Dexamethasone Enhances Mallory Body Formation in Drug-Primed Mouse Liver

2000 ◽  
Vol 69 (3) ◽  
pp. 202-210 ◽  
Author(s):  
Qi X. Yuan ◽  
Yasuyuki Nagao ◽  
Barbara A. French ◽  
Yu-Jui Yvonne Wan ◽  
Samuel W. French
Keyword(s):  
Mouse Liver ◽  
Body Formation ◽  
Primed Mouse

Heat Shock in Vivo Induces Mallory Body Formation in Drug Primed Mouse Liver

1995 ◽  
Vol 63 (1) ◽  
pp. 63-76 ◽  
Author(s):  
Qi X. Yuan ◽  
Normand Marceau ◽  
Barbara A. French ◽  
Paul Fu ◽  
Samuel W. French
Keyword(s):  
Heat Shock ◽  
Mouse Liver ◽  
Body Formation ◽  
Primed Mouse

scholarly journals Bile Acid-Induced Mallory Body Formation in Drug-Primed Mouse Liver

2002 ◽  
Vol 161 (6) ◽  
pp. 2019-2026 ◽  
Author(s):  
Peter Fickert ◽  
Michael Trauner ◽  
Andrea Fuchsbichler ◽  
Conny Stumptner ◽  
Kurt Zatloukal ◽  
...  
Keyword(s):  
Bile Acid ◽  
Mouse Liver ◽  
Body Formation ◽  
Primed Mouse

scholarly journals The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury

Hepatology ◽  
2008 ◽  
Vol 48 (3) ◽  
pp. 943-952 ◽  
Author(s):  
Shinichiro Hanada ◽  
Pavel Strnad ◽  
Elizabeth M. Brunt ◽  
M. Bishr Omary
Keyword(s):  
Liver Injury ◽  
Genetic Background ◽  
Mouse Liver ◽  
Body Formation

scholarly journals Aging Modulates Susceptibility to Mouse Liver Mallory-Denk Body Formation

2012 ◽  
Vol 60 (6) ◽  
pp. 475-483 ◽  
Author(s):  
Shinichiro Hanada ◽  
Masaru Harada ◽  
Mitsuhiko Abe ◽  
Jun Akiba ◽  
Masahiro Sakata ◽  
...  
Keyword(s):  
Mouse Liver ◽  
Body Formation

Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation

2001 ◽  
Vol 34 (5) ◽  
pp. 665-675 ◽  
Author(s):  
Cornelia Stumptner ◽  
Andrea Fuchsbichler ◽  
Manfred Lehner ◽  
Kurt Zatloukal ◽  
Helmut Denk
Keyword(s):  
Mouse Liver ◽  
Body Formation ◽  
Sequence Of Events ◽  
Body Components

Mallory body induction in drug-primed mouse liver

Hepatology ◽  
1996 ◽  
Vol 24 (3) ◽  
pp. 603-612 ◽  
Author(s):  
Q X Yuan ◽  
N Marceau ◽  
B A French ◽  
P Fu ◽  
S W French
Keyword(s):  
Mouse Liver ◽  
Primed Mouse

Ultrastructural localization of specific nucleoprotein fractions

1978 ◽  
Vol 36 (2) ◽  
pp. 204-205
Author(s):  
G. L. Brown
Keyword(s):  
Gel Electrophoresis ◽  
Mouse Liver ◽  
Polyacrylamide Gel Electrophoresis ◽  
Ultrastructural Localization ◽  
Polyacrylamide Gel ◽  
Acid Extraction ◽  
Acid Solutions ◽  
Low Salt ◽  
Liver Nuclei ◽  
Phosphate Groups

Bismuth (Bi) stains nucleoproteins (NPs) by interacting with available amino and primary phosphate groups. These two staining mechanisms are distinguishable by glutaraldehyde crosslinking (Fig. 1,2).Isolated mouse liver nuclei, extracted with salt and acid solutions, fixed in either formaldehyde (form.) or gl utaraldehyde (glut.) and stained with Bi, were viewed to determine the effect of the extractions on Bi stainina. Solubilized NPs were analyzed by SDS-polyacrylamide gel electrophoresis.Extraction with 0.14 M salt does not change the Bi staining characteristics (Fig. 3). 0.34 M salt reduces nucleolar (Nu) staining but has no effect on interchromatinic (IC) staining (Fig. 4). Proteins responsible for Nu and glut.- insensitive IC staining are removed when nuclei are extracted with 0.6 M salt (Fig. 5, 6). Low salt and acid extraction prevents Bi-Nu staining but has no effect on IC staining (Fig. 7). When nuclei are extracted with 0.6 M salt followed by low salt and acid, all Bi-staining components are removed (Fig. 8).

Site of Lysosome Production During Hepatic Injury

1969 ◽  
Vol 27 ◽  
pp. 348-349
Author(s):  
Nalin J. Unakar
Keyword(s):  
Electron Microscopy ◽  
Golgi Apparatus ◽  
Mouse Liver ◽  
Hepatic Injury ◽  
Close Approximation ◽  
Experimental Conditions ◽  
Toxic Injury

The increased number of lysosomes as well as the close approximation of lysosomes to the Golgi apparatus in tissue under variety of experimental conditions is commonly observed. These observations suggest Golgi involvement in lysosomal production. The role of the Golgi apparatus in the production of lysosomes in mouse liver was studied by electron microscopy of liver following toxic injury by CCI4.

Nuclear coiled bodies and the nucleolus

1994 ◽  
Vol 52 ◽  
pp. 20-21
Author(s):  
K. Brasch ◽  
J. Williams ◽  
D. Gallo ◽  
T. Lee ◽  
R. L. Ochs
Keyword(s):  
Mouse Liver ◽  
Nuclear Body ◽  
Nuclear Bodies ◽  
Model Systems ◽  
Coiled Body ◽  
Rrna Processing ◽  
Malignant Cells ◽  
Sm Proteins ◽  
Coiled Bodies ◽  
Unique Protein

Though first described in 1903 by Ramon-y-Cajal as silver-staining “accessory bodies” to nucleoli, nuclear bodies were subsequently rediscovered by electron microscopy about 30 years ago. Nuclear bodies are ubiquitous, but seem most abundant in hyperactive and malignant cells. The best studied type of nuclear body is the coiled body (CB), so termed due to characteristic morphology and content of a unique protein, p80-coilin (Fig.1). While no specific functions have as yet been assigned to CBs, they contain spliceosome snRNAs and proteins, and also the nucleolar protein fibrillarin. In addition, there is mounting evidence that CBs arise from or are generated near the nucleolus and then migrate into the nucleoplasm. This suggests that as yet undefined links may exist, between nucleolar pre-rRNA processing events and the spliceosome-associated Sm proteins in CBs.We are examining CB and nucleolar changes in three diverse model systems: (1) estrogen stimulated chick liver, (2) normal and neoplastic cells, and (3) polyploid mouse liver.

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