Effect of Flupirtine on Bcl-2 and Glutathione Level in Neuronal Cells Treatedin Vitrowith the Prion Protein Fragment (PrP106-126)

1997 ◽  
Vol 147 (2) ◽  
pp. 518-524 ◽  
Author(s):  
Sanja Perovic ◽  
Heinz C. Schröder ◽  
Gabriela Pergande ◽  
Hiroshi Ushijima ◽  
Werner E.G. Müller
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Glutathione Level ◽  
Protein Fragment

scholarly journals Hypoxia protects neuronal cells from human prion protein fragment-induced apoptosis

2010 ◽  
Vol 112 (3) ◽  
pp. 715-722 ◽  
Author(s):  
Jae-Suk Seo ◽  
Jae-Won Seol ◽  
Myung-Hee Moon ◽  
Jae-Kyo Jeong ◽  
You-Jin Lee ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Protein Fragment ◽  
Human Prion Protein ◽  
Induced Apoptosis

STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis

2015 ◽  
Vol 93 ◽  
pp. 191-198 ◽  
Author(s):  
Yaoqian Pan ◽  
Liyong Sun ◽  
Jihong Wang ◽  
Wenzhuo Fu ◽  
Yongyao Fu ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Protein Fragment ◽  
Induced Apoptosis

A Unique Functional Feature of the Recombinant Bovine Prion Protein Fragment

2014 ◽  
Author(s):  
Ying Zhai ◽  
Na Li ◽  
Dachuan Zhang ◽  
Qi Li ◽  
Guoping Zhou ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Fragment ◽  
Functional Feature

scholarly journals Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates

2020 ◽  
Vol 21 (19) ◽  
pp. 7410
Author(s):  
Tomas Sneideris ◽  
Mantas Ziaunys ◽  
Brett K.-Y. Chu ◽  
Rita P.-Y. Chen ◽  
Vytautas Smirnovas
Keyword(s):  
Prion Protein ◽  
Disease Transmission ◽  
Amyloid Fibrils ◽  
The Self ◽  
Transmissible Spongiform Encephalopathies ◽  
Protein Fragment ◽  
Spongiform Encephalopathies ◽  
Amyloid Fibril Formation ◽  
Amyloid Aggregates ◽  
Self Replication

Prion protein amyloid aggregates are associated with infectious neurodegenerative diseases, known as transmissible spongiform encephalopathies. Self-replication of amyloid structures by refolding of native protein molecules is the probable mechanism of disease transmission. Amyloid fibril formation and self-replication can be affected by many different factors, including other amyloid proteins and peptides. Mouse prion protein fragments 107-143 (PrP(107-143)) and 89-230 (PrP(89-230)) can form amyloid fibrils. β-sheet core in PrP(89-230) amyloid fibrils is limited to residues ∼160–220 with unstructured N-terminus. We employed chemical kinetics tools, atomic force microscopy and Fourier-transform infrared spectroscopy, to investigate the effects of mouse prion protein fragment 107-143 fibrils on the aggregation of PrP(89-230). The data suggest that amyloid aggregates of a short prion-derived peptide are not able to seed PrP(89-230) aggregation; however, they accelerate the self-replication of PrP(89-230) amyloid fibrils. We conclude that PrP(107-143) fibrils could facilitate the self-replication of PrP(89-230) amyloid fibrils in several possible ways, and that this process deserves more attention as it may play an important role in amyloid propagation.

scholarly journals Detection of the GPI-anchorless prion protein fragment PrP226* in human brain

BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Eva Dvorakova ◽  
Tanja Vranac ◽  
Olga Janouskova ◽  
Maja Černilec ◽  
Simon Koren ◽  
...  
Keyword(s):  
Human Brain ◽  
Prion Protein ◽  
Protein Fragment

Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment

2005 ◽  
Vol 109 (4) ◽  
pp. 443-448 ◽  
Author(s):  
Sigrun Roeber ◽  
Bjarne Krebs ◽  
Manuela Neumann ◽  
Otto Windl ◽  
Inga Zerr ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Protein Fragment ◽  
Jakob Disease

Haem oxygenase-1 mRNA induction by a prion protein fragment in rat astroglial cells

1995 ◽  
Vol 31 ◽  
pp. 218
Author(s):  
L. Cantoni ◽  
M. Rizzardini ◽  
R. Carcano ◽  
M. Salmona ◽  
R. Chiesa ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Fragment ◽  
Astroglial Cells ◽  
Mrna Induction ◽  
Haem Oxygenase
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