Vigorous Peripheral Blood Cytotoxic T Cell Response during the Acute Phase of Hepatitis C Virus Infection

2000 ◽  
Vol 203 (2) ◽  
pp. 111-123 ◽  
Author(s):  
Magali Cucchiarini ◽  
Andreas R. Kammer ◽  
Benno Grabscheid ◽  
Helmut M. Diepolder ◽  
Tilman J. Gerlach ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Infection ◽  
Acute Phase ◽  
Peripheral Blood ◽  
Cell Response ◽  
T Cell Response ◽  
Cytotoxic T Cell ◽  
Hepatitis C Virus Infection

HLA footprinting reveals a novel protective CD8 + T cell response in Hepatitis C virus infection

2009 ◽  
Vol 59 (6) ◽  
pp. S428-S429 ◽  
Author(s):  
Karen Fitzmaurice ◽  
Danijela Petrovic ◽  
Silvana Gaudieri ◽  
Elizabeth Freitas ◽  
Stuart Sims ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Infection ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Hepatitis C Virus Infection

T cell response in hepatitis C virus infection

2005 ◽  
Vol 32 (2) ◽  
pp. 75-85 ◽  
Author(s):  
C. Neumann-Haefelin ◽  
H.E. Blum ◽  
F.V. Chisari ◽  
R. Thimme
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Infection ◽  
Cell Response ◽  
T Cell Response ◽  
Hepatitis C Virus Infection

scholarly journals Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus

Hepatology ◽  
1997 ◽  
Vol 25 (2) ◽  
pp. 470-477 ◽  
Author(s):  
O Bruña-Romero ◽  
J J Lasarte ◽  
G Wilkinson ◽  
K Grace ◽  
B Clarke ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Cell Response ◽  
Recombinant Adenovirus ◽  
T Cell Response ◽  
Cytotoxic T Cell

scholarly journals Hepatitis C virus E2 protein encapsulation into poly D, L-lactic-co-glycolide microspheres could induce mice cytotoxic T-cell response

2016 ◽  
Vol Volume 11 ◽  
pp. 5361-5370 ◽  
Author(s):  
Piyachat Roopngam ◽  
Kewei Liu ◽  
Lin Mei ◽  
Yi Zheng ◽  
Xianbing Zhu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cytotoxic T Cell ◽  
Protein Encapsulation ◽  
E2 Protein

scholarly journals Characterization of the Specific CD4+ T Cell Response against the F Protein during Chronic Hepatitis C Virus Infection

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e14237 ◽  
Author(s):  
De-Yong Gao ◽  
Gen-Di Jin ◽  
Bi-Lian Yao ◽  
Dong-Hua Zhang ◽  
Lei-Lei Gu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Heterologous T cell immunity in severe hepatitis C virus infection

2005 ◽  
Vol 201 (5) ◽  
pp. 675-680 ◽  
Author(s):  
Simona Urbani ◽  
Barbara Amadei ◽  
Paola Fisicaro ◽  
Massimo Pilli ◽  
Gabriele Missale ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Infection ◽  
Cell Response ◽  
Cd8 T Cell ◽  
Cross Reactivity ◽  
T Cell Response ◽  
Hcv Infection ◽  
Severe Hepatitis

Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin, L.K. 2004. Immunity. 20:5–16). To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific CD8 T cell response in eight patients with acute HCV infection, two of whom had a particularly severe illness. Patients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073–1081), which cross-reacted with an influenza neuraminidase sequence. Our results suggest that CD8 T cell cross-reactivity influences the severity of the HCV-associated liver pathology and depicts a model of disease induction that may apply to different viral infections.

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