gp130 Activation by Soluble Interleukin-6 Receptor/Interleukin-6 Enhances Osteoblastic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

2002 ◽  
Vol 280 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Alejandro Erices ◽  
Paulette Conget ◽  
Cecilia Rojas ◽  
José J. Minguell
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Interleukin 6 ◽  
Osteoblastic Differentiation ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Interleukin 6 Receptor

scholarly journals Xenogenic bone matrix extracts induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

2007 ◽  
Vol 2 (4) ◽  
pp. 383-390 ◽  
Author(s):  
Marwan E El-Sabban ◽  
Hilda El-Khoury ◽  
Rima Hamdan-Khalil ◽  
Steen Sindet-Pedersen ◽  
Ali Bazarbachi
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Bone Matrix ◽  
Osteoblastic Differentiation ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Xenogenic Bone

scholarly journals Circ_0067680 expedites the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through miR-4429/CTNNB1/Wnt/β-catenin pathway

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yuansheng Huang ◽  
Su Wan ◽  
Min Yang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Regulatory Mechanism ◽  
Osteoblastic Differentiation ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Luciferase Reporter

Abstract Background Human bone marrow-derived mesenchymal stem cells (hBMSCs) are the primary source of osteoblasts in vivo. Emerging literatures have unveiled that circular RNAs (circRNAs) are actively drawn in the osteogenic differentiation of mesenchymal stem cells (MSCs). This research mainly illuminated the role of circ_0067680 as well as its regulatory mechanism in osteoblastic differentiation. Methods In this study, RT-qPCR was to measure the expression of circ_0067680. Functional assays were implemented to assess the role of circ_0067680 in osteogenic differentiation. Besides, RNA pull down, RIP and luciferase reporter assays were carried out to investigate the regulatory mechanism of circ_0067680. Results Circ_0067680, which derived from its host gene divergent protein kinase domain 2A (C3orf58), was up-regulated during osteogenic differentiation of hBMSCs. Besides, circ_0067680 deficiency impeded the osteoblastic differentiation of hBMSCs. Moreover, circ_0067680 served as a ceRNA via sequestering miR-4429 to regulate the expression of catenin beta 1 (CTNNB1), thereby activating the Wnt/β-catenin signaling pathway. Conclusion Circ_0067680 accelerated hBMSCs osteogenic differentiation by the miR-4429/CTNNB1/Wnt/β-catenin signaling, which might be used as a potential biomarker for osteoblastic differentiation. Graphic abstract

Candidate kinases for adipogenesis and osteoblastogenesis from human bone marrow mesenchymal stem cells

2021 ◽  
Author(s):  
Xia Yi ◽  
Ping Wu ◽  
Jianyun Liu ◽  
Shan He ◽  
Ying Gong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Transcription Factors ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cytoplasmic Proteins ◽  
Marrow Mesenchymal Stem Cells

Adipogenesis and osteoblastogenesis (adipo-osteoblastogenesis) are closely related processes involving with the phosphorylation of numerous cytoplasmic proteins and key transcription factors.

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