Metallothionein-1+2 Protect the CNS after a Focal Brain Injury

2002 ◽  
Vol 173 (1) ◽  
pp. 114-128 ◽  
Author(s):  
Mercedes Giralt ◽  
Milena Penkowa ◽  
Natalia Lago ◽  
Amalia Molinero ◽  
Juan Hidalgo
Keyword(s):  
Brain Injury ◽  
Focal Brain Injury

Localizing focal brain injury via EEG spectral variance

2021 ◽  
Vol 68 ◽  
pp. 102746
Author(s):  
Sina Khanmohammadi ◽  
Osvaldo Laurido-Soto ◽  
Lawrence N. Eisenman ◽  
Terrance T. Kummer ◽  
ShiNung Ching
Keyword(s):  
Brain Injury ◽  
Focal Brain Injury ◽  
Spectral Variance

Visual agnosia and focal brain injury

2017 ◽  
Vol 173 (7-8) ◽  
pp. 451-460 ◽  
Author(s):  
O. Martinaud
Keyword(s):  
Brain Injury ◽  
Visual Agnosia ◽  
Focal Brain Injury

scholarly journals Radiochemical synthesis and evaluation in nonhuman primates of 3-[11C]methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS

2020 ◽  
Author(s):  
Nicolas J. Guehl ◽  
Ramesh Neelamegam ◽  
Yu-Peng Zhou ◽  
Sung-Hyun Moon ◽  
Maeva Dhaynaut ◽  
...  
Keyword(s):  
Brain Injury ◽  
Nonhuman Primates ◽  
Neurological Diseases ◽  
High Plasma ◽  
K Channel ◽  
Pet Tracer ◽  
Highly Sensitive ◽  
Focal Brain Injury ◽  
Pet Radiotracers ◽  
Imaging Properties

Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, it would be valuable to have PET radiotracers that can detect and quantify molecular changes involved in demyelination. Carbon-11 labeled radiotracers present the advantage of allowing for multiple scans on the same subject in the same day. Here, we describe [11C]3MeO4AP, a novel 11C-labeled version of the K+ channel tracer [18F]3F4AP, and characterize its imaging properties in two nonhuman primates including a monkey with a focal brain injury sustained during a surgical procedure three years prior to imaging. Our findings show that [11C]3MeO4AP is brain permeable, metabolically stable and has high plasma availability. When compared with [18F]3F4AP, [11C]3MeO4AP shows very high correlation in volumes of distribution (VT) confirming a common target. [11C]3MeO4AP shows slower washout than [18F]3F4AP suggesting stronger binding. Finally, similar to [18F]3F4AP, [11C]3MeO4AP is highly sensitive to the focal brain injury. All these features make it a promising radioligand for imaging demyelinated lesions.

scholarly journals From first words to grammar in children with focal brain injury

1997 ◽  
Vol 13 (3) ◽  
pp. 275-343 ◽  
Author(s):  
Elizabeth Bates ◽  
Donna Thal ◽  
Doris Trauner ◽  
Judi Fenson ◽  
Dorothy Aram ◽  
...  
Keyword(s):  
Brain Injury ◽  
Focal Brain Injury ◽  
First Words

Plasticity of microglia in remote regions after focal brain injury

2019 ◽  
Vol 94 ◽  
pp. 104-111 ◽  
Author(s):  
Elisa Bisicchia ◽  
Valeria Sasso ◽  
Marco Molinari ◽  
Maria Teresa Viscomi
Keyword(s):  
Brain Injury ◽  
Focal Brain Injury
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