scholarly journals Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

2001 ◽  
Vol 229 (1) ◽  
pp. 163-175 ◽  
Author(s):  
Marta I. Gallego ◽  
Nadine Binart ◽  
Gertraud W. Robinson ◽  
Ryugo Okagaki ◽  
Karen T. Coschigano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mammary Tissue ◽  
Developmental Effects ◽  
Epidermal Growth

Interaction of Growth Hormone-Releasing Factor and Somatostatin on Ulcer Healing and Mucosal Growth in Rats: Role of Gastrin and Epidermal Growth Factor

Digestion ◽  
1988 ◽  
Vol 41 (3) ◽  
pp. 121-128 ◽  
Author(s):  
S.J. Konturek ◽  
T. Brzozowski ◽  
A. Dembinski ◽  
Z. Warzecha ◽  
P.K. Konturek ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Ulcer Healing ◽  
Growth Hormone Releasing Factor ◽  
Epidermal Growth ◽  
Mucosal Growth

Changes in protein metabolism of ovine primary muscle cultures on treatment with growth hormone, insulin, insulin-like growth factor I or epidermal growth factor

1987 ◽  
Vol 112 (1) ◽  
pp. 87-96 ◽  
Author(s):  
J. M. M. Harper ◽  
J. B. Soar ◽  
P. J. Buttery
Keyword(s):  
Growth Hormone ◽  
Protein Synthesis ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Muscle Cultures ◽  
Epidermal Growth ◽  
Growth Factor I ◽  
High Concentrations

ABSTRACT Methods for the primary culture of muscle cells from fetal sheep were developed which gave high yields of cells. Myoblasts were grown in vitro, and allowed to fuse to form contractile multinucleate myotubes; these could be maintained in a good condition for at least 2 weeks. Protein turnover in these differentiated cultures was examined for sensitivity to each of four potentially anabolic peptide hormones and growth factors: insulin, insulin-like growth factor I (somatomedin C), epidermal growth factor and growth hormone. Insulin was found to have no effect except at high concentrations (1 μmol/l), compatible with its role as a somatomedin analogue. Insulin-like growth factor I was active at lower levels (1 nmol/l) but the cultures were not as responsive to it as were primary rat muscle cultures or differentiated L6 cells, which were tested in similar experiments. The maximum stimulation of protein synthesis observed with the ruminant system was only 16%. Epidermal growth factor was highly anabolic for primary cultures from sheep muscle, and the cells were very sensitive to it, half-maximal stimulation of protein synthesis being seen with concentrations as low as 20 pmol/l. No effects of bovine growth hormone were seen in the ovine system. However, an inhibition of protein breakdown was found with high concentrations (0·1 μmol/l) in the L6 rat myoblast cell line. It was found that the culture conditions used could affect the observed responses of protein synthesis and degradation, despite withdrawal of serum from the incubation media 22 h before testing. J. Endocr. (1987) 112, 87–96

Epidermal Growth Factor Stimulates Growth Hormone Secretion from Superfused Rat Adenohypophyseal Fragments

Endocrinology ◽  
1984 ◽  
Vol 115 (2) ◽  
pp. 556-558 ◽  
Author(s):  
HITOSHI IKEDA ◽  
TOMOAKI MITSUHASHI ◽  
KEN KUBOTA ◽  
NOBUAKI KUZUYA ◽  
HIDEMASA UCHIMURA
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Epidermal Growth

Expression of epidermal growth factor receptor (EGFR) in non-affected and tumorous mammary tissue of female dogs

1994 ◽  
Vol 30 (2) ◽  
pp. 139-146 ◽  
Author(s):  
G. R. Rutteman ◽  
J. A. Foekens ◽  
H. Portengen ◽  
J. H. Vos ◽  
M. A. Blankenstein ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Mammary Tissue ◽  
Epidermal Growth
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