DIFFERENTIAL REGULATION OF MACROPHAGE CCAAT-ENHANCER BINDING PROTEIN ISOFORMS BY LIPOPOLYSACCHARIDE AND CYTOKINES

Cytokine ◽  
2000 ◽  
Vol 12 (9) ◽  
pp. 1430-1436 ◽  
Author(s):  
Tengku S Tengku-Muhammad ◽  
Timothy R Hughes ◽  
Harri Ranki ◽  
Anthony Cryer ◽  
Dipak P Ramji
Keyword(s):  
Binding Protein ◽  
Differential Regulation ◽  
Protein Isoforms ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

scholarly journals Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution

1998 ◽  
Vol 334 (1) ◽  
pp. 205-210 ◽  
Author(s):  
Georgios SABATAKOS ◽  
Gareth E. DAVIES ◽  
Maria GROSSE ◽  
Anthony CRYER ◽  
Dipak P. RAMJI
Keyword(s):  
Transcription Factors ◽  
Mammary Gland ◽  
Dna Binding ◽  
Binding Protein ◽  
Mouse Mammary Gland ◽  
Binding Activity ◽  
Protein Isoforms ◽  
Dna Binding Activity ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

Transcription factors belonging to the CCAAT-enhancer binding protein (C/EBP) family have been implicated in the activation of gene expression in the mammary gland during lactation. We have therefore investigated the detailed expression profile of the C/EBP family during lactation and involution of the mouse mammary gland. The expression of C/EBPβ and C/EBPδ mRNA was low during lactation, increased dramatically at the beginning of involution and remained constant thereafter. In contrast, C/EBPα mRNA expression was relatively high during the early stages of lactation, declined to low levels during the late stages of lactation and at the start of involution, and increased again during involution. Electrophoretic mobility-shift assays showed a close correlation between the expression of the C/EBP genes and the functional C/EBP DNA-binding activity and, additionally, demonstrated the participation of heterodimers, formed from among the three proteins, in DNA–protein interactions. The DNA-binding activity of the activator protein 1 (AP1) family of transcription factors was also induced during involution. These results therefore point to potentially important regulatory roles for both the C/EBP and the AP1 family during lactation and involution of the mammary gland.

scholarly journals CCAAT/Enhancer binding protein isoforms expression in the colon of neonatal mice

1995 ◽  
Vol 204 (1) ◽  
pp. 66-76 ◽  
Author(s):  
Sylvie Blais ◽  
François Boudreau ◽  
Jean-françois Beaulieu ◽  
Claude Asselin
Keyword(s):  
Binding Protein ◽  
Protein Isoforms ◽  
Neonatal Mice ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

scholarly journals Role of Specific CCAAT/Enhancer-binding Protein Isoforms in Intestinal Epithelial Cells

2001 ◽  
Vol 276 (47) ◽  
pp. 44331-44337 ◽  
Author(s):  
Ionela Gheorghiu ◽  
Claude Deschênes ◽  
Mylène Blais ◽  
François Boudreau ◽  
Nathalie Rivard ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Binding Protein ◽  
Protein Isoforms ◽  
Intestinal Epithelial ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein
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