scholarly journals Both Basic Fibroblast Growth Factor and Ciliary Neurotrophic Factor Promote the Retention of Polyneuronal Innervation of Developing Skeletal Muscle Fibers

1995 ◽  
Vol 169 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Arthur Wm. English ◽  
Gail Schwartz
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Neurotrophic Factor ◽  
Muscle Fibers ◽  
Ciliary Neurotrophic Factor ◽  
Fibroblast Growth ◽  
Skeletal Muscle Fibers ◽  
Polyneuronal Innervation

scholarly journals Fibroblast growth factor-21 potentiates glucose transport in skeletal muscle fibers

2020 ◽  
Vol 65 (3) ◽  
pp. 85-95
Author(s):  
G Rosales-Soto ◽  
A Diaz-Vegas ◽  
M Casas ◽  
A Contreras-Ferrat ◽  
E Jaimovich
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Glucose Uptake ◽  
Fibroblast Growth Factor ◽  
Glucose Transport ◽  
Muscle Fibers ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Skeletal Muscle Fibers ◽  
Pkc Ζ

Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism. Although FGF21 has been associated with glucose metabolism in skeletal muscle cells, its cellular mechanism in adult skeletal muscle fibers glucose uptake is poorly understood. In the present study, we found that FGF21 induced a dose−response effect, increasing glucose uptake in skeletal muscle fibers from the flexor digitorum brevis muscle of mice, evaluated using the fluorescent glucose analog 2-NBDG (300 µM) in single living fibers. This effect was prevented by the use of either cytochalasin B (5 µM) or indinavir (100 µM), both antagonists of GLUT4 activity. The use of PI3K inhibitors such as LY294002 (50 µM) completely prevented the FGF21-dependent glucose uptake. In fibers electroporated with the construct encoding GLUT4myc-eGFP chimera and stimulated with FGF21 (100 ng/mL), a strong sarcolemmal GLUT4 label was detected. This effect promoted by FGF21 was demonstrated to be dependent on atypical PKC-ζ, by using selective PKC inhibitors. FGF21 at low concentrations potentiated the effect of insulin on glucose uptake but at high concentrations, completely inhibited the uptake in the presence of insulin. These results suggest that FGF21 regulates glucose uptake by a mechanism mediated by GLUT4 and dependent on atypical PKC-ζ in skeletal muscle.

Distribution of acidic fibroblast growth factor-like immunoreactivity in rat skeletal muscle fibers

1996 ◽  
Vol 707 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Tanja Junttila ◽  
Leena Rechardt ◽  
Yihai Cao ◽  
Tomas Hökfelt ◽  
Markku Pelto-Huikko
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Muscle Fibers ◽  
Fibroblast Growth ◽  
Rat Skeletal Muscle ◽  
Acidic Fibroblast Growth Factor ◽  
Skeletal Muscle Fibers

scholarly journals Fibroblast Growth Factor 21 Promotes Glucose Uptake in Adult Skeletal Muscle Fibers from Mice

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Giovanni Rosales‐Soto ◽  
Alexis Díaz‐Vegas ◽  
Paola Llanos ◽  
Enrique Jaimovich ◽  
Ariel Contreras‐Ferrat
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Glucose Uptake ◽  
Fibroblast Growth Factor ◽  
Muscle Fibers ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Adult Skeletal Muscle ◽  
Skeletal Muscle Fibers
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