THE ROLE OF CYTOKINES AND RETINOIC ACID IN THE REGULATION OF HUMAN THYROID CANCER CELL GROWTH

Cytokine ◽  
1998 ◽  
Vol 10 (7) ◽  
pp. 536-539 ◽  
Author(s):  
Jen-Der Lin ◽  
Tzu-Chieh Chao ◽  
Hsiao-Fen Weng ◽  
Koan-Day Lin
Keyword(s):  
Thyroid Cancer ◽  
Retinoic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Thyroid ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Effect of 22-Oxa-1,25-Dihydroxyvitamin D3 on Human Thyroid Cancer Cell Growth.

1999 ◽  
Vol 46 (2) ◽  
pp. 243-252 ◽  
Author(s):  
KUNIHIKO OKANO ◽  
TOSHIRO USA ◽  
AURA OHTSURU ◽  
TOMOO TSUKAZAKI ◽  
YOUICHI MIYAZAKI ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Thyroid ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Growth ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Resveratrol inhibits metastatic follicular thyroid cancer cell growth

2009 ◽  
Vol 209 (3) ◽  
pp. S126 ◽  
Author(s):  
Susan Clare Pitt ◽  
Ruth J. Davis ◽  
Scott N. Pinchot ◽  
Herbert Chen
Keyword(s):  
Thyroid Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Thyroid Cancer Cell ◽  
Follicular Thyroid Cancer ◽  
Cancer Cell Growth

scholarly journals miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1

2019 ◽  
Vol 47 (1) ◽  
pp. 548-554 ◽  
Author(s):  
Guochang Wu ◽  
Haitao Zheng ◽  
Jie Xu ◽  
Yawen Guo ◽  
Guibin Zheng ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Thyroid ◽  
Thyroid Cancer Cell

8-Cl-cAMP and PKA I-selective cAMP analogs effectively inhibit undifferentiated thyroid cancer cell growth

Endocrine ◽  
2016 ◽  
Vol 56 (2) ◽  
pp. 388-398
Author(s):  
Elisa Stellaria Grassi ◽  
Alessandra Dicitore ◽  
Irene Negri ◽  
Maria Orietta Borghi ◽  
Giovanni Vitale ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Growth ◽  
Undifferentiated Thyroid Cancer

scholarly journals The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress

2012 ◽  
Vol 214 (2) ◽  
pp. 207-216 ◽  
Author(s):  
Joanna Klubo-Gwiezdzinska ◽  
Kirk Jensen ◽  
Andrew Bauer ◽  
Aneeta Patel ◽  
John Costello ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Thyroid Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Translocator Protein ◽  
Human Thyroid ◽  
Thyroid Cancer Cell ◽  
Thyroid Cancer Cell Lines

The translocator protein (TSPO), formerly known as a peripheral benzodiazepine receptor, exerts pro-apoptotic function via regulation of mitochondrial membrane potential. We examined TSPO expression in human thyroid tumors (25 follicular adenomas (FA), 15 follicular cancers (FC), and 70 papillary cancers (PC)). The role of TSPO in the regulation of cell growth, migration, and apoptosis was examined in thyroid cancer cell lines after TSPO knockdown with siRNA and after treatment with TSPO antagonist (PK11195). Compared with normal thyroid, the level of TSPO expression was increased in FA, FC, and PC in 24, 26.6, and 55.7% of cases respectively. Thyroid cancer cell lines demonstrated variable levels of TSPO expression, without specific association with thyroid oncogene mutations. Treatment with inhibitors of PI3K/AKT or MEK/ERK signaling was not associated with changes in TSPO expression. Treatment with histone deacetylase inhibitor (valproic acid) increased TSPO expression in TSPO-deficient cell lines (FTC236 cells). TSPO gene silencing or treatment with PK11195 did not affect thyroid cancer cell growth and migration but prevented depolarization of mitochondrial membranes induced by oxidative stress. Induction of TSPO expression by valproic acid was associated with increased sensitivity of FTC236 to oxidative stress-inducible apoptosis. Overall, we showed that TSPO expression is frequently increased in PC. In vitro data suggested the role of epigenetic mechanism(s) in the regulation of TSPO in thyroid cells. Implication of TSPO in the thyroid cancer cell response to oxidative stress suggested its potential role in the regulation of thyroid cancer cell response to treatment with radioiodine and warrants further investigation.

scholarly journals miR-126-3p Inhibits Thyroid Cancer Cell Growth and Metastasis, and Is Associated with Aggressive Thyroid Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0130496 ◽  
Author(s):  
Yin Xiong ◽  
Shweta Kotian ◽  
Martha A. Zeiger ◽  
Lisa Zhang ◽  
Electron Kebebew
Keyword(s):  
Thyroid Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Growth
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