scholarly journals ADAM, a Widely Distributed and Developmentally Regulated Gene Family Encoding Membrane Proteins with A̱Ḏisintegrin A̱nd M̱etalloprotease Domain

1995 ◽  
Vol 169 (1) ◽  
pp. 378-383 ◽  
Author(s):  
Tyra G. Wolfsberg ◽  
Paul D. Straight ◽  
Robyn L. Gerena ◽  
Ari-Pekka J. Huovila ◽  
Paul Primakoff ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Gene Family ◽  
Developmentally Regulated

scholarly journals Developmentally regulated Drosophila gene family encoding the fork head domain.

1992 ◽  
Vol 89 (18) ◽  
pp. 8754-8758 ◽  
Author(s):  
U. Hacker ◽  
U. Grossniklaus ◽  
W. J. Gehring ◽  
H. Jackle
Keyword(s):  
Gene Family ◽  
Developmentally Regulated ◽  
Drosophila Gene ◽  
Fork Head ◽  
Head Domain

Multiple regulatory genes control expression of a gene family during development of Dictyostelium discoideum

1986 ◽  
Vol 6 (12) ◽  
pp. 4353-4361
Author(s):  
S Alexander ◽  
A M Cibulsky ◽  
S D Cuneo
Keyword(s):  
Gene Family ◽  
Dictyostelium Discoideum ◽  
Regulatory Genes ◽  
Developmental Expression ◽  
Developmentally Regulated ◽  
Suppressor Activity ◽  
Normal Expression ◽  
Mutant Strains ◽  
Complementation Groups ◽  
In Trans

Mutant strains of Dictyostelium discoideum carrying dis mutations fail to transcribe specifically the family of developmentally regulated discoidin lectin genes during morphogenesis. The phenotypes of these mutants strongly suggested that the mutations reside in regulatory genes. Using these mutant strains, we showed that multiple regulatory genes are required for the expression of the lectin structural genes and that these regulatory genes (the dis+ alleles) act in trans to regulate this gene family. These regulatory genes fall into two complementation groups (disA and disB) and map to linkage groups II and III, respectively. A further regulatory locus was defined by the identification of an unlinked supressor gene, drsA (discoidin restoring), which is epistatic to disB, but not disA, and results in the restoration of lectin expression in cells carrying the disB mutation. Mutant cells carrying the drsA allele express the discoidin lectin gene family during growth and development, in contrast to wild-type cells which express it only during development. Therefore, the suppressor activity of the drsA allele appears to function by making the expression of the discoidin lectins constitutive and no longer strictly developmentally regulated. The data indicate that normal expression of the discoidin lectins is dependent on the sequential action of the disB+, drsA+, and disA+ gene products. Thus, we described an interacting network of regulatory genes which in turn controls the developmental expression of a family of genes during the morphogenesis of D. discoideum.

The electroneutral cation-chloride cotransporters.

1998 ◽  
Vol 201 (14) ◽  
pp. 2091-2102 ◽  
Author(s):  
D B Mount ◽  
E Delpire ◽  
G Gamba ◽  
A E Hall ◽  
E Poch ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Gene Family ◽  
Molecular Identification ◽  
Membrane Topology ◽  
Cytoplasmic Domains ◽  
Transmembrane Segments ◽  
Novel Gene ◽  
Lower Eukaryotes ◽  
Homologous Genes ◽  
Cation Chloride Cotransporters

Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter proteins share a common predicted membrane topology, with twelve putative transmembrane segments flanked by long hydrophilic N- and C-terminal cytoplasmic domains. The molecular identification of these transporters has had a significant impact on the study of their function, regulation and pathophysiology.

scholarly journals Variation of tandem repeats in the developmentally regulated procyclic acidic repetitive proteins of Trypanosoma brucei.

