The Role of Laminin-5 in TGFα/EGF-Mediated Corneal Epithelial Cell Motility

1998 ◽  
Vol 66 (5) ◽  
pp. 569-579 ◽  
Author(s):  
PING QIN ◽  
MICHELLE A. KURPAKUS
Keyword(s):  
Epithelial Cell ◽  
Cell Motility ◽  
Corneal Epithelial Cell ◽  
Laminin 5 ◽  
Corneal Epithelial

scholarly journals Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kyu-Yeon Han ◽  
Jennifer A. Tran ◽  
Jin-Hong Chang ◽  
Dimitri T. Azar ◽  
James D. Zieske
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Potential Role ◽  
Corneal Epithelial Cell ◽  
Corneal Wound Healing ◽  
Corneal Epithelial ◽  
Corneal Wound

Recurrent corneal erosion syndrome

2019 ◽  
Vol 103 (9) ◽  
pp. 1204-1208 ◽  
Author(s):  
Shawn Rong Lin ◽  
Anthony J Aldave ◽  
James Chodosh
Keyword(s):  
Epithelial Cell ◽  
Cell Biology ◽  
Treatment Modalities ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Corneal Erosion ◽  
Epithelial Basement Membrane ◽  
Recurrent Corneal Erosion ◽  
Epithelial Basement

Recurrent corneal erosion syndrome (RCES) is a disorder characterised by a dysfunctional epithelial ecosystem. It often begins after trauma, or in the setting of epithelial basement membrane degeneration or dystrophy. Historically, RCES has been understood as a structural derangement of the anterior corneal architecture. More recently, studies have demonstrated the important role of neuropeptides in corneal homoeostasis. Thus, RCES may also be understood as a disorder of corneal epithelial cell biology. Management of RCES can be challenging, but newer therapies have demonstrated improved efficacy for this condition. This review examines the aetiology and pathogenesis of RCES, and provides an update on current and emerging treatment modalities for the management of this disorder.

Paracrine Role of Keratinocyte Growth Factor in Rabbit Corneal Epithelial Cell Growth

1994 ◽  
Vol 59 (4) ◽  
pp. 385-392 ◽  
Author(s):  
Chie Sotozono ◽  
Shigeru Kinoshita ◽  
Masakazu Kita ◽  
Jiro Imanishi
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Epithelial Cell ◽  
Keratinocyte Growth Factor ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial

Role of β-Pix in Corneal Epithelial Cell Migration on Fibronectin

2011 ◽  
Vol 52 (6) ◽  
pp. 3181 ◽  
Author(s):  
Kazuhiro Kimura ◽  
Shinichiro Teranishi ◽  
Tomoko Orita ◽  
Hongyan Zhou ◽  
Teruo Nishida
Keyword(s):  
Cell Migration ◽  
Epithelial Cell ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Epithelial Cell Migration

scholarly journals Role of the LewisxGlycan Determinant in Corneal Epithelial Cell Adhesion and Differentiation

2001 ◽  
Vol 276 (24) ◽  
pp. 21714-21723 ◽  
Author(s):  
Zhiyi Cao ◽  
Zheng Zhao ◽  
Royce Mohan ◽  
Joseph Alroy ◽  
Pamela Stanley ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial

Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells

2001 ◽  
Vol 114 (22) ◽  
pp. 4033-4040
Author(s):  
Miechia A. Esco ◽  
Zhiyu Wang ◽  
Mark L. McDermott ◽  
Michelle Kurpakus-Wheater
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Mitochondrial Membrane ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial Cells ◽  
Laminin 5 ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells ◽  
Cells Cultured

Laminin 5 functions to promote cell-matrix adhesion and therefore is hypothesized to abrogate apoptosis initiated through the loss of epithelial cell contact with extracellular matrix. Laminin 5 levels are decreased in epithelial cells cultured in a hypoxic environment. Exposure of epithelial cells to hypoxia may induce apoptotic pathways transmitted through changes in mitochondrial membrane potential. Using an apoptosis assay based on mitochondrial membrane integrity, the effect of hypoxia (2% oxygen) on human corneal epithelial cell viability was determined. Both a virally transformed corneal epithelial cell line and third passage corneal epithelial cells were resistant to hypoxia-mediated apoptosis for up to 5 days in culture. However, at 7 days in culture, a statistically significant increase in apoptosis was noted in hypoxic corneal epithelial cells compared to normoxic (20% oxygen) controls. Increased apoptosis in hypoxic epithelium at 7 days in culture correlated with decreased deposition of laminin 5 into the extracellular matrix, as determined by western blot analysis and immunofluorescence microscopy. Additionally, the extracellular processing of the α3 and γ2 chains of laminin 5 was negatively impacted by corneal epithelial cell exposure to hypoxia for 7 days. Treatment of human corneal epithelial cells cultured in 20% oxygen with function-inhibiting antibodies to laminin 5 for 2 or 3 days resulted in a statistically significant decrease in proliferation, and concomitant increase in apoptosis, compared with untreated normoxic controls. Based on these results, it appears that mechanisms of hypoxia-mediated apoptosis in human corneal epithelial cells may be initiated by the loss of processed laminin 5 in the extracellular matrix or by the loss of laminin 5-epithelial cell communication and transmitted through mitochondria.

scholarly journals Silk Film Stiffness Modulates Corneal Epithelial Cell Mechanosignaling

2021 ◽  
Vol 222 (7) ◽  
pp. 2170013
Author(s):  
Michael G. Sun ◽  
Yuncin Luo ◽  
Tao Teng ◽  
Victor Guaiquil ◽  
Qiang Zhou ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Film Stiffness ◽  
Silk Film

Effects of matrix proteins on rabbit corneal epithelial cell adhesion and migration

1988 ◽  
Vol 7 (3) ◽  
pp. 293-301 ◽  
Author(s):  
J. D. Cameron ◽  
S. T. Hagen ◽  
R. R. Waterfield ◽  
L. T. Furcht
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Matrix Proteins ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Cell Adhesion And Migration ◽  
And Migration
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