The Effector Phase of Physiological Cell Death Relies Exclusively on the Posttranslational Activation of Resident Components

2002 ◽  
Vol 277 (1) ◽  
pp. 15-30 ◽  
Author(s):  
Sandra H. Chang ◽  
Marija Cvetanovic ◽  
Kevin J. Harvey ◽  
Akira Komoriya ◽  
Beverly Z. Packard ◽  
...  
Keyword(s):  
Cell Death ◽  
Effector Phase ◽  
Physiological Cell Death

Protein Synthesis during Programmed (Physiological) Cell Death

1991 ◽  
pp. 451-459
Author(s):  
R. A. Lockshin ◽  
Z. F. Zakeri ◽  
L. M. Yesner
Keyword(s):  
Cell Death ◽  
Protein Synthesis ◽  
Physiological Cell Death

scholarly journals Cathepsin D gene expression outlines the areas of physiological cell death during embryonic development

2007 ◽  
Vol 236 (3) ◽  
pp. 880-885 ◽  
Author(s):  
V. Zuzarte-Luis ◽  
J.A. Montero ◽  
N. Torre-Perez ◽  
J.A. Garcia-Porrero ◽  
J.M. Hurle
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Embryonic Development ◽  
Cathepsin D ◽  
Physiological Cell Death

Cell-Adhesion to Crystal Surfaces: Adhesion-Induced Physiological Cell Death

1996 ◽  
Vol 4 (4-5) ◽  
pp. 341-353 ◽  
Author(s):  
Dorit Hanein ◽  
Anat Yarden ◽  
Helena Sabanay ◽  
Lia Addadi ◽  
Benjamin Geiger
Keyword(s):  
Cell Death ◽  
Cell Adhesion ◽  
Crystal Surfaces ◽  
Physiological Cell Death

The medical significance of physiological cell death

1995 ◽  
Vol 15 (4) ◽  
pp. 299-311 ◽  
Author(s):  
Georg Häucker ◽  
David L. Vaux
Keyword(s):  
Cell Death ◽  
Physiological Cell Death

The Role of the Pro-Apoptotic Bcl-2 Family Member Bim in Physiological Cell Death

2006 ◽  
Vol 926 (1) ◽  
pp. 83-89 ◽  
Author(s):  
PHILIPPE BOUILLET ◽  
DAVID C.S. HUANG ◽  
LORRAINE A. O'REILLY ◽  
HAMSA PUTHALAKATH ◽  
LIAM O'CONNOR ◽  
...  
Keyword(s):  
Cell Death ◽  
Family Member ◽  
Physiological Cell Death

scholarly journals Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 ◽  
Vol 12 (7) ◽  
pp. 3060-3069 ◽  
Author(s):  
D S Ucker ◽  
P S Obermiller ◽  
W Eckhart ◽  
J R Apgar ◽  
N A Berger ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytotoxic T Lymphocyte ◽  
Death Process ◽  
Cell Nuclei ◽  
Calcium Dependent ◽  
Nuclear Envelope Breakdown ◽  
Murine Fibroblast ◽  
Cell Death Process ◽  
Cell Suicide ◽  
Physiological Cell Death

We examined virally transformed murine fibroblast clones as targets for cytotoxic T lymphocyte (CTL)-triggered lysis and genome digestion. Strikingly, while all clones were essentially equivalent in the ability to be lysed, one clone, SV3T3-B2.1, failed to exhibit genome digestion associated with CTL attack. Other aspects of the physiological cell death process, including loss of adhesion and nuclear envelope breakdown (lamin phosphorylation and solubilization), were not altered in this clone. The absence of genome digestion associated with CTL-induced cell death correlated with the absence of endodeoxyribonuclease activity in the nuclei of that clone. Characterization of the activity affected identifies a calcium-dependent, DNase I-like endonuclease of approximately 40 kDa, normally present constitutively in all cell nuclei, as the enzyme responsible for genome digestion associated with CTL-mediated cell death. These observations indicate that neither genome digestion per se nor its consequences [such as activation of poly(ADP-ribose) polymerase] are essential for cell death resulting from the triggering of this cell suicide process.

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes

1992 ◽  
Vol 12 (7) ◽  
pp. 3060-3069
Author(s):  
D S Ucker ◽  
P S Obermiller ◽  
W Eckhart ◽  
J R Apgar ◽  
N A Berger ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytotoxic T Lymphocyte ◽  
Death Process ◽  
Cell Nuclei ◽  
Calcium Dependent ◽  
Nuclear Envelope Breakdown ◽  
Murine Fibroblast ◽  
Cell Death Process ◽  
Cell Suicide ◽  
Physiological Cell Death

We examined virally transformed murine fibroblast clones as targets for cytotoxic T lymphocyte (CTL)-triggered lysis and genome digestion. Strikingly, while all clones were essentially equivalent in the ability to be lysed, one clone, SV3T3-B2.1, failed to exhibit genome digestion associated with CTL attack. Other aspects of the physiological cell death process, including loss of adhesion and nuclear envelope breakdown (lamin phosphorylation and solubilization), were not altered in this clone. The absence of genome digestion associated with CTL-induced cell death correlated with the absence of endodeoxyribonuclease activity in the nuclei of that clone. Characterization of the activity affected identifies a calcium-dependent, DNase I-like endonuclease of approximately 40 kDa, normally present constitutively in all cell nuclei, as the enzyme responsible for genome digestion associated with CTL-mediated cell death. These observations indicate that neither genome digestion per se nor its consequences [such as activation of poly(ADP-ribose) polymerase] are essential for cell death resulting from the triggering of this cell suicide process.

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