scholarly journals Role of Basic FGF and Oxygen in Control of Proliferation, Survival, and Neuronal Differentiation in Carotid Body Chromaffin Cells

1997 ◽  
Vol 184 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Colin A. Nurse ◽  
Cathy Vollmer
Keyword(s):  
Neuronal Differentiation ◽  
Carotid Body ◽  
Chromaffin Cells ◽  
Basic Fgf

scholarly journals Tcf4 Is Involved in Subset Specification of Mesodiencephalic Dopaminergic Neurons

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 317
Author(s):  
Simone Mesman ◽  
Iris Wever ◽  
Marten P. Smidt
Keyword(s):  
Neuronal Differentiation ◽  
Dopaminergic Neurons ◽  
Neuronal Development ◽  
Neuronal Population ◽  
Minor Role ◽  
Initial Increase ◽  
E Box ◽  
A Minor ◽  
Bhlh Factor

During development, mesodiencephalic dopaminergic (mdDA) neurons form into different molecular subsets. Knowledge of which factors contribute to the specification of these subsets is currently insufficient. In this study, we examined the role of Tcf4, a member of the E-box protein family, in mdDA neuronal development and subset specification. We show that Tcf4 is expressed throughout development, but is no longer detected in adult midbrain. Deletion of Tcf4 results in an initial increase in TH-expressing neurons at E11.5, but this normalizes at later embryonic stages. However, the caudal subset marker Nxph3 and rostral subset marker Ahd2 are affected at E14.5, indicating that Tcf4 is involved in correct differentiation of mdDA neuronal subsets. At P0, expression of these markers partially recovers, whereas expression of Th transcript and TH protein appears to be affected in lateral parts of the mdDA neuronal population. The initial increase in TH-expressing cells and delay in subset specification could be due to the increase in expression of the bHLH factor Ascl1, known for its role in mdDA neuronal differentiation, upon loss of Tcf4. Taken together, our data identified a minor role for Tcf4 in mdDA neuronal development and subset specification.

Dual role of calbindin-D28Kin vesicular catecholamine release from mouse chromaffin cells

2006 ◽  
Vol 99 (2) ◽  
pp. 628-640 ◽  
Author(s):  
R. H. S. Westerink ◽  
M. B. Rook ◽  
J. P. Beekwilder ◽  
W. J. Wadman
Keyword(s):  
Chromaffin Cells ◽  
Dual Role ◽  
Catecholamine Release

Predominant role of peripheral chemoreceptors in the termination of apnea in maturing newborn lambs

1996 ◽  
Vol 80 (3) ◽  
pp. 892-898 ◽  
Author(s):  
C. Delacourt ◽  
E. Canet ◽  
M. A. Bureau
Keyword(s):  
Carotid Body ◽  
Pco2 Level ◽  
Peripheral Chemoreceptor ◽  
Arterial Pco2 ◽  
Postnatal Maturation ◽  
Body Function ◽  
Life Threatening ◽  
Prolonged Apnea ◽  
Arterial Po2

Apneas are very common and normal in newborns but may become life threatening if they are not terminated appropriately. The aim of this study in newborn lambs was to investigate the influence on apnea termination of postnatal maturation, peripheral chemoreceptor function, and hypoxia. Apneas were induced by passive hyperventilation at varying inspired O2 fraction levels. The apnea termination threshold PCO2 (PATTCO2) was defined as the arterial PCO2 value at the first breath after the apnea. Three groups of awake intubated lambs were studied: 1) intact lambs tested at both 1 and 15 days of life, 2) intact 1-day-old lambs with central tissue hypoxia induced by CO inhalation, and 3) 1-day-old lambs with carotid body denervation (CBD). In individual lambs and regardless of age and carotid body function, there was a PO2-PCO2 response curve that was a determinant for the termination of an apnea. PATTCO2 invariably increased when arterial PO2 increased, regardless of age. During hypoxia and normoxia, PATTCO2 was significantly lower in 15-day-old lambs compared with 1-day-old lambs. No difference was seen during hyperoxia. PATTCO2 values were shifted to higher levels after carotid body removal. Finally, hypoxia induced by either a low inspired O2 fraction or CO inhalation consistently failed to induce a depressive effect on the PATTCO2 even in CBD lambs. In conclusion, in awake newborn lambs, the PCO2 level for apnea termination changed with postnatal age, and carotid body function was essential in lowering PATTCO2, thus protecting the lambs against prolonged apnea. Furthermore, hypoxia consistently failed to depress the reinitiation of breathing after apnea, even in CBD lambs.

scholarly journals Role of TrkB during the postnatal development of the rat carotid body

2015 ◽  
Vol 219 ◽  
pp. 18-24 ◽  
Author(s):  
Ryan W. Bavis ◽  
Halward J. Blegen ◽  
Sarah Logan ◽  
Sarah C. Fallon ◽  
Amy B. McDonough
Keyword(s):  
Postnatal Development ◽  
Carotid Body

The Role of GM1 and Other Gangliosides in Neuronal Differentiation Overview and New Findingsa

1998 ◽  
Vol 845 (1 SPHINGOLIPIDS) ◽  
pp. 161-175 ◽  
Author(s):  
Robert W. Ledeen ◽  
Gusheng Wu ◽  
Zi-Hua Lu ◽  
Diane Kozireski-Chuback ◽  
Yu Fang
Keyword(s):  
Neuronal Differentiation
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