Time Course and Age Dependence of Motor Neuron Death Following Facial Nerve Crush Injury: Role of Fibroblast Growth Factor

1999 ◽  
Vol 157 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Karl Kuzis ◽  
J.Douglas Coffin ◽  
Felix P. Eckenstein
Keyword(s):  
Growth Factor ◽  
Facial Nerve ◽  
Time Course ◽  
Fibroblast Growth ◽  
Age Dependence ◽  
Neuron Death ◽  
Nerve Crush ◽  
Motor Neuron Death ◽  
Nerve Crush Injury

scholarly journals Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism

2006 ◽  
Vol 154 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Keisuke Kobayashi ◽  
Yasuo Imanishi ◽  
Akimitsu Miyauchi ◽  
Naoyoshi Onoda ◽  
Takehisa Kawata ◽  
...  
Keyword(s):  
Vitamin D ◽  
Growth Factor ◽  
Primary Hyperparathyroidism ◽  
Creatinine Clearance ◽  
Fibroblast Growth Factor ◽  
Time Course ◽  
Parathyroid Glands ◽  
Fibroblast Growth ◽  
Fgf 23

Objective: While the importance of fibroblast growth factor (FGF)-23 is established in phosphate-wasting disorders, little is known about the mechanisms regulating its circulating level. To investigate the role of parathyroid hormone (PTH) and calcium in FGF-23 metabolism, we examined plasma FGF-23 levels in patients with primary hyperparathyroidism (PHPT). Patients and methods: Fifty patients with PHPT and 52 controls were employed in this study. Plasma was obtained from 18 PHPT patients who underwent parathyroidectomy (PTX) on the first postoperative morning without vitamin D administration. Time-course samples were also obtained from 5 of 18 PTX patients without vitamin D analogs or calcium administration. The expression of Fgf23 on resected parathyroid glands was analyzed by reverse transcription (RT)–PCR and immunohistochemistry. Results: FGF-23 was significantly elevated in PHPT patients compared with controls. FGF-23 levels were significantly correlated positively with serum corrected calcium and intact PTH levels, and negatively with creatinine clearance and inorganic phosphate, among which creatinine clearance and corrected calcium were independently associated factors. In 18 PTX patients, postoperative FGF-23 levels were significantly decreased compared with preoperative levels. Corrected-calcium levels were significantly decreased 1 h after PTX, and this was followed by a reduction in plasma FGF-23 levels in time-course study. In addition, postoperative FGF-23 levels in 18 PTX patients were significantly correlated with corrected calcium, consistent with a role of serum calcium as one of the major regulators of FGF-23. The absence of Fgf23 expression in parathyroid glands indicated that the parathyroid glands were not major sources of circulating FGF-23. Conclusions: Serum calcium may regulate circulating FGF-23 levels in PHPT.

scholarly journals The Effect of Insulin Like Growth Factor-1 on Recovery of Facial Nerve Crush Injury

2017 ◽  
Vol 10 (4) ◽  
pp. 296-302 ◽  
Author(s):  
Asuman Feda Bayrak ◽  
Yuksel Olgun ◽  
Ayla Ozbakan ◽  
Safiye Aktas ◽  
Can Ahmet Kulan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Facial Nerve ◽  
Crush Injury ◽  
Insulin Like Growth Factor ◽  
Nerve Crush ◽  
Nerve Crush Injury

The role of fibroblast growth factor-23 in left atrial volume

2013 ◽  
Vol 165 (5) ◽  
pp. e21 ◽  
Author(s):  
Supawat Ratanapo ◽  
Wonngarm Kittanamongkolchai ◽  
Narat Srivali ◽  
Saeed Ahmed ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Left Atrial ◽  
Fibroblast Growth Factor 23 ◽  
Left Atrial Volume ◽  
Fibroblast Growth ◽  
Atrial Volume
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