Identification of Endothelin Receptor Subtypes in Rat Ciliary Body Using Subtype-Selective Ligands

1998 ◽  
Vol 66 (1) ◽  
pp. 69-79 ◽  
Author(s):  
AINHOA RIPODAS ◽  
JOSE A. DE JUAN ◽  
F.JOSE MOYA ◽  
ARTURO FERNANDEZ-CRUZ ◽  
RAQUEL FERNANDEZ-DURANGO
Keyword(s):  
Ciliary Body ◽  
Receptor Subtypes ◽  
Endothelin Receptor ◽  
Selective Ligands ◽  
Subtype Selective

Identification of endothelin receptor subtypes in rat retina using subtype-selective ligands

1995 ◽  
Vol 690 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Jose Angel de Juan ◽  
Francisco Jose Moya ◽  
Arturo Fernandez-Cruz ◽  
Raquel Fernandez-Durango
Keyword(s):  
Receptor Subtypes ◽  
Endothelin Receptor ◽  
Rat Retina ◽  
Selective Ligands ◽  
Subtype Selective

Identification of endothelin receptor subtypes in human renal cortex and medulla using subtype-selective ligands.

Endocrinology ◽  
1992 ◽  
Vol 131 (3) ◽  
pp. 1081-1086 ◽  
Author(s):  
P Nambi ◽  
M Pullen ◽  
H L Wu ◽  
N Aiyar ◽  
E H Ohlstein ◽  
...  
Keyword(s):  
Renal Cortex ◽  
Receptor Subtypes ◽  
Endothelin Receptor ◽  
Selective Ligands ◽  
Subtype Selective

Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1

1992 ◽  
Vol 182 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Kyoko Nakamichi ◽  
Masaki Ihara ◽  
Masahiko Kobayashi ◽  
Toshihiko Saeki ◽  
Kiyofumi Ishikawa ◽  
...  
Keyword(s):  
Receptor Subtypes ◽  
The Novel ◽  
Endothelin Receptor ◽  
Selective Ligands

Identification of Endothelin Receptor Subtype (ETB) in Human Cerebral Cortex Using Subtype-Selective Ligands

2008 ◽  
Vol 62 (4) ◽  
pp. 1482-1488 ◽  
Author(s):  
Raquel Fernández-Durango ◽  
José A. Juan ◽  
Horatio Zimman ◽  
Francisco J. Moya ◽  
Mario Garcia de la Coba ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Receptor Subtype ◽  
Endothelin Receptor ◽  
Human Cerebral Cortex ◽  
Selective Ligands ◽  
Subtype Selective

Receptor subtypes for natriuretic peptides in the brains of hypertensive rats

1991 ◽  
Vol 260 (2) ◽  
pp. R441-R447 ◽  
Author(s):  
J. Brown ◽  
A. Czarnecki
Keyword(s):  
Radioligand Binding ◽  
Receptor Subtypes ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Kd Values ◽  
Selective Ligands ◽  
Clearance Receptor ◽  
Wistar Kyoto ◽  
Subtype Selective

Receptor subtypes for alpha-atrial natriuretic peptide (alpha-ANP) were characterized in brains of 12-wk-old Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) by in vitro autoradiography, using des[Gln18, Ser19,Gly20,Leu21,Gly22]ANP-(4-23) (C-ANP) and ANP-(5-25) as subtype-selective ligands. 125I-labeled alpha-ANP (200 pM) bound reversibly to arachnoid mater (AM), choroid plexus (ChP), subfornical organ (SFO), median preoptic nucleus, and supraoptic nucleus. Apparent Kd values for alpha-ANP in AM, ChP, and SFO were 1-6 nM and they were lowest in SHR. Maximal binding capacities for alpha-ANP on ChP and SFO were also significantly lower in SHR, and 10 microM C-ANP or 10 microM ANP-(5-25) inhibited most radioligand binding on AM of WKY and SHR. C-ANP significantly inhibited no other alpha-125I-ANP binding. ANP-(5-25) was a relatively weak inhibitor of alpha-125I-ANP binding to ChP and SFO in WKY but it was powerful in SHR. The results suggest that AM expresses clearance receptor for alpha-ANP in WKY and SHR. Other structures do not express this receptor significantly but express two other receptors for alpha-ANP, one mainly in WKY and one mainly in SHR.

Significance of Endothelin Receptor Subtypes in the Kidneys of Spontaneously Hypertensive Rats

1995 ◽  
Vol 26 ◽  
pp. S470-472
Author(s):  
Berthold Hocher ◽  
Peter Rohmeiss ◽  
Rüdiger Zart ◽  
Fritz Diekmann ◽  
Volker Vogt ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Receptor Subtypes ◽  
Endothelin Receptor ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Localization and Distribution of Endothelin Receptor Subtypes in Pulmonary Vasculature of Normal and Hypoxia-Exposed Rats

1999 ◽  
Vol 20 (4) ◽  
pp. 620-630 ◽  
Author(s):  
Sanae Soma ◽  
Hideki Takahashi ◽  
Masashi Muramatsu ◽  
Masahiko Oka ◽  
Yoshinosuke Fukuchi
Keyword(s):  
Pulmonary Vasculature ◽  
Receptor Subtypes ◽  
Endothelin Receptor

Serotonin Receptor Subtypes: Implications for Psychopharmacology

1991 ◽  
Vol 159 (S12) ◽  
pp. 7-14 ◽  
Author(s):  
P. J. Cowen
Keyword(s):  
Cognitive Processes ◽  
Serotonin Receptor ◽  
Antidepressant Treatment ◽  
Receptor Subtypes ◽  
Therapeutic Effects ◽  
Controlled Clinical Trials ◽  
Wide Range ◽  
Selective Ligands ◽  
Coupling Mechanisms ◽  
Therapeutic Possibilities

Serotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. Nevertheless, manipulation of several different 5-HT receptor subtypes (5-HT1A, 5-HT1c, 5-HT2 and 5-HT3) may produce anxiolytic effects; 5-HT1A and 5-HT2 receptors may be involved in the aetiology of major depression and the therapeutic effects of antidepressant treatment; and 5-HT3 receptors have been linked to reward mechanisms and cognitive processes. These advances offer therapeutic possibilities, the value of which can only be satisfactorily assessed by controlled clinical trials.

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