Quantification of Functional Recovery Following Rat Sciatic Nerve Transection

2001 ◽  
Vol 168 (1) ◽  
pp. 192-195 ◽  
Author(s):  
Rahul Koka ◽  
Tessa A. Hadlock
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Rat Sciatic Nerve

The long-term functional recovery of repair of sciatic nerve transection with biogenic conduits

Microsurgery ◽  
2012 ◽  
Vol 32 (5) ◽  
pp. 377-382 ◽  
Author(s):  
Vincenzo Penna ◽  
Konstantin Wewetzer ◽  
Beatrix Munder ◽  
G. Bjoern Stark ◽  
Eva M. Lang
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Nerve Transection ◽  
Sciatic Nerve Transection

scholarly journals Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats

2019 ◽  
Author(s):  
Kritika S. Katiyar ◽  
Laura A. Struzyna ◽  
Joseph P. Morand ◽  
Justin C. Burrell ◽  
Basak Clements ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Peripheral Nerves ◽  
Axonal Regeneration ◽  
Axon Regeneration ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Nerve Grafts ◽  
Axonal Regrowth ◽  
Peripheral Axon

AbstractAlthough regeneration of damaged axons in peripheral nerves has long been observed, the mechanisms facilitating this growth are not well characterized. Recently, we demonstrated that host axon regeneration could be greatly enhanced by transplanting engineered living axon tracts to guide outgrowth. Here, we used a model of rat sciatic nerve transection to explore potential mechanisms of this facilitated regeneration and its efficacy in comparison with nerve guidance tubes (NGTs) and autografts. Tissue engineered nerve grafts (TENGs) were developed via “stretch-growth” in mechanobioreactors and consisted of centimeter-scale aligned axonal tracts. Either TENGs, NGTs or autografts (reversed nerve) were then transplanted to bridge a 1 cm segmental gap in the sciatic nerve with the mechanisms of axonal regrowth assessed at 2 weeks and the extent of functional recovery assessed at 16 weeks. We observed numerous host axons growing directly along and intertwining with pre-formed axonal tracts in TENGs. This behavior appears to mimic the action of “pioneer” axons in developmental pathfinding by providing living cues for directed and accelerated outgrowth. Indeed, we found that the rates of axon regeneration were 3-4 fold faster than NGTs and equivalent to autografts. It was also observed that infiltration of host Schwann cells – traditional drivers of peripheral axon regeneration – was both accelerated and progressed directly along TENG axonal tracts. These TENG repairs resulted in levels of functional recovery equivalent to autografts, with each being several fold superior to NGT repairs. This new mechanism – which we term “axon-facilitated axon-regeneration” – may be further exploited to enhance axonal regeneration and functional recovery following neurotrauma.

scholarly journals Administration of CoCl2 Improves Functional Recovery in a Rat Model of Sciatic Nerve Transection Injury

2018 ◽  
Vol 15 (13) ◽  
pp. 1423-1432 ◽  
Author(s):  
Shuai An ◽  
Meng Zhou ◽  
Zheng Li ◽  
Mingli Feng ◽  
Guanglei Cao ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Rat Model ◽  
Nerve Transection ◽  
Sciatic Nerve Transection

scholarly journals Erratum: Corrigendum: Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shih-Tien Hsu ◽  
Chun-Hsu Yao ◽  
Yuan-Man Hsu ◽  
Jia-Horng Lin ◽  
Yung-Hsiang Chen ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Rat Sciatic Nerve

Extracts obtained from predegenerated nerves improve functional recovery after sciatic nerve transection

Microsurgery ◽  
2005 ◽  
Vol 25 (6) ◽  
pp. 486-494 ◽  
Author(s):  
Wieslaw Marcol ◽  
Katarzyna Kotulska ◽  
Magdalena Larysz-Brysz ◽  
Iwona Matuszek ◽  
Edyta Olakowska ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Nerve Transection ◽  
Sciatic Nerve Transection

Early changes of microRNAs expression in the dorsal root ganglia following rat sciatic nerve transection

2011 ◽  
Vol 494 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Songlin Zhou ◽  
Bin Yu ◽  
Tianmei Qian ◽  
Dengbing Yao ◽  
Yongjun Wang ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Rat Sciatic Nerve

scholarly journals Chondroitinase ABC reduces time to muscle reinnervation and improves functional recovery after sciatic nerve transection in rats

2012 ◽  
Vol 107 (3) ◽  
pp. 747-757 ◽  
Author(s):  
Manning J. Sabatier ◽  
Bao Ngoc To ◽  
Samuel Rose ◽  
Jennifer Nicolini ◽  
Arthur W. English
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Time Course ◽  
Emg Activity ◽  
Nerve Transection ◽  
Chondroitinase Abc ◽  
Foot Kinematics ◽  
Sciatic Nerve Transection ◽  
Wide Range ◽  
Treadmill Locomotion

Application of chondroitinase ABC (ChABC) to injured peripheral nerves improves axon regeneration, but it is not known whether functional recovery is also improved. Recordings of EMG activity [soleus (Sol) M response and H reflexes] evoked by nerve stimulation and of Sol and tibialis anterior (TA) EMG activity and hindlimb and foot kinematics during slope walking were made to determine whether ChABC treatment of the sciatic nerve at the time of transection improves functional recovery. Recovery of evoked EMG responses began as multiple small responses with a wide range of latencies that eventually coalesced into one or two more distinctive and consistent responses (the putative M response and the putative H reflex) in both groups. Both the initial evoked responses and the time course of their maturation returned sooner in the ChABC group than in the untreated (UT) group. The reinnervated Sol and TA were coactivated during treadmill locomotion during downslope, level, and upslope walking throughout the study period in both UT and ChABC-treated rats. By 10 wk after nerve transection and repair, locomotor activity in Sol, but not TA, had returned to its pretransection pattern. There was an increased reliance on central control of Sol activation across slopes for both groups as interpreted from elevated prestance Sol EMG activity that was no longer modulated with slope. Limb length and orientation during locomotion were similar to those observed prior to nerve injury during upslope walking only in the ChABC-treated rats. Thus treatment of cut nerves with ChABC leads to improvements in functional recovery.

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