scholarly journals Cloning of Rat Fibrillin-2 cDNA and Its Role in Branching Morphogenesis of Embryonic Lung

1999 ◽  
Vol 212 (1) ◽  
pp. 229-242 ◽  
Author(s):  
Qiwei Yang ◽  
Kosuke Ota ◽  
Yufeng Tian ◽  
Anil Kumar ◽  
Jun Wada ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Embryonic Lung

PDGF-AA and its receptor influence early lung branching via an epithelial-mesenchymal interaction

Development ◽  
1995 ◽  
Vol 121 (8) ◽  
pp. 2559-2567 ◽  
Author(s):  
P. Souza ◽  
M. Kuliszewski ◽  
J. Wang ◽  
I. Tseu ◽  
A.K. Tanswell ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Critical Role ◽  
Polymerase Chain Reaction Analysis ◽  
Branching Morphogenesis ◽  
Inhibitory Effect ◽  
Embryonic Lung ◽  
Morphometric Analyses ◽  
Terminal Buds ◽  
Lung Branching

The biological role of platelet-derived growth factor (PDGF)-AA in lung morphogenesis was investigated by incubating embryonic lung explants with phosphorothioate antisense PDGF-A oligonucleotides, which decreased PDGF-AA but not PDGF-BB protein content. Antisense PDGF-A oligonucleotides inhibited DNA synthesis. This inhibitory effect of antisense PDGF-A was reversed by the addition of exogenous PDGF-AA but not PDGF-BB. Morphometric analyses of antisense-treated cultures showed a significant reduction in lung size. The number of terminal buds of the lung explants was significantly decreased by antisense PDGF-A oligonucleotides. PDGF-AA but not PDGF-BB attenuated the inhibitory effect of antisense PDGF-A on early lung branching. Sense PDGF-A had no effect on DNA synthesis and early lung branching. Reverse transcriptase-polymerase chain reaction analysis revealed PDGF-A mRNA expression in the epithelial component of the embryonic lung, while message for PDGF alpha-receptor was expressed in the mesenchyme. Incubation of explants with neutralizing PDGF-AA antibodies also reduced DNA synthesis and early branching morphogenesis. We conclude that PDGF-AA and its receptor represent an important epithelial-mesenchymal interaction which plays a critical role in early lung branching morphogenesis.

Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension

2005 ◽  
Vol 232 (2) ◽  
pp. 268-281 ◽  
Author(s):  
Kimberly A. Moore ◽  
Tom Polte ◽  
Sui Huang ◽  
Bin Shi ◽  
Eben Alsberg ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Branching Morphogenesis ◽  
Membrane Remodeling ◽  
Embryonic Lung ◽  
Cytoskeletal Tension

scholarly journals NPAS1 Regulates Branching Morphogenesis in Embryonic Lung

2007 ◽  
Vol 36 (4) ◽  
pp. 427-434 ◽  
Author(s):  
Bernadette M. Levesque ◽  
Shutang Zhou ◽  
Lin Shan ◽  
Pamela Johnston ◽  
Yanping Kong ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Embryonic Lung

scholarly journals Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung

2005 ◽  
Vol 277 (2) ◽  
pp. 316-331 ◽  
Author(s):  
Stijn P. De Langhe ◽  
Frédéric G. Sala ◽  
Pierre-Marie Del Moral ◽  
Timothy J. Fairbanks ◽  
Kenneth M. Yamada ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Branching Morphogenesis ◽  
Embryonic Lung ◽  
Dickkopf 1 ◽  
Major Target

scholarly journals miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution

2009 ◽  
Vol 333 (2) ◽  
pp. 238-250 ◽  
Author(s):  
Gianni Carraro ◽  
Ahmed El-Hashash ◽  
Diego Guidolin ◽  
Caterina Tiozzo ◽  
Gianluca Turcatel ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Embryonic Lung ◽  
Lung Epithelial ◽  
E Cadherin

The Mouse Embryonic Lung: A Biological Example of Branching Morphogenesis

2001 ◽  
pp. 211-223
Author(s):  
S. Bellusci ◽  
A. Mailleux ◽  
D. Ndiaye ◽  
J.-P. Thiery
Keyword(s):  
Branching Morphogenesis ◽  
Embryonic Lung
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