Stimulation of Oxygen Consumption Promotes Mitochondrial Calcium Accumulation, a Process Associated with, and Causally Linked to, Enhanced Formation oftert-Butylhydroperoxide-Induced DNA Single-Strand Breaks☆

1997 ◽  
Vol 237 (1) ◽  
pp. 176-185 ◽  
Author(s):  
A GUIDARELLI ◽  
L BRAMBILLA ◽  
E CLEMENTI ◽  
C SCIORATI ◽  
O CANTONI
Keyword(s):  
Oxygen Consumption ◽  
Single Strand ◽  
Mitochondrial Calcium ◽  
Strand Breaks ◽  
Calcium Accumulation ◽  
Single Strand Breaks ◽  
Stimulation Of

Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage

1990 ◽  
Vol 68 (3) ◽  
pp. 602-608 ◽  
Author(s):  
Dominique Lautier ◽  
Danièle Poirier ◽  
Annie Boudreau ◽  
Moulay A. Alaoui Jamali ◽  
André Castonguay ◽  
...  
Keyword(s):  
Free Radicals ◽  
Active Oxygen Species ◽  
Accurate Determination ◽  
Active Oxygen ◽  
Single Strand ◽  
Oxygen Species ◽  
Strand Breaks ◽  
Dna Breakage ◽  
Single Strand Breaks ◽  
Stimulation Of

We have studied the effect of H2O2 and O2− produced by xanthine and xanthine oxidase on NAD catabolism, poly(ADP-ribose) synthesis, and production of DNA single-strand breaks in C3H10T1/2 cells. The results show a correlation between the induction of DNA single-strand breaks, the decrease of NAD pool, and the accumulation of polymer. New techniques, based on affinity chromatography and reversed-phase high pressure liquid chromatography, have allowed an accurate determination of polymer contents and showed a 20-fold stimulation of polymer biosynthesis induced by active oxygen species. Inhibition experiments performed with 3-aminobenzamide have shown that the decrease in NAD levels after exposure of cells to active oxygen species was caused by stimulation of poly(ADP-ribosyl)ation and of another cellular process.Key words: poly(ADP-ribose), free radicals, C3H10T1/2 cells, DNA breakage, NAD catabolism.

The stimulation of DNA-PK by radiation-induced complex single strand breaks

2001 ◽  
Vol 29 (1) ◽  
pp. A31-A31
Author(s):  
P. Palmer ◽  
C. J. Skidmore ◽  
P. O'Neill-
Keyword(s):  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Radiation Induced ◽  
Stimulation Of

Mechanism of chromosome rearrangement arising from single-strand breaks

2021 ◽  
Author(s):  
Palina Kot ◽  
Takaaki Yasuhara ◽  
Atsushi Shibata ◽  
Miyako Hirakawa ◽  
Yu Abe ◽  
...  
Keyword(s):  
Chromosome Rearrangement ◽  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks
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