scholarly journals Laminin and Heparan Sulfate Proteoglycan Mediate Epithelial Cell Polarization in Organotypic Cultures of Embryonic Lung Cells: Evidence Implicating Involvement of the Inner Globular Region of Laminin β 1 Chain and the Heparan Sulfate Groups of Heparan Sulfate Proteoglycan

1996 ◽  
Vol 179 (1) ◽  
pp. 264-273 ◽  
Author(s):  
Lucia Schuger ◽  
Amy P.N. Skubitz ◽  
Kevin Gilbride ◽  
Richard Mandel ◽  
Li He
Keyword(s):  
Epithelial Cell ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Cell Polarization ◽  
Lung Cells ◽  
Sulfate Proteoglycan ◽  
Embryonic Lung ◽  
Organotypic Cultures

scholarly journals Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes.

1989 ◽  
Vol 109 (6) ◽  
pp. 3199-3211 ◽  
Author(s):  
A Heremans ◽  
B van der Schueren ◽  
B de Cock ◽  
M Paulsson ◽  
J J Cassiman ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Monoclonal Antibodies ◽  
Epithelial Cell ◽  
Heparan Sulfate ◽  
Core Protein ◽  
Structural Features ◽  
Heparan Sulfate Proteoglycan ◽  
Basement Membranes ◽  
Lung Fibroblasts ◽  
Sulfate Proteoglycan

Cultured human lung fibroblasts produce a large, nonhydrophobic heparan sulfate proteoglycan that accumulates in the extracellular matrix of the monolayer (Heremans, A., J. J. Cassiman, H. Van den Berghe, and G. David. 1988. J. Biol. Chem. 263: 4731-4739). A panel of four monoclonal antibodies, specific for four distinct epitopes on the 400-kD core protein of this extracellular matrix heparan sulfate proteoglycan, detects similar proteoglycans in human epithelial cell cultures. Immunohistochemistry of human tissues with the monoclonal antibodies reveals that these proteoglycans are concentrated at cell-matrix interfaces. Immunogold labeling of ultracryosections of human skin indicates that the proteoglycan epitopes are nonhomogeneously distributed over the width of the basement membrane. Immunochemical investigations and amino acid sequence analysis indicate that the proteoglycan from the fibroblast matrix shares several structural features with the large, low density heparan sulfate proteoglycan isolated from the Engelbreth-Holm-Swarm sarcoma. Thus, both epithelial cell sheets and individual mesenchymal cells accumulate a large heparan sulfate proteoglycan(s) at the interface with the interstitial matrix, where the proteoglycan may adopt a specific topological orientation with respect to this matrix.

Alterations in the basement membrane (heparan sulfate) proteoglycan in diabetic mice

Diabetes ◽  
1982 ◽  
Vol 31 (2) ◽  
pp. 185-188 ◽  
Author(s):  
D. H. Rohrbach ◽  
J. R. Hassell ◽  
H. K. Kleinman ◽  
G. R. Martin
Keyword(s):  
Basement Membrane ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Diabetic Mice

Targeting Mechanism of a Novel Liver-targeting Interferon IFN-CSP Involves Liver Heparan Sulfate Proteoglycan

2016 ◽  
Vol 13 (4) ◽  
pp. 528-533 ◽  
Author(s):  
Xuemei Lu ◽  
Jie Wang ◽  
Xiaobao Jin ◽  
Yanting Huang ◽  
Wenting Zeng ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Liver Targeting

Immunohistochemical Study of Heparan Sulfate Proteoglycan in Adenocarcinomas of the Pancreas

Pancreas ◽  
1994 ◽  
Vol 9 (6) ◽  
pp. 758-763 ◽  
Author(s):  
Zhao-hui Wang ◽  
Tadao Manabe ◽  
Gakuji Ohshio ◽  
Takashi Imamura ◽  
Tsunehiro Yoshimura ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Immunohistochemical Study ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

scholarly journals Fatty acylation of heparan sulfate proteoglycan from human colon carcinoma cells.

1990 ◽  
Vol 265 (32) ◽  
pp. 19980-19989
Author(s):  
R V Iozzo ◽  
I Kovalszky ◽  
N Hacobian ◽  
P K Schick ◽  
J S Ellingson ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Heparan Sulfate Proteoglycan ◽  
Carcinoma Cells ◽  
Sulfate Proteoglycan ◽  
Fatty Acylation ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma

scholarly journals Identification of cDNA clones encoding different domains of the basement membrane heparan sulfate proteoglycan.

1988 ◽  
Vol 263 (31) ◽  
pp. 16379-16387 ◽  
Author(s):  
D M Noonan ◽  
E A Horigan ◽  
S R Ledbetter ◽  
G Vogeli ◽  
M Sasaki ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Cdna Clones ◽  
Sulfate Proteoglycan
Sign in / Sign up

Export Citation Format

Share Document