Retinoic Acid Selectively Promotes the Survival and Proliferation of Neurogenic Precursors in Cultured Neural Crest Cell Populations

1994 ◽  
Vol 161 (1) ◽  
pp. 243-250 ◽  
Author(s):  
Paul D. Henion ◽  
James A. Weston
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Populations ◽  
Crest Cell

Analysis of developmentally homogeneous neural crest cell populations in vitro

1981 ◽  
Vol 82 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Jeanne Loring ◽  
Bengt Glimelius ◽  
Carol Erickson ◽  
James A. Weston
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Populations ◽  
Crest Cell

scholarly journals Sox10ERT2CreERT2mice enable tracing of distinct neural crest cell populations

2015 ◽  
Vol 244 (11) ◽  
pp. 1394-1403 ◽  
Author(s):  
Fenglei He ◽  
Philippe Soriano
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Populations ◽  
Crest Cell

scholarly journals FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk

2011 ◽  
Vol 194 (3) ◽  
pp. 489-503 ◽  
Author(s):  
Patricia L. Martínez-Morales ◽  
Ruth Diez del Corral ◽  
Isabel Olivera-Martínez ◽  
Alejandra C. Quiroga ◽  
Raman M. Das ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Epithelial Mesenchymal Transition ◽  
Neural Crest Cell ◽  
Fibroblast Growth ◽  
Loss Of Function ◽  
Mesenchymal Transition ◽  
Morphogenetic Protein ◽  
Trunk Neural Crest ◽  
Crest Cell

Coordination between functionally related adjacent tissues is essential during development. For example, formation of trunk neural crest cells (NCCs) is highly influenced by the adjacent mesoderm, but the molecular mechanism involved is not well understood. As part of this mechanism, fibroblast growth factor (FGF) and retinoic acid (RA) mesodermal gradients control the onset of neurogenesis in the extending neural tube. In this paper, using gain- and loss-of-function experiments, we show that caudal FGF signaling prevents premature specification of NCCs and, consequently, premature epithelial–mesenchymal transition (EMT) to allow cell emigration. In contrast, rostrally generated RA promotes EMT of NCCs at somitic levels. Furthermore, we show that FGF and RA signaling control EMT in part through the modulation of elements of the bone morphogenetic protein and Wnt signaling pathways. These data establish a clear role for opposition of FGF and RA signaling in control of the timing of NCC EMT and emigration and, consequently, coordination of the development of the central and peripheral nervous system during vertebrate trunk elongation.

scholarly journals Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos

2002 ◽  
Vol 117 (1-2) ◽  
pp. 115-122 ◽  
Author(s):  
Xiaobing Jiang ◽  
Bibha Choudhary ◽  
Esther Merki ◽  
Kenneth R Chien ◽  
Robert E Maxson ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Retinoic Acid Receptor ◽  
Cell Lineage ◽  
Neural Crest Cell ◽  
Acid Receptor ◽  
Cardiac Neural Crest ◽  
Receptor Mutant ◽  
Crest Cell

scholarly journals PDGF function in diverse neural crest cell populations

2010 ◽  
Vol 4 (4) ◽  
pp. 561-566 ◽  
Author(s):  
Christopher L. Smith ◽  
Michelle D. Tallquist
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Populations ◽  
Crest Cell
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