scholarly journals Expression and Function of Members of a Divergent Nuclear Receptor Family in Caenorhabditis elegans

1999 ◽  
Vol 215 (2) ◽  
pp. 314-331 ◽  
Author(s):  
Tomoyuki Miyabayashi ◽  
Mark T Palfreyman ◽  
Ann E Sluder ◽  
Frank Slack ◽  
Piali Sengupta
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Receptor ◽  
Nuclear Receptor Family ◽  
And Function ◽  
Receptor Family

scholarly journals Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Laurent L’homme ◽  
Benan Pelin Sermikli ◽  
Olivier Molendi-Coste ◽  
Sébastien Fleury ◽  
Sandrine Quemener ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Nuclear Receptor ◽  
High Fat Diet ◽  
Cell Function ◽  
Retinoic Acid Receptor ◽  
Orphan Receptor ◽  
Nuclear Receptor Family ◽  
Receptor Family ◽  
Diet Model

AbstractRetinoic acid receptor-related orphan receptor-alpha (RORα) is a transcription factor from the nuclear receptor family expressed by immune cells and involved in the development of obesity, insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). It was recently reported that mice deficient for RORα in macrophages develop more severe NASH upon high fat diet (HFD) feeding due to altered Kupffer cell function. To better understand the role of RORα in obesity and IR, we independently generated a macrophage RORα-deficient mouse line. We report that RORα deletion in macrophages does not impact on HFD-induced obesity and IR. Surprisingly, we did not confirm an effect on NASH development upon HFD feeding nor in the more severe and obesity-independent choline-deficient, L-amino acid-defined diet model. Our results therefore show that RORα deletion in macrophages does not alter the development of obesity and IR and question its role in NASH.

scholarly journals Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans

2004 ◽  
Vol 266 (2) ◽  
pp. 399-416 ◽  
Author(s):  
Chris R. Gissendanner ◽  
Kirsten Crossgrove ◽  
Kelly A. Kraus ◽  
Claude V. Maina ◽  
Ann E. Sluder
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Receptor ◽  
And Function

Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family

1999 ◽  
Vol 155 (1-2) ◽  
pp. 51-60 ◽  
Author(s):  
Azriel Schmidt ◽  
Robert Vogel ◽  
M.Katharine Holloway ◽  
Su Jane Rutledge ◽  
Oren Friedman ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Nuclear Receptor ◽  
Transcription Control ◽  
Nuclear Receptor Family ◽  
Receptor Family

Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis

2010 ◽  
Vol 38 (2) ◽  
pp. 201-209 ◽  
Author(s):  
Anat Achiron ◽  
Itamar Grotto ◽  
Ran Balicer ◽  
David Magalashvili ◽  
Anna Feldman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nuclear Receptor ◽  
Microarray Analysis ◽  
Family Members ◽  
Disease State ◽  
Altered Regulation ◽  
Nuclear Receptor Family ◽  
Receptor Family

scholarly journals Estrogen receptors and function in the male reproductive system

2009 ◽  
Vol 53 (8) ◽  
pp. 923-933 ◽  
Author(s):  
Maria Fatima Magalhães Lazari ◽  
Thais Fabiana Gameiro Lucas ◽  
Fabiana Yasuhara ◽  
Gisele Renata Oliveira Gomes ◽  
Erica Rosanna Siu ◽  
...  
Keyword(s):  
Growth Factors ◽  
Estrogen Receptors ◽  
Reproductive System ◽  
Male Reproductive System ◽  
Estrogen Signaling ◽  
Nuclear Receptor Family ◽  
And Function ◽  
Rapid Signaling ◽  
G Protein Coupled ◽  
Receptor Family

A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERα and ERβ, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. In addition to the well established transcriptional effects, estrogens can mediate rapid signaling, triggered within seconds or minutes. These rapid effects can be mediated by ESRs or the G protein-coupled estrogen receptor GPER, also known as GPR30. The effects of estrogen on cell proliferation, differentiation and apoptosis are often mediated by growth factors. The understanding of the cross-talk between androgen, estrogen and growth factors signaling pathways is therefore essential to understand the physiopathological mechanisms of estrogen action. In this review we focused on recent discoveries about the nature of the estrogen receptors, and on the signaling and function of estrogen in the male reproductive system.

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