Investigation of the Mechanism and the Effect of Cryoimmunology in the Copenhagen Rat

Cryobiology ◽  
2001 ◽  
Vol 42 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Nathan E. Hoffmann ◽  
James E. Coad ◽  
Christopher S. Huot ◽  
David J. Swanlund ◽  
John C. Bischof
Keyword(s):  
Copenhagen Rat

Cryo, Hyper or Both? Investigating Combination Cryo/Hyperthermia in the Dorsal Skin Flap Chamber

2000 ◽  
Author(s):  
Nathan E. Hoffmann ◽  
Bo H. Chao ◽  
John C. Bischof
Keyword(s):  
Combination Therapy ◽  
Thermal History ◽  
Standard Treatment ◽  
Tissue Injury ◽  
Skin Flap ◽  
Dorsal Skin ◽  
Combination Therapies ◽  
Disease Treatment ◽  
Copenhagen Rat

Abstract Combination therapies have been investigated as a mean to increase efficacy of disease treatment. For example, combinations such as radiation and chemotherapy, surgery and chemotherapy, and two different chemotherapies have become standard treatment for most cancers. Current theories suggest that vascular-mediated injury is an important mechanism of cryosurgical (reviewed in Gage and Baust (1998)) and hyperthermic destruction (Badylak et al., 1985; Dudar and Jain, 1984) in the treatment of solid tumors. These techniques appear complementary. Freezing creates vascular damage and promotes stasis within the vessels (Rabb et al., 1974), whereas hyperthermia creates cell and vascular destruction more effectively with a compromised vasculature (Shakil et al., 1999). Thus, in this study, we investigated the effect of combining these therapies on the vascular and tissue injury from the two therapies. We chose the dorsal skin flap chamber (DSFC) implanted in the Copenhagen rat as the cryosurgical model for this study. This in vivo freezing model allowed us to monitor thermal history and investigate both vascular and tissue injury in response to the combination therapy.

MRI/MRS OF DUNNING PROSTATE TUMORS IN THE SKIN PEDICLE OF THE COPENHAGEN RAT

1991 ◽  
pp. 470
Author(s):  
PP ANTICH ◽  
P PESCHKE ◽  
RP MASON ◽  
E BABCOCK ◽  
A CONSTANTINESCU ◽  
...  
Keyword(s):  
Prostate Tumors ◽  
Copenhagen Rat

scholarly journals Effect of Homeopathic Treatment on Gene Expression in Copenhagen Rat Tumor Tissues

2006 ◽  
Vol 5 (4) ◽  
pp. 350-355 ◽  
Author(s):  
Rajesh L. Thangapazham ◽  
N. V. Rajeshkumar ◽  
Anuj Sharma ◽  
Jim Warren ◽  
Anoop K. Singh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Homeopathic Treatment ◽  
Tumor Tissues ◽  
Copenhagen Rat ◽  
Rat Tumor
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