1989 ◽  
Vol 9 (3) ◽  
pp. 1332-1335 ◽  
Author(s):  
M R Mowatt ◽  
G S Wisdom ◽  
C E Clayton
Keyword(s):  
Gene Family ◽  
Trypanosoma Brucei ◽  
Tandem Repeats ◽  
Surface Proteins ◽  
Northern Hybridization ◽  
Developmentally Regulated ◽  
Coordinate Regulation ◽  
Polymorphic Genes ◽  
Alpha Gene ◽  
Carboxy Terminal

The procyclic acidic repetitive proteins (PARPs) of Trypanosoma brucei are developmentally regulated surface proteins encoded by a family of polymorphic genes. We have determined the complete nucleotide sequence of a novel member of the PARP gene family and investigated its expression. The amino acid sequence deduced from the parpA alpha gene showed a marked conservation of both the amino- and carboxy-terminal regions compared with other PARPs but revealed the substitution of a pentapeptide for the dipeptide repeating unit that is characteristic of all other PARPs. Northern hybridization analysis indicated that expression of the parpA alpha gene, like that of other members of this gene family, is confined to the procyclic stage of the T. brucei life cycle. This result implies coordinate regulation of the unlinked genetic loci that encode PARPs.

Characterization of a stress-induced, developmentally regulated gene family from soybean

1992 ◽  
Vol 18 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Dring N. Crowell ◽  
Maliyakal E. John ◽  
David Russell ◽  
Richard M. Amasino
Keyword(s):  
Gene Family ◽  
Developmentally Regulated

scholarly journals Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 89 ◽  
Author(s):  
Iain W Chalmers ◽  
Andrew J McArdle ◽  
Richard MR Coulson ◽  
Marissa A Wagner ◽  
Ralf Schmid ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Schistosoma Mansoni ◽  
Gene Family ◽  
Developmentally Regulated ◽  
Regulated Expression ◽  
Venom Allergen

scholarly journals Multiple regulatory genes control expression of a gene family during development of Dictyostelium discoideum.

1986 ◽  
Vol 6 (12) ◽  
pp. 4353-4361 ◽  
Author(s):  
S Alexander ◽  
A M Cibulsky ◽  
S D Cuneo
Keyword(s):  
Gene Family ◽  
Dictyostelium Discoideum ◽  
Regulatory Genes ◽  
Developmental Expression ◽  
Developmentally Regulated ◽  
Suppressor Activity ◽  
Normal Expression ◽  
Mutant Strains ◽  
Complementation Groups ◽  
In Trans

Mutant strains of Dictyostelium discoideum carrying dis mutations fail to transcribe specifically the family of developmentally regulated discoidin lectin genes during morphogenesis. The phenotypes of these mutants strongly suggested that the mutations reside in regulatory genes. Using these mutant strains, we showed that multiple regulatory genes are required for the expression of the lectin structural genes and that these regulatory genes (the dis+ alleles) act in trans to regulate this gene family. These regulatory genes fall into two complementation groups (disA and disB) and map to linkage groups II and III, respectively. A further regulatory locus was defined by the identification of an unlinked supressor gene, drsA (discoidin restoring), which is epistatic to disB, but not disA, and results in the restoration of lectin expression in cells carrying the disB mutation. Mutant cells carrying the drsA allele express the discoidin lectin gene family during growth and development, in contrast to wild-type cells which express it only during development. Therefore, the suppressor activity of the drsA allele appears to function by making the expression of the discoidin lectins constitutive and no longer strictly developmentally regulated. The data indicate that normal expression of the discoidin lectins is dependent on the sequential action of the disB+, drsA+, and disA+ gene products. Thus, we described an interacting network of regulatory genes which in turn controls the developmental expression of a family of genes during the morphogenesis of D. discoideum.

Characterization of a tissue-specific and developmentally regulated β-1,3-glucanase gene family in Prunus persica

2003 ◽  
Vol 41 (11-12) ◽  
pp. 955-963 ◽  
Author(s):  
Tae-Seok Ko ◽  
Sangman Lee ◽  
Scott C. Schaefer ◽  
Schuyler S. Korban
Keyword(s):  
Gene Family ◽  
Prunus Persica ◽  
Developmentally Regulated ◽  
Tissue Specific
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