scholarly journals BMP Pathways Are Involved in Otic Capsule Formation and Epithelial–Mesenchymal Signaling in the Developing Chicken Inner Ear

2002 ◽  
Vol 251 (2) ◽  
pp. 380-394 ◽  
Author(s):  
Weise Chang ◽  
Peter ten Dijke ◽  
Doris K. Wu
Keyword(s):  
Inner Ear ◽  
Otic Capsule ◽  
Capsule Formation

Epithelial—mesenchymal tissue interactions guiding otic capsule formation: the role of the otocyst

Development ◽  
1986 ◽  
Vol 97 (1) ◽  
pp. 1-24
Author(s):  
Joseph R. McPhee ◽  
Thomas R. Van De Water
Keyword(s):  
Mouse Embryo ◽  
Mouse Embryos ◽  
In Vitro Studies ◽  
Otic Capsule ◽  
Membranous Labyrinth ◽  
Capsule Formation ◽  
Tissue Interactions ◽  
Mesenchymal Tissue

The otocyst is the epithelial anlage of the membranous labyrinth which interacts with surrounding cephalic mesenchyme to form an otic capsule. A series of in vitro studies was performed to gain a better understanding of the epithelial—mesenchymal interactions involved in this process. Parallel series of otocyst/mesenchyme (O/M) and isolated periotic mesenchyme (M) explants provided morphological and biochemical data to define the role of the otocyst in organizing and directing formation of its cartilaginous otic capsule. Explants were made from mouse embryos ranging in age from 10 to 14 days of gestation, and organ cultured under identical conditions until the chronological equivalent of 16 days of gestation. Expression of chrondrogenesis was determined by both histology and biochemistry. The in vitro behaviour of periotic mesenchyme explanted either with or without an otocyst supports several hypotheses that explain aspects of otic capsule development. The results indicate that (a) prior to embryonic day 12 the otocyst alone is not sufficient to stimulate chondrogenesis of the otic capsule within O/M explants; (b) the otocyst acts as an inductor of capsule chondrogenesis within O/M explants between embryonic days 12 to 13; (c) isolated mesenchyme within M explants taken from 13-day-old embryos are capable of initiating in vitro chondrogenesis, but without expressing capsule morphology in the absence of the otocyst; and (d) the isolated mesenchyme of M explants obtained from 14-day-old embryos expresses both chondrogenesis and otic capsule morphology in the absence of the otocyst. These findings suggest that the otocyst acts as an inductor of chondrogenesis of periotic mesenchyme tissue between embryonic days 11 to 13, and controls capsular morphogenesis between embryonic days 13 to 14 in the mouse embryo.

Hyaluronate production by the inner ear during otic capsule and perilymphatic space formation

1987 ◽  
Vol 8 (5) ◽  
pp. 265-272 ◽  
Author(s):  
Joseph R. McPhee ◽  
Thomas R. Van De Water ◽  
Hung-Xi Su
Keyword(s):  
Inner Ear ◽  
Otic Capsule ◽  
Perilymphatic Space

Transforming growth factor β1 is an epithelial-derived signal peptide that influences otic capsule formation

1992 ◽  
Vol 153 (2) ◽  
pp. 324-336 ◽  
Author(s):  
Dorothy A. Frenz ◽  
Vera Galinovic-Schwartz ◽  
Wei Liu ◽  
Kathleen C. Flanders ◽  
Thomas R. Van de Water
Keyword(s):  
Growth Factor ◽  
Signal Peptide ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Otic Capsule ◽  
Capsule Formation

X-ray microtomography study of otic capsule deficiencies: three-dimensional modelling of the fissula ante fenestram

2015 ◽  
Vol 129 (9) ◽  
pp. 840-851 ◽  
Author(s):  
J W Lee ◽  
P Sale ◽  
N P Patel
Keyword(s):  
Inner Ear ◽  
Three Dimensional ◽  
Oval Window ◽  
Otic Capsule ◽  
X Ray ◽  
Otologic Surgery ◽  
Science Group ◽  
Temporal Bones ◽  
The Relationship ◽  
Non Destructive

AbstractBackground:The postulated sites of perilymph fistulae involve otic capsule deficiencies, in particular, at the fissula ante fenestram. Histological studies have revealed this to be a channel extending from the middle ear, and becoming continuous with the inner ear medial to the anterior limit of the oval window. The relationship between a patent fissula and symptoms of perilymph fistula is contentious.Objective:The understanding of the anatomy of the fissula ante fenestram is incomplete. Histopathology is inherently destructive to the delicate ultrastructure of the middle and inner ear. Conversely, X-ray microtomography allows non-destructive examination of the otic capsule. In this study, we used X-ray microtomography to characterise the fissula ante fenestram.Materials and methods:We imaged cadaveric temporal bones with X-ray microtomography. We used the Avizo Fire (Visualization Science Group, Merignac Cedex, France) software to perform post-processing and image analysis.Results:Three-dimensional modelling of the fissula ante fenestram allowed stratification into four forms: rudimentary pit; partial fissula; complete occluded fissula; and complete patent fissula.Conclusion:X-ray microtomography showed that the fissula ante fenestram is present in various forms from rudimentary pit to complete deficiency of the otic capsule. This understanding may have implications for otologic surgery and clinical diagnosis of perilymph fistula.

scholarly journals Sonic Hedgehog Regulates Otic Capsule Chondrogenesis and Inner Ear Development in the Mouse Embryo

2002 ◽  
Vol 248 (2) ◽  
pp. 240-250 ◽  
Author(s):  
W. Liu ◽  
G. Li ◽  
J.S. Chien ◽  
S. Raft ◽  
H. Zhang ◽  
...  
Keyword(s):  
Inner Ear ◽  
Sonic Hedgehog ◽  
Mouse Embryo ◽  
Otic Capsule ◽  
Ear Development ◽  
Inner Ear Development

Osteoprotegerin in the Inner Ear May Inhibit Bone Remodeling in the Otic Capsule

2005 ◽  
Vol 115 (1) ◽  
pp. 172-177 ◽  
Author(s):  
Andreas F. Zehnder ◽  
Arthur G. Kristiansen ◽  
Joe C. Adams ◽  
Saumil N. Merchant ◽  
Michael J. McKenna
Keyword(s):  
Inner Ear ◽  
Bone Remodeling ◽  
Otic Capsule
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