Neuropathology of Mice Carrying Mutant APPswe and/or PS1M146L Transgenes: Alterations in the p75NTR Cholinergic Basal Forebrain Septohippocampal Pathway

2001 ◽  
Vol 170 (2) ◽  
pp. 227-243 ◽  
Author(s):  
Syed Jaffar ◽  
Scott E. Counts ◽  
Shuang Y. Ma ◽  
Elizabeth Dadko ◽  
Marcia N. Gordon ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Cholinergic Basal Forebrain ◽  
Septohippocampal Pathway

Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons

2006 ◽  
Vol 21 (2) ◽  
pp. 413-420 ◽  
Author(s):  
Xiling Ding ◽  
David MacTavish ◽  
Satyabrata Kar ◽  
Jack H. Jhamandas
Keyword(s):  
Basal Forebrain ◽  
Cholinergic Basal Forebrain ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Forebrain Neurons

scholarly journals A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Blaise Robert ◽  
Eyal Y Kimchi ◽  
Yurika Watanabe ◽  
Tatenda Chakoma ◽  
Miao Jing ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Behavioral Outcomes ◽  
Cholinergic Neurons ◽  
Brain Regions ◽  
Brain State ◽  
Cholinergic Basal Forebrain ◽  
Diagonal Band ◽  
Orofacial Movements ◽  
Functional Topography ◽  
Global Brain

Basal forebrain cholinergic neurons (BFCNs) project throughout the cortex to regulate arousal, stimulus salience, plasticity, and learning. Although often treated as a monolithic structure, the basal forebrain features distinct connectivity along its rostrocaudal axis that could impart regional differences in BFCN processing. Here, we performed simultaneous bulk calcium imaging from rostral and caudal BFCNs over a one-month period of variable reinforcement learning in mice. BFCNs in both regions showed equivalently weak responses to unconditioned visual stimuli and anticipated rewards. Rostral BFCNs in the horizontal limb of the diagonal band were more responsive to reward omission, more accurately classified behavioral outcomes, and more closely tracked fluctuations in pupil-indexed global brain state. Caudal tail BFCNs in globus pallidus and substantia innominata were more responsive to unconditioned auditory stimuli, orofacial movements, aversive reinforcement, and showed robust associative plasticity for punishment-predicting cues. These results identify a functional topography that diversifies cholinergic modulatory signals broadcast to downstream brain regions.

Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species

Neuroreport ◽  
2000 ◽  
Vol 11 (10) ◽  
pp. 2177-2183 ◽  
Author(s):  
Liisa A. Tremere ◽  
Raphael Pinaud ◽  
Jens Grosche ◽  
Wolfgang Härtig ◽  
Douglas D. Rasmusson
Keyword(s):  
Basal Forebrain ◽  
Primate Species ◽  
Cholinergic Basal Forebrain

Loss of Developing Cholinergic Basal Forebrain Neurons Following Excitotoxic Lesions of the Hippocampus: Rescue by Neurotrophins

1994 ◽  
Vol 130 (2) ◽  
pp. 178-195 ◽  
Author(s):  
Melanie A. Burke ◽  
William C. Mobley ◽  
Jaeyoung Cho ◽  
Stanley J. Wiegand ◽  
Ronald M. Lindsay ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Cholinergic Basal Forebrain ◽  
Forebrain Neurons
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