Cross-Reactivity of T-Cell Clones Specific for Altered Peptide Ligands of Myelin Basic Protein

1999 ◽  
Vol 193 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Lara J. Ausubel ◽  
Katarzyna D. Bieganowska ◽  
David A. Hafler
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Cross Reactivity ◽  
Peptide Ligands ◽  
T Cell Clones ◽  
Altered Peptide Ligands ◽  
Cell Clones

Myelin Basic Protein-Reactive Human T-Cell Clones: Stimulation by Diverse Microbial Antigens

1995 ◽  
Vol 756 (1 T-Cell Recept) ◽  
pp. 319-320 ◽  
Author(s):  
J. R. RICHERT ◽  
E. D. ROBINSON ◽  
A. H. JOHNSON ◽  
M. L. COHN ◽  
H. F. MCFARLAND ◽  
...  
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

Murine monoclonal anti-myelin basic protein (MBP) antibodies inhibit proliferation and cytotoxicity of MBP-specific human T cell clones

1989 ◽  
Vol 24 (1-2) ◽  
pp. 87-94 ◽  
Author(s):  
Zhang Jingwu ◽  
Arthur A. Vandenbark ◽  
Marie Paule Jacobs ◽  
Halina Offner ◽  
Jef C.M. Raus
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

scholarly journals Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function

2003 ◽  
Vol 198 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Dong-Gyun Lim ◽  
Jacqueline M. Slavik ◽  
Katarzyna Bourcier ◽  
Kathrine J. Smith ◽  
David A. Hafler
Keyword(s):  
T Cell ◽  
Intracellular Signaling ◽  
Cell Function ◽  
Peptide Ligands ◽  
T Cell Clones ◽  
Altered Peptide Ligands ◽  
Mhc Molecules ◽  
Cell Functions ◽  
T Cell Function ◽  
Cell Clones

T cell receptors recognize small changes in peptide ligands leading to different T cell responses. Here, we analyzed a panel of HLA-A2–Tax11-19 reactive T cell clones to examine how small allelic variations of MHC molecules could alter the functional outcome of antigen recognition. Similar to the effects induced by antigenic altered peptide ligands, weak or partial agonistic T cell functions were identified in individual T cell clones with the recognition of MHC-altered peptide ligands (MAPLs). Interestingly, one subtype of HLA-A2 molecules induced an unusual type of partial agonistic function; proliferation without cytotoxicity. Modeling of crystallographic data indicated that polymorphic amino acids in the HLA-A2 peptide binding groove, especially the D-pocket, were responsible for this partial agonism. Reciprocal mutations of the Tax peptide side chain engaging the D-pocket indeed restored the agonist functions of the MHC–peptide complex. Whereas early intracellular signaling events were not efficiently induced by these MAPLs, phosphorylated c-Jun slowly accumulated with sustained long-term expression. These data indicate that MAPLs can induce atypical partial agonistic T cell function through structural and biochemical mechanisms similar to altered peptide ligands.

Fine specificities of myelin basic protein-specific human T cell clones

1987 ◽  
Vol 16 (1) ◽  
pp. 145 ◽  
Author(s):  
John R. Richert ◽  
Cynthia A. Reuben-Burnside ◽  
Gladys E. Deibler ◽  
Marian W. Kies
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

scholarly journals Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

1985 ◽  
Vol 162 (6) ◽  
pp. 2107-2124 ◽  
Author(s):  
S S Zamvil ◽  
P A Nelson ◽  
D J Mitchell ◽  
R L Knobler ◽  
R B Fritz ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Lymphocytic Infiltration ◽  
Class Ii ◽  
Demyelinating Diseases ◽  
Complex Molecules ◽  
T Cell Clones ◽  
Cell Clones

Class II-restricted T cell clones specific for myelin basic protein (MBP) have been generated from PL/J and (PL/J X SJL/J)F1 [((PLSJ)F1] mice following sensitization to rat MBP. Of 17 T cell clones generated from (PLSJ)F1 mice, 5 are I-Au(A alpha uA beta u) restricted, one is restricted to I-As(A alpha sA beta s), 10 are restricted to hybrid I-A(u X s)F1 (A alpha sA beta u) determinants, and one clone is restricted to hybrid I-E(u X s) (E alpha uE beta s) molecules. Thus, of 16 I-A-restricted T cell clones generated from (PLSJ)F1 mice, only one is I-As-restricted, reflecting a lack of priming to MBP in association with I-As. T cell clones restricted to I-Au and to I-E (E alpha u E beta s) molecules recognize mouse (self) MBP. Furthermore, only the five T cell clones restricted to I-Au molecules recognize a determinant in common with mouse (self) MBP within the encephalitogenic N-terminal peptide. Three such I-Au restricted T cell clones, derived independently, cause paralysis in 100% of (PL/J X SJL/J)F1 mice tested. Acute, chronic unremitting, and chronic relapsing paralysis are all induced following injection of these clones. Administration of greater numbers of cloned T cells causes acute and fatal experimental allergic encephalomyelitis, while administration of lower numbers of cloned T cells is associated with chronic unremitting and relapsing paralysis. Paralysis induced with T cell clones shares many clinical, immunologic, and histologic aspects with human demyelinating diseases such as multiple sclerosis. Histopathology reveals perivascular lymphocytic infiltration, demyelination, and remyelination. These studies demonstrate the utility of T cell clones for analyzing the association between class II major histocompatibility complex molecules and disease susceptibility.

Diversity of T-cell receptor Valpha, Vbeta, and CDR3 expression by myelin basic protein-specific human T-cell clones

Neurology ◽  
1995 ◽  
Vol 45 (10) ◽  
pp. 1919-1922 ◽  
Author(s):  
J. R. Richert ◽  
E.D. Robinson ◽  
K. Camphausen ◽  
R. Martin ◽  
R. R. Voskuhl ◽  
...  
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
T Cell Receptor ◽  
Basic Protein ◽  
Cell Receptor ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients

1990 ◽  
Vol 129 (1) ◽  
pp. 189-198 ◽  
Author(s):  
Zhang Jingwu ◽  
Chi-Hsin J. Chou ◽  
George Hashim ◽  
Robert Medaer ◽  
Jef C.M. Raus
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
T Cell Clones ◽  
Peptide Specificity ◽  
Hla Restriction ◽  
Cell Clones
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