Specific Invasion of Occipital-to-Frontal Neocortical Grafts by Axons from the Lateral Posterior Thalamic Nucleus Consecutive to Neonatal Lesion of the Rat Occipital Cortex

1998 ◽  
Vol 152 (1) ◽  
pp. 64-73 ◽  
Author(s):  
Jérôme Létang ◽  
Afsaneh Gaillard ◽  
Michel Roger
Keyword(s):  
Thalamic Nucleus ◽  
Occipital Cortex ◽  
Lateral Posterior ◽  
Neonatal Lesion

scholarly journals A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion

2016 ◽  
Vol 11 ◽  
pp. S136-S143
Author(s):  
Chunting He ◽  
Qingfen Chen ◽  
Longkun Zhu
Keyword(s):  
Motor Cortex ◽  
Cryptococcus Neoformans ◽  
Primary Motor Cortex ◽  
Thalamic Nucleus ◽  
Molecular Layer ◽  
Brain Regions ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Novel Approach ◽  
Stratum Lucidum ◽  
Lateral Posterior

Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 ?m) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. 

Cortical connections of the rat lateral posterior thalamic nucleus

2009 ◽  
Vol 1264 ◽  
pp. 39-56 ◽  
Author(s):  
Hiroaki Kamishina ◽  
William L. Conte ◽  
Sarika S. Patel ◽  
Rachel J. Tai ◽  
James V. Corwin ◽  
...  
Keyword(s):  
Thalamic Nucleus ◽  
Cortical Connections ◽  
Lateral Posterior

Striatal projections from the rat lateral posterior thalamic nucleus

2008 ◽  
Vol 1204 ◽  
pp. 24-39 ◽  
Author(s):  
Hiroaki Kamishina ◽  
Geoffrey H. Yurcisin ◽  
James V. Corwin ◽  
Roger L. Reep
Keyword(s):  
Thalamic Nucleus ◽  
Lateral Posterior

Functional Connectivity During Auditory Processing in Huntington’s Disease

2008 ◽  
Vol 22 (4) ◽  
pp. 195-201
Author(s):  
Christian Beste ◽  
Anne Schüttke ◽  
Carsten Konrad ◽  
Carsten Saft ◽  
Jürgen Andrich ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Auditory Processing ◽  
Brain Region ◽  
Thalamic Nucleus ◽  
Region Of Interest ◽  
Occipital Cortex ◽  
Thalamic Nuclei ◽  
Functional Connections

Huntington’s disease (HD) is a neurogenetic disorder accompanied by structural alterations of the basal ganglia. In a recent study we investigated auditory processing in symptomatic and presymptomatic HD. Increased activation intensities were found for the symptomatic-HD group compared to controls, which were assumed to reflect an ability to maintain functioning. However, altered functional connectivities may also give this appearance. In this study we evaluated (1) if functional connections and, hence, the organization between brain areas is also altered and (2) how intensity of activation in a brain region relates to functional connectivities of that brain region. Functional connectivity analysis was applied to the data, including the Heschl gyrus, mediodorsal thalamic nucleus, caudate nucleus, putamen, and, as a control, a region of interest (ROI) in the occipital cortex. The symptomatic group presented higher functional connectivity than the pre-HD and control groups between thalamic nuclei bilaterally, and between the left caudate and left thalamic nucleus, respectively. The pre-HD group showed no altered patterns of functional connectivity compared to controls. Moreover, functional connectivity was inversely related to activation intensity of the corresponding brain region. The results suggest that alterations in functional connectivity in HD possibly relate to the degree of neuropathology and are sensitive to hemisphere-dependent differences in neuropathology. The inverse relation of functional connectivity and activation intensity suggests that they may alternative strategies that can be used to maintain brain function in the neurodegenerative advanced stage in HD patients. Since functional connectivity was not altered until the symptomatic stage, the results indicate that functional connectivity is a robust measure, since it does not alter until late stages of disease, when neuropathology becomes more severe.

Phosphene perceptions and safety of chronic visual cortex stimulation in a blind subject

2020 ◽  
Vol 132 (6) ◽  
pp. 2000-2007 ◽  
Author(s):  
Soroush Niketeghad ◽  
Abirami Muralidharan ◽  
Uday Patel ◽  
Jessy D. Dorn ◽  
Laura Bonelli ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Adverse Events ◽  
Clinical Intervention ◽  
Occipital Cortex ◽  
Neuronal Population ◽  
Serious Adverse Events ◽  
Stimulation Parameters ◽  
The Right ◽  
Visual Cortical ◽  
Stimulation Of

Stimulation of primary visual cortices has the potential to restore some degree of vision to blind individuals. Developing safe and reliable visual cortical prostheses requires assessment of the long-term stability, feasibility, and safety of generating stimulation-evoked perceptions.A NeuroPace responsive neurostimulation system was implanted in a blind individual with an 8-year history of bare light perception, and stimulation-evoked phosphenes were evaluated over 19 months (41 test sessions). Electrical stimulation was delivered via two four-contact subdural electrode strips implanted over the right medial occipital cortex. Current and charge thresholds for eliciting visual perception (phosphenes) were measured, as were the shape, size, location, and intensity of the phosphenes. Adverse events were also assessed.Stimulation of all contacts resulted in phosphene perception. Phosphenes appeared completely or partially in the left hemifield. Stimulation of the electrodes below the calcarine sulcus elicited phosphenes in the superior hemifield and vice versa. Changing the stimulation parameters of frequency, pulse width, and burst duration affected current thresholds for eliciting phosphenes, and increasing the amplitude or frequency of stimulation resulted in brighter perceptions. While stimulation thresholds decreased between an average of 5% and 12% after 19 months, spatial mapping of phosphenes remained consistent over time. Although no serious adverse events were observed, the subject experienced mild headaches and dizziness in three instances, symptoms that did not persist for more than a few hours and for which no clinical intervention was required.Using an off-the-shelf neurostimulator, the authors were able to reliably generate phosphenes in different areas of the visual field over 19 months with no serious adverse events, providing preliminary proof of feasibility and safety to proceed with visual epicortical prosthetic clinical trials. Moreover, they systematically explored the relationship between stimulation parameters and phosphene thresholds and discovered the direct relation of perception thresholds based on primary visual cortex (V1) neuronal population excitation thresholds.

Sign in / Sign up

Export Citation Format

Share Document