Alteration in Expression of β2 Integrins on Lamina Propria Lymphocytes in Ulcerative Colitis and Crohn's Disease

2002 ◽  
Vol 104 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Charles N. Bernstein ◽  
Michael Sargent ◽  
Edward Rector
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Lamina Propria Lymphocytes ◽  
Β2 Integrins

scholarly journals Immunolocalization of leptin and leptin receptor in colorectal mucosa of ulcerative colitis, Crohn’s disease and control subjects with no inflammatory bowel disease

2020 ◽  
Author(s):  
Flavia Merigo ◽  
Alessandro Brandolese ◽  
Sonia Facchin ◽  
Federico Boschi ◽  
Marzia Di Chio ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Leptin Receptor ◽  
Gastrointestinal Symptoms ◽  
Lymphatic Vessels ◽  
Mucosal Inflammation ◽  
Colorectal Mucosa ◽  
Inflammatory Bowel

Abstract The expression of leptin and leptin receptor (Ob-R) has been partially elucidated in colon of patients with inflammatory bowel diseases (IBDs), even though leptin is involved in angiogenesis and inflammation. We previously reported overexpression of GLUT5 fructose transporter, in aberrant clusters of lymphatic vessels in lamina propria of IBD and controls. Here, we examine leptin and Ob-R expression in the same biopsies. Specimens were obtained from patients with ulcerative colitis (UC), Crohn’s disease (CD) and controls who underwent screening for colorectal cancer, follow-up after polypectomy or with a history of lower gastrointestinal symptoms. Immunohistochemistry revealed leptin in apical and basolateral membranes of short epithelial portions, Ob-R on the apical pole of epithelial cells. Leptin and Ob-R were also identified in structures and cells scattered in the lamina propria. In UC, a significant correlation between leptin and Ob-R in the lamina propria was found in all inflamed samples, beyond non-inflamed samples of the proximal tract, while in CD, it was found in inflamed distal samples. Most of the leptin and Ob-R positive areas in the lamina propria were also GLUT5 immunoreactive in inflamed and non-inflamed mucosa. A significant correlation of leptin or Ob-R expression with GLUT5 was observed in the inflamed distal samples from UC. Our findings suggest that there are different sites of leptin and Ob-R expression in large intestine and those in lamina propria do not reflect the status of mucosal inflammation. The co-localization of leptin and/or Ob-R with GLUT5 may indicate concomitance effects in colorectal lamina propria areas.

Crossover Subsets of CD4+ T Lymphocytes in the Intestinal Lamina Propria of Patients with Crohn’s Disease and Ulcerative Colitis

2017 ◽  
Vol 62 (9) ◽  
pp. 2357-2368 ◽  
Author(s):  
Ji Li ◽  
Aito Ueno ◽  
Marietta Iacucci ◽  
Miriam Fort Gasia ◽  
Humberto B. Jijon ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
T Lymphocytes ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Intestinal Lamina Propria

Zinc downregulates IL-2 production by lamina propria lymphocytes in Crohn's disease

1995 ◽  
Vol 108 (4) ◽  
pp. A881
Author(s):  
GE Mullin ◽  
GM Reddy ◽  
Y Kuang ◽  
R Cerchia ◽  
SE Fisher ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Lamina Propria Lymphocytes

scholarly journals Disturbances in apoptosis of lamina propria lymphocytes in Crohn’s disease

2015 ◽  
Vol 6 ◽  
pp. 1279-1285 ◽  
Author(s):  
Piotr Eder ◽  
Liliana Łykowska-Szuber ◽  
Iwona Krela-Kaźmierczak ◽  
Kamila Stawczyk-Eder ◽  
Katarzyna Iwanik ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Lamina Propria Lymphocytes

scholarly journals A66 CHARACTERIZATION OF PERIPHERAL BLOOD AND LAMINA PROPRIA LYMPHOCYTES IN CROHN’S DISEASE.

2018 ◽  
Vol 1 (suppl_2) ◽  
pp. 104-105
Author(s):  
N Power ◽  
T Jeyalingam ◽  
M Filice ◽  
M Smith ◽  
M S Silverberg ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Peripheral Blood ◽  
Lamina Propria Lymphocytes
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