scholarly journals The Expression Pattern of Thyroid Hormone Response Genes in Remodeling Tadpole Tissues Defines Distinct Growth and Resorption Gene Expression Programs

1998 ◽  
Vol 203 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Deborah L. Berry ◽  
Christopher S. Rose ◽  
Benjamin F. Remo ◽  
Donald D. Brown
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Expression Pattern ◽  
Hormone Response

scholarly journals β-Trace Gene Expression Is Regulated by a Core Promoter and a Distal Thyroid Hormone Response Element

1997 ◽  
Vol 272 (22) ◽  
pp. 14387-14393 ◽  
Author(s):  
David M. White ◽  
Teiji Takeda ◽  
Leslie J. DeGroot ◽  
Kari Stefansson ◽  
Barry G. W. Arnason
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Core Promoter ◽  
Hormone Response ◽  
Response Element ◽  
Hormone Response Element ◽  
Thyroid Hormone Response Element

scholarly journals Different Configurations of Specific Thyroid Hormone Response Elements Mediate Opposite Effects of Thyroid Hormone and GC-1 on Gene Expression

Endocrinology ◽  
2005 ◽  
Vol 146 (11) ◽  
pp. 4926-4933 ◽  
Author(s):  
Bernd Gloss ◽  
Gisele Giannocco ◽  
Eric A. Swanson ◽  
Anselmo S. Moriscot ◽  
Grazia Chiellini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Hormone Response ◽  
Response Elements ◽  
Hormone Response Elements

scholarly journals Thyroid Hormone and COUP-TF1 Regulate Kallikrein-Binding Protein (KBP) Gene Expression

Endocrinology ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 1143-1153 ◽  
Author(s):  
Yan-Yun Liu ◽  
Teruyo Nakatani ◽  
Takahiko Kogai ◽  
Kaizeen Mody ◽  
Gregory A. Brent
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Binding Protein ◽  
Orphan Nuclear Receptor ◽  
Hormone Response ◽  
Kinin System ◽  
Response Elements ◽  
Hormone Response Elements

Kallikrein-binding protein (KBP) is a component of the kallikrein-kinin system that mediates vasodilation and inhibits tumor growth by antagonizing vascular endothelial growth factor-mediated angiogenesis. We demonstrate that KBP gene expression is repressed by T3 and modulated by the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1). In hypothyroid mice, KBP mRNA expression in the testis was increased 2.1-fold compared with euthyroid mice. We have identified two negative thyroid hormone response elements (nTREs) in the mouse KBP gene, nTRE1 located in the 5′ flanking region (−53 to −29) and nTRE2, located in the first intron (104–132). We used functional assays, cofactor knockdown, and chromatin immunoprecipitation assays to characterize nTRE1 and nTRE2 in hepatic (HepG2) and testes (GC-1spg) cell lines. Reporter expression directed by both elements was enhanced with addition of thyroid hormone receptor and repressed with the addition of T3. COUP-TF1 enhanced basal expression of both elements but blunted unliganded thyroid hormone receptor enhancement and T3 repression of nTRE1 but not nTRE2. Both nTREs bound nuclear corepressor and binding increased in response to T3. Nuclear corepressor knockdown resulted in loss of T3 repression of both nTRE1 and nTRE2. COUP-TF1, which usually represses T3 induction of positive thyroid hormone response elements, reverses T3 repression mediated by nTRE1 in the mouse KBP gene. Endogenous KBP expression is repressed by T3 and two functional nTREs, both of which are required, have been characterized in the KBP gene. COUP-TF1 may be an important factor to modulate expression of genes that are repressed by T3.

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