Leukemia Inhibitory Factor Is Expressed in Astrocytes Following Cortical Brain Injury

1997 ◽  
Vol 147 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Lisa R. Banner ◽  
N.Nicole Moayeri ◽  
Paul H. Patterson
Keyword(s):  
Brain Injury ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor

Leukemia Inhibitory Factor Haplodeficiency Desynchronizes Glial Reactivity and Exacerbates Damage and Functional Deficits after a Concussive Brain Injury

2016 ◽  
Vol 33 (16) ◽  
pp. 1522-1534 ◽  
Author(s):  
Matthew T. Goodus ◽  
Nadine A. Kerr ◽  
Ruchika Talwar ◽  
David Buziashvili ◽  
Jennifer E.C. Fragale ◽  
...  
Keyword(s):  
Brain Injury ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Functional Deficits ◽  
Glial Reactivity

scholarly journals Neuroregenerative and protective functions of Leukemia Inhibitory Factor in perinatal hypoxic-ischemic brain injury

2020 ◽  
Vol 330 ◽  
pp. 113324
Author(s):  
Jie Lin ◽  
Yusuke Niimi ◽  
Mariano Guardia Clausi ◽  
Hur Dolunay Kanal ◽  
Steven W. Levison
Keyword(s):  
Brain Injury ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Activation of Cytokine Signaling through Leukemia Inhibitory Factor Receptor (LIFR)/gp130 Attenuates Ischemic Brain Injury in Rats

2005 ◽  
Vol 25 (6) ◽  
pp. 685-693 ◽  
Author(s):  
Shigeaki Suzuki ◽  
Toru Yamashita ◽  
Kortaro Tanaka ◽  
Hidenori Hattori ◽  
Kazunobu Sawamoto ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cerebral Ischemia ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Cytokine Signaling ◽  
Ischemic Damage ◽  
Ischemic Brain Injury ◽  
Leukemia Inhibitory Factor Receptor ◽  
Ischemic Brain ◽  
Phosphorylated Stat3

Cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 is known to exert a neurotrophic action in the central nervous system, although the role of this signaling in cerebral ischemia remains unknown. We examined the effect of intracerebral injection of LIF after focal cerebral ischemia in rats. The animals underwent a sham operation (sham group) or middle cerebral artery occlusion (MCAO) followed by direct injection of either vehicle (phosphate-buffered saline, the PBS group) or recombinant LIF (10 ng in the low-LIF group and 100 ng in the high-LIF group) into the cerebral cortex adjacent to the inner boundary zone of the infarct area, and neurologic and histologic evaluations were conducted 24 h later. Expression of LIFR, gp130, and phosphorylated Stat3, Akt, and ERK1/2 was investigated by Western blot analysis and immunohistochemistry. The neurologic deficits and ischemic damage were significantly less severe in the high-LIF group than in the PBS group and the low-LIF group. Leukemia inhibitory factor receptor and gp130 were expressed in neurons, and the ischemic damage of these proteins was rescued in the high-LIF group. Early induction of phosphorylated Stat3 was significantly detected on the ischemic side in the high-LIF group after LIF injection. Exogenous LIF attenuates ischemic brain injury by activating cytokine signaling through LIFR/gp130.

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