Humoral and Cell-Mediated Immunity in Mice with Genetic Deficiencies of Prolactin, Growth Hormone, Insulin-like Growth Factor-I, and Thyroid Hormone

2000 ◽  
Vol 96 (2) ◽  
pp. 140-149 ◽  
Author(s):  
Melanie P. Foster ◽  
Eric R. Jensen ◽  
Encarnacion Montecino-Rodriguez ◽  
Hyosuk Leathers ◽  
Nelson Horseman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Thyroid Hormone ◽  
Cell Mediated Immunity ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: comparison with growth hormone

1996 ◽  
Vol 134 (5) ◽  
pp. 563-567 ◽  
Author(s):  
Mehboob A Hussain ◽  
Ole Schmitz ◽  
Jens OL Jorgensen ◽  
Jens S Christiansen ◽  
Jorgen Weeke ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Thyroid Hormone ◽  
Healthy Subjects ◽  
Insulin Like Growth Factor ◽  
Hormone Metabolism ◽  
Thyroid Hormone Metabolism ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Hussain MA, Schmitz O, Jorgensen JOL, Christiansen JS, Weeke J, Schmid C, Froesch ER. Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans. Eur J Endocrinol 1996;134:563–7. ISSN 0804–4643 Insulin-like growth factor I (IGF-I) is considered to mediate some of the growth-promoting and metabolic effects of growth hormone (GH). Growth hormone treatment of healthy and GH-deficient subjects is accompanied by increased conversion of thyroxine (T4) to triiodothyronine (T3) in peripheral tissues. Whether these effects are mediated by IGF-I is unknown. To assess the respective roles of these hormones on thyroid hormone metabolism we have treated two groups of subjects. The first group consisted of eight healthy subjects who were treated with IGF-I 10 μg·kg−1·h−1 sc for 5 days). The second group consisted of eight subjects with combined GH and thyrotropin (TSH) deficiency due to acquired pituitary disease. They were treated with IGF-I (10 μg·kg−1·h−1 sc for 7 days), GH (2 IU m−2 sc q.i.d.) or both hormones together. The IGF-I treatment in healthy subjects led to an increase in free T3 (FT3) and a reduction in TSH levels, whereas FT4 and total T4 (TT4) levels remained unchanged. In the second group—in which all subjects were substituted with oral lthyroxine—treatment with IGF-I led to an elevation of FT3 in the face of unchanged T4 levels. Growth hormone alone and GH plus IGF-I resulted in a more pronounced elevation in T3 level. The results suggest that IGF-I partially mediates the well-known effects of GH on peripheral conversion of T4 to T3. However, GH has more pronounced effects on thyroid hormones that apparently are not mediated by IGF-I. ER Froesch, Division of Endocrinology and Metabolism, Department of Internal Medicine, University Hospital of Zürich, Rámistr, 100, 8091 Zürich, Switzerland

Insulin-like growth factor-I restores the reduced somatostatinergic tone controlling growth hormone secretion in cirrhotic rats

2001 ◽  
Vol 21 (6) ◽  
pp. 405-409 ◽  
Author(s):  
Inma Castilla-Cortázar ◽  
M. Aurelia Aliaga-Montilla ◽  
Javier Salvador ◽  
María García ◽  
Gloria Delgado ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Effects of environmental salinity on somatic growth and growth hormone/insulin-like growth factor-I axis in juvenile tilapia Oreochromis mossambicus

2007 ◽  
Vol 73 (5) ◽  
pp. 1025-1034 ◽  
Author(s):  
Sameh MAGDELDIN ◽  
Katsuhisa UCHIDA ◽  
Tetsuya HIRANO ◽  
E Gordon GRAU ◽  
Ahmed ABDELFATTAH ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Somatic Growth ◽  
Oreochromis Mossambicus ◽  
Insulin Like Growth Factor ◽  
Environmental Salinity ◽  
Factor I ◽  
Growth Factor I
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