scholarly journals The Genetic Sequence of Retinal Development in the Ciliary Margin of theXenopusEye

1998 ◽  
Vol 199 (2) ◽  
pp. 185-200 ◽  
Author(s):  
Muriel Perron ◽  
Shami Kanekar ◽  
Monica L. Vetter ◽  
William A. Harris
Keyword(s):  
Retinal Development ◽  
Genetic Sequence ◽  
Ciliary Margin

The role of ADAM 9/15 in mouse retinal development

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
Z Yang ◽  
F Pfister ◽  
F vom Hagen ◽  
J Tatsios ◽  
Y Feng ◽  
...  
Keyword(s):  
Retinal Development

Personality Genetics

2018 ◽  
Author(s):  
Jaime Derringer
Keyword(s):  
Cultural Context ◽  
Behavior Genetics ◽  
Genetic Research ◽  
Reliability And Validity ◽  
Experimental Manipulation ◽  
Sequence Information ◽  
Natural Experiments ◽  
Genetic Sequence ◽  
Form And Function ◽  
Causal Pathway

Although correlations between personality and health are consistently observed, often the causal pathway, or even the direction of effect, is unknown. Genes provide an additional node of information which may be included to help clarify the relationship between personality and health. Genetically informative studies, whether focused on family-identified relationships or specific genotypes, provide clear benefits to disentangling causal processes. Genetic measures approach near universal reliability and validity: processes of inheritance are consistent across cultures, geography, and time, such that similar models and instruments may be applied to incredibly diverse populations. Although frequency and intercorrelations differ by ancestry background (Novembre et al., 2008) and cultural context (Tucker-Drob & Bates, 2016) may exert powerful moderating effects, fundamental form and function is consistent across all members of our species, and even many other species. Genetic sequence information is also of course highly temporally stable, and possesses temporal precedence. That is, the literal genetic sequence is lifetime-stable and comes before all other experiences. Human behavior genetic research, like most personality research, faces limitations in terms of causal inferences that may be made in the absence of experimental manipulation. But behavior genetics takes advantage of natural experiments: populations that differ in terms of genetic similarity (either inferred – such as twins – or measured – such as genotyping methods) to begin to unravel the complex influences on individual differences in personality and health outcomes.

Misexpression of cNSCL1 Disrupts Retinal Development

1999 ◽  
Vol 14 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Chuan-Ming Li ◽  
Run-Tao Yan ◽  
Shu-Zhen Wang
Keyword(s):  
Retinal Development

An error-correcting code framework for genetic sequence analysis

2004 ◽  
Vol 341 (1-2) ◽  
pp. 89-109 ◽  
Author(s):  
Elebeoba E. May ◽  
Mladen A. Vouk ◽  
Donald L. Bitzer ◽  
David I. Rosnick
Keyword(s):  
Sequence Analysis ◽  
Error Correcting Code ◽  
Genetic Sequence ◽  
Genetic Sequence Analysis

scholarly journals perfectphyloR: An R package for reconstructing perfect phylogenies

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Charith B. Karunarathna ◽  
Jinko Graham
Keyword(s):  
Binary Tree ◽  
Sequence Data ◽  
R Package ◽  
Binary Sequences ◽  
Ancestral Haplotype ◽  
Perfect Phylogeny ◽  
Nested Partitions ◽  
Genetic Sequence ◽  
Insight Into ◽  
Rooted Binary Tree

Abstract Background A perfect phylogeny is a rooted binary tree that recursively partitions sequences. The nested partitions of a perfect phylogeny provide insight into the pattern of ancestry of genetic sequence data. For example, sequences may cluster together in a partition indicating that they arise from a common ancestral haplotype. Results We present an R package to reconstruct the local perfect phylogenies underlying a sample of binary sequences. The package enables users to associate the reconstructed partitions with a user-defined partition. We describe and demonstrate the major functionality of the package. Conclusion The package should be of use to researchers seeking insight into the ancestral structure of their sequence data. The reconstructed partitions have many applications, including the mapping of trait-influencing variants.

scholarly journals Effects of intra-gene fitness interactions on the benefit of sexual recombination

2006 ◽  
Vol 34 (4) ◽  
pp. 560-561 ◽  
Author(s):  
R.A. Watson ◽  
D.M. Weinreich ◽  
J. Wakeley
Keyword(s):  
Nucleotide Sequence ◽  
Point Mutation ◽  
Sequence Space ◽  
Fitness Effect ◽  
Epistatic Interactions ◽  
Genetic Sequence ◽  
High Fitness ◽  
Sexual Recombination ◽  
Evolutionary Trajectories ◽  
Asexual Populations

Whereas spontaneous point mutation operates on nucleotides individually, sexual recombination manipulates the set of nucleotides within an allele as an essentially particulate unit. In principle, these two different scales of variation enable selection to follow fitness gradients in two different spaces: in nucleotide sequence space and allele sequence space respectively. Epistasis for fitness at these two scales, between nucleotides and between genes, may be qualitatively different and may significantly influence the advantage of mutation-based and recombination-based evolutionary trajectories respectively. We examine scenarios where the genetic sequence within a gene strongly influences the fitness effect of a mutation in that gene, whereas epistatic interactions between sites in different genes are weak or absent. We find that, in cases where beneficial alleles of a gene differ from one another at several nucleotide sites, sexual populations can exhibit enormous benefit compared with asexual populations: not only discovering fit genotypes faster than asexual populations, but also discovering high-fitness genotypes that are effectively not evolvable in asexual populations.

scholarly journals Genomic Analysis of Mouse Retinal Development

PLoS Biology ◽  
2004 ◽  
Vol 2 (9) ◽  
pp. e247 ◽  
Author(s):  
Seth Blackshaw ◽  
Sanjiv Harpavat ◽  
Jeff Trimarchi ◽  
Li Cai ◽  
Haiyan Huang ◽  
...  
Keyword(s):  
Retinal Development ◽  
Genomic Analysis
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