Influence of Time in Culture and BDNF Pretreatment on Survival and Function of Grafted Embryonic Rat Ventral Mesencephalon in the 6-OHDA Rat Model of Parkinson's Disease

2001 ◽  
Vol 167 (1) ◽  
pp. 148-157 ◽  
Author(s):  
G.U. Höglinger ◽  
H.R. Widmer ◽  
C. Spenger ◽  
M. Meyer ◽  
R.W. Seiler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Ventral Mesencephalon ◽  
And Function

Xenotransplantation of Porcine Fetal Ventral Mesencephalon in a Rat Model of Parkinson's Disease: Functional Recovery and Graft Morphology

1996 ◽  
Vol 140 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Wendy R. Galpern ◽  
Lindsay H. Burns ◽  
Terrence W. Deacon ◽  
Jonathan Dinsmore ◽  
Ole Isacson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Recovery ◽  
Rat Model ◽  
Ventral Mesencephalon ◽  
Graft Morphology

Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease

1995 ◽  
Vol 1 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Hldeichi Takayama ◽  
Jasodhara Ray ◽  
Heather K. Raymon ◽  
Andrew Baird ◽  
Joanna Hogg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Graft Survival ◽  
Basic Fibroblast Growth Factor ◽  
Rat Model ◽  
Fibroblast Growth ◽  
And Function

Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease

1989 ◽  
Vol 77 (2) ◽  
pp. 329-336 ◽  
Author(s):  
T. K. Huffaker ◽  
B. D. Boss ◽  
A. S. Morgan ◽  
N. T. Neff ◽  
R. E. Strecker ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Motor Asymmetry ◽  
Ventral Mesencephalon ◽  
Fetal Pig

Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's disease

2003 ◽  
Vol 151 (2) ◽  
pp. 204-217 ◽  
Author(s):  
Richard J. E. Armstrong ◽  
Pamela Tyers ◽  
Meena Jain ◽  
Andrew Richards ◽  
Stephen B. Dunnett ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Ventral Mesencephalon

Survival and Functional Restoration of Human Fetal Ventral Mesencephalon following Transplantation in a Rat Model of Parkinson's Disease

2013 ◽  
Vol 22 (7) ◽  
pp. 1281-1293 ◽  
Author(s):  
Anika Rath ◽  
Alexander Klein ◽  
Anna Papazoglou ◽  
Jan Pruszak ◽  
Joanna Garcia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Functional Restoration ◽  
Ventral Mesencephalon

scholarly journals Simultaneous Transplantation of Fetal Ventral Mesencephalic Tissue and Encapsulated Genetically Modified Cells Releasing GDNF in a Hemi-Parkinsonian Rat Model of Parkinson’s Disease

2017 ◽  
Vol 26 (9) ◽  
pp. 1572-1581 ◽  
Author(s):  
Alberto Perez-Bouza ◽  
Stefano Di Santo ◽  
Stefanie Seiler ◽  
Morten Meyer ◽  
Lukas Andereggen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Genetically Modified ◽  
Graft Function ◽  
Ventral Mesencephalic ◽  
6 Hydroxydopamine ◽  
And Function ◽  
Graft Volume ◽  
Host Brain

Transplantation of fetal ventral mesencephalic (VM) neurons for Parkinson’s disease (PD) is limited by poor survival and suboptimal integration of grafted tissue into the host brain. In a 6-hydroxydopamine rat model of PD, we investigated the feasibility of simultaneous transplantation of rat fetal VM tissue and polymer-encapsulated C2C12 myoblasts genetically modified to produce glial cell line–derived neurotrophic factor (GDNF) or mock-transfected myoblasts on graft function. Amphetamine-induced rotations were assessed prior to transplantation and 2, 4, 6 and 9 wk posttransplantation. We found that rats grafted with VM transplants and GDNF capsules showed a significant functional recovery 4 wk after implantation. In contrast, rats from the VM transplant and mock-capsule group did not improve at any time point analyzed. Moreover, we detected a significantly higher number of tyrosine hydroxylase immunoreactive (TH-ir) cells per graft (2-fold), a tendency for a larger graft volume and an overall higher TH-ir fiber outgrowth into the host brain (1.7-fold) in the group with VM transplants and GDNF capsules as compared to the VM transplant and mock-capsule group. Most prominent was the TH-ir fiber outgrowth toward the capsule (9-fold). Grafting of GDNF-pretreated VM transplants in combination with the implantation of GDNF capsules resulted in a tendency for a higher TH-ir fiber outgrowth into the host brain (1.7-fold) as compared to the group transplanted with untreated VM transplants and GDNF capsules. No differences between groups were observed for the number of surviving TH-ir neurons or graft volume. In conclusion, our findings demonstrate that simultaneous transplantation of fetal VM tissue and encapsulated GDNF-releasing cells is feasible and support the graft survival and function. Pretreatment of donor tissue with GDNF may offer a way to further improve cell transplantation approaches for PD.

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