Induction of Type IV Collagen and Other Basement-Membrane-Associated Proteins after Spinal Cord Injury of the Adult Rat May Participate in Formation of the Glial Scar

2002 ◽  
Vol 173 (1) ◽  
pp. 31-45 ◽  
Author(s):  
Päivi Liesi ◽  
Timo Kauppila
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Basement Membrane ◽  
Type Iv Collagen ◽  
Glial Scar ◽  
Adult Rat ◽  
Type Iv ◽  
Cord Injury ◽  
Associated Proteins

scholarly journals A Collagen-Based Scaffold for Promoting Neural Plasticity in a Rat Model of Spinal Cord Injury

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2245
Author(s):  
Jue-Zong Yeh ◽  
Ding-Han Wang ◽  
Juin-Hong Cherng ◽  
Yi-Wen Wang ◽  
Gang-Yi Fan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Neural Plasticity ◽  
Collagen Scaffold ◽  
Glial Scar ◽  
Beneficial Effects ◽  
Cord Injury

In spinal cord injury (SCI) therapy, glial scarring formed by activated astrocytes is a primary problem that needs to be solved to enhance axonal regeneration. In this study, we developed and used a collagen scaffold for glial scar replacement to create an appropriate environment in an SCI rat model and determined whether neural plasticity can be manipulated using this approach. We used four experimental groups, as follows: SCI-collagen scaffold, SCI control, normal spinal cord-collagen scaffold, and normal control. The collagen scaffold showed excellent in vitro and in vivo biocompatibility. Immunofluorescence staining revealed increased expression of neurofilament and fibronectin and reduced expression of glial fibrillary acidic protein and anti-chondroitin sulfate in the collagen scaffold-treated SCI rats at 1 and 4 weeks post-implantation compared with that in untreated SCI control. This indicates that the collagen scaffold implantation promoted neuronal survival and axonal growth within the injured site and prevented glial scar formation by controlling astrocyte production for their normal functioning. Our study highlights the feasibility of using the collagen scaffold in SCI repair. The collagen scaffold was found to exert beneficial effects on neuronal activity and may help in manipulating synaptic plasticity, implying its great potential for clinical application in SCI.

scholarly journals Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury

2018 ◽  
Vol 35 (15) ◽  
pp. 1745-1754 ◽  
Author(s):  
Nandadevi Patil ◽  
Vincent Truong ◽  
Mackenzie H. Holmberg ◽  
Nicolas S. Lavoie ◽  
Mark R. McCoy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rose Bengal ◽  
Glial Scar ◽  
Chronic Spinal Cord Injury ◽  
Safety And Efficacy ◽  
Cord Injury

Implantation Of Engineered Axon Tracts To Bridge Spinal Cord Injury Beyond The Glial Scar In Rats

2021 ◽  
Author(s):  
Patricia Zadnik Sullivan ◽  
Ahmed Albayar ◽  
Justin C. Burrell ◽  
Kevin Browne ◽  
John Arena ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Scar ◽  
Cord Injury

Separation of the Perivascular Basement Membrane Provides a Conduit for Inflammatory Cells in a Mouse Spinal Cord Injury Model

2010 ◽  
Vol 27 (4) ◽  
pp. 739-751 ◽  
Author(s):  
Tomoyuki Takigawa ◽  
Tomoko Yonezawa ◽  
Teruhito Yoshitaka ◽  
Jun Minaguchi ◽  
Masae Kurosaki ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Basement Membrane ◽  
Inflammatory Cells ◽  
Mouse Spinal Cord ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury
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