Effect of Topical Fluticasone Propionate on the Mucosal Allergic Response Induced by Ragweed Allergen and Diesel Exhaust Particle Challenge

1999 ◽  
Vol 90 (3) ◽  
pp. 313-322 ◽  
Author(s):  
David Diaz-Sanchez ◽  
Albert Tsien ◽  
Jennifer Fleming ◽  
Andrew Saxon
Keyword(s):  
Fluticasone Propionate ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particle ◽  
Allergic Response

scholarly journals Diesel Exhaust Particle Exposure Compromises Alveolar Macrophage Mitochondrial Bioenergetics

2019 ◽  
Vol 20 (22) ◽  
pp. 5598
Author(s):  
Jonathan L. Gibbs ◽  
Blake W. Dallon ◽  
Joshua B. Lewis ◽  
Chase M. Walton ◽  
Juan A. Arroyo ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Diesel Exhaust ◽  
Critical Role ◽  
Cell Communication ◽  
Diesel Exhaust Particle ◽  
Diesel Exhaust Particles ◽  
The Body ◽  
Whole Body ◽  
H2o2 Production ◽  
Pulmonary Macrophages

Diesel exhaust particles (DEPs) are known pathogenic pollutants that constitute a significant quantity of air pollution. Given the ubiquitous presence of macrophages throughout the body, including the lungs, as well as their critical role in tissue and organismal metabolic function, we sought to determine the effect of DEP exposure on macrophage mitochondrial function. Following daily DEP exposure in mice, pulmonary macrophages were isolated for mitochondrial analyses, revealing reduced respiration rates and dramatically elevated H2O2 levels. Serum ceramides and inflammatory cytokines were increased. To determine the degree to which the changes in mitochondrial function in macrophages were not dependent on any cross-cell communication, primary pulmonary murine macrophages were used to replicate the DEP exposure in a cell culture model. We observed similar changes as seen in pulmonary macrophages, namely diminished mitochondrial respiration, but increased H2O2 production. Interestingly, when treated with myriocin to inhibit ceramide biosynthesis, these DEP-induced mitochondrial changes were mitigated. Altogether, these data suggest that DEP exposure may compromise macrophage mitochondrial and whole-body function via pathologic alterations in macrophage ceramide metabolism.

scholarly journals Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles

2014 ◽  
Vol 5 (1) ◽  
pp. 35-41 ◽  
Author(s):  
David Heber ◽  
Zhaoping Li ◽  
Maria Garcia-Lloret ◽  
Angela M. Wong ◽  
Tsz Ying (Amy) Lee ◽  
...  
Keyword(s):  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Allergic Response ◽  
Exhaust Particles ◽  
Broccoli Sprout

scholarly journals Diesel exhaust particle role on gut microbiome and onset of Alzheimer disease neuroinflammation

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Sean X Naughton ◽  
Susan Westfall ◽  
Giulio Maria Pasinetti
Keyword(s):  
Alzheimer Disease ◽  
Diesel Exhaust ◽  
Gut Microbiome ◽  
Diesel Exhaust Particle

scholarly journals Alteration of intracellular cysteine and glutathione levels in alveolar macrophages and lymphocytes by diesel exhaust particle exposure.

2002 ◽  
Vol 110 (4) ◽  
pp. 349-353 ◽  
Author(s):  
Nabil H Al-Humadi ◽  
Paul D Siegel ◽  
Daniel M Lewis ◽  
Mark W Barger ◽  
Jane Y C Ma ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particle ◽  
Particle Exposure ◽  
Diesel Exhaust Particle Exposure

Diesel exhaust particle exposure increases severity of allergic asthma in young mice

2013 ◽  
Vol 43 (12) ◽  
pp. 1406-1418 ◽  
Author(s):  
T. H. Acciani ◽  
E. B. Brandt ◽  
G. K. Khurana Hershey ◽  
T. D. Le Cras
Keyword(s):  
Allergic Asthma ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particle ◽  
Particle Exposure ◽  
Diesel Exhaust Particle Exposure ◽  
Young Mice

scholarly journals Regulation of Human Hepatic Drug Transporter Activity and Expression by Diesel Exhaust Particle Extract

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121232 ◽  
Author(s):  
Marc Le Vee ◽  
Elodie Jouan ◽  
Bruno Stieger ◽  
Valérie Lecureur ◽  
Olivier Fardel
Keyword(s):  
Diesel Exhaust ◽  
Diesel Exhaust Particle ◽  
Drug Transporter ◽  
Hepatic Drug
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