition of the nociceptive impulse may decrease the occurrence of muscle spasm following mobilization postoperatively. This mechanism may contribute to a better functional recovery following upper limb surgery. This systematic review will investigate the impact of peripheral nerve block on functional recovery after an upper limb surgery. Methods We will search studies comparing peripheral nerve block to general anesthesia for upper limb surgery in the following databases: CENTRAL, MEDLINE (Ovid), CINAHL, EMBASE, and Scopus. In duplicate, independent reviewers will assess eligibility, evaluate risk of bias, and abstract data on type of peripheral nerve block and functional outcome. Where possible, we will pool results using a random effects model. For each outcome, we will assess the quality of evidence using GRADE methodology. Discussion We aim to summarize the available evidence comparing functional recovery with peripheral nerve block versus general anesthesia for upper limb surgery. These data will inform the design of a trial on the topic. Systematic review registration PROSPERO CRD42018116298

scholarly journals The Impact of Peripheral Nerve Techniques on Hospital Stay Following Major Orthopedic Surgery

Pain Medicine ◽  
2012 ◽  
Vol 13 (6) ◽  
pp. 828-834 ◽  
Author(s):  
Mark J. Lenart ◽  
Kam Wong ◽  
Rajnish K. Gupta ◽  
Nathaniel D. Mercaldo ◽  
Jonathan S. Schildcrout ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Hospital Stay ◽  
Orthopedic Surgery ◽  
Major Orthopedic Surgery ◽  
The Impact

The impact of reversal of hypoxia by revascularization on the peripheral nerve function of diabetic patients

Diabetologia ◽  
1996 ◽  
Vol 39 (3) ◽  
pp. 344-348
Author(s):  
A. Veves ◽  
V. M. Donaghue ◽  
M. R. Sarnow ◽  
J. M. Giurini ◽  
D. R. Campbell ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Diabetic Patients ◽  
Nerve Function ◽  
Peripheral Nerve Function ◽  
The Impact

scholarly journals The Impact of Low-Dose Insulin on Peripheral Nerve Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e74247 ◽  
Author(s):  
Kazuhiro Sugimoto ◽  
Masayuki Baba ◽  
Susumu Suzuki ◽  
Soroku Yagihashi
Keyword(s):  
Peripheral Nerve ◽  
Insulin Receptor ◽  
Low Dose ◽  
Diabetic Rats ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling ◽  
The Impact

Peripheral nerve block anesthesia/analgesia for patients undergoing primary hip and knee arthroplasty: recommendations from the International Consensus on Anesthesia-Related Outcomes after Surgery (ICAROS) group based on a systematic review and meta-analysis of current literature

2021 ◽  
pp. rapm-2021-102750
Author(s):  
Stavros G Memtsoudis ◽  
Crispiana Cozowicz ◽  
Janis Bekeris ◽  
Dace Bekere ◽  
Jiabin Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Nerve Block ◽  
Knee Arthroplasty ◽  
Peripheral Nerve Block ◽  
Meta Analysis ◽  
Bleeding Complications ◽  
Cochrane Library ◽  
Total Hip ◽  
The Impact

BackgroundEvidence-based international expert consensus regarding the impact of peripheral nerve block (PNB) use in total hip/knee arthroplasty surgery.MethodsA systematic review and meta-analysis: randomized controlled and observational studies investigating the impact of PNB utilization on major complications, including mortality, cardiac, pulmonary, gastrointestinal, renal, thromboembolic, neurologic, infectious, and bleeding complications.Medline, PubMed, Embase, and Cochrane Library including Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, NHS Economic Evaluation Database, were queried from 1946 to August 4, 2020.The Grading of Recommendations Assessment, Development, and Evaluation approach was used to assess evidence quality and for the development of recommendations.ResultsAnalysis of 122 studies revealed that PNB use (compared with no use) was associated with lower ORs for (OR with 95% CIs) for numerous complications (total hip and knee arthroplasties (THA/TKA), respectively): cognitive dysfunction (OR 0.30, 95% CI 0.17 to 0.53/OR 0.52, 95% CI 0.34 to 0.80), respiratory failure (OR 0.36, 95% CI 0.17 to 0.74/OR 0.37, 95% CI 0.18 to 0.75), cardiac complications (OR 0.84, 95% CI 0.76 to 0.93/OR 0.83, 95% CI 0.79 to 0.86), surgical site infections (OR 0.55 95% CI 0.47 to 0.64/OR 0.86 95% CI 0.80 to 0.91), thromboembolism (OR 0.74, 95% CI 0.58 to 0.96/OR 0.90, 95% CI 0.84 to 0.96) and blood transfusion (OR 0.84, 95% CI 0.83 to 0.86/OR 0.91, 95% CI 0.90 to 0.92).ConclusionsBased on the current body of evidence, the consensus group recommends PNB use in THA/TKA for improved outcomes.Recommendation: PNB use is recommended for patients undergoing THA and TKA except when contraindications preclude their use. Furthermore, the alignment of provider skills and practice location resources needs to be ensured. Evidence level: moderate; recommendation: strong.

The impact of peripheral nerve blocks on perioperative outcome in hip and knee arthroplasty—a population-based study

Pain ◽  
2016 ◽  
Vol 157 (10) ◽  
pp. 2341-2349 ◽  
Author(s):  
Stavros G. Memtsoudis ◽  
Jashvant Poeran ◽  
Crispiana Cozowicz ◽  
Nicole Zubizarreta ◽  
Umut Ozbek ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Knee Arthroplasty ◽  
Population Based ◽  
Perioperative Outcome ◽  
Nerve Blocks ◽  
Population Based Study ◽  
Peripheral Nerve Blocks ◽  
Hip And Knee Arthroplasty ◽  
The Impact
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