Selectivity of IgE Responses, Mast Cell Sensitization, and Cytokine Expression in the Immune Response of Brown Norway Rats to Chemical Allergens

1996 ◽  
Vol 172 (2) ◽  
pp. 246-253 ◽  
Author(s):  
K.L. Vento ◽  
R.J. Dearman ◽  
I. Kimber ◽  
D.A. Basketter ◽  
J.W. Coleman
Keyword(s):  
Immune Response ◽  
Mast Cell ◽  
Cytokine Expression ◽  
Brown Norway ◽  
Norway Rats

Supplementing docosahexaenoic acid along with arachidonic acid during weaning period improves immune response in neonatal Brown Norway rats

2021 ◽  
Author(s):  
Dhruvesh Patel ◽  
Marnie Newell ◽  
Susan Goruk ◽  
Sue Tsai ◽  
Caroline Richard ◽  
...  
Keyword(s):  
Immune Response ◽  
Arachidonic Acid ◽  
Docosahexaenoic Acid ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats

2016 ◽  
Vol 68 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Hao Wang ◽  
Jaqueline da Silva ◽  
Allan Alencar ◽  
Gisele Zapata-Sudo ◽  
Marina R. Lin ◽  
...  
Keyword(s):  
Mast Cell ◽  
Diastolic Dysfunction ◽  
Cardiac Remodeling ◽  
Brown Norway ◽  
Middle Aged ◽  
Fischer 344 ◽  
Cell Inhibition ◽  
Norway Rats

scholarly journals Effect of a cocoa-enriched diet on immune response and anaphylaxis in a food allergy model in Brown Norway rats

2016 ◽  
Vol 27 ◽  
pp. 317-326 ◽  
Author(s):  
Mar Abril-Gil ◽  
Francisco J. Pérez-Cano ◽  
Àngels Franch ◽  
Margarida Castell
Keyword(s):  
Immune Response ◽  
Food Allergy ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Systemic Release of Mucosal Mast-cell Protease in Primed Brown Norway Rats after Feeding withβ-Lactoglobulin

1995 ◽  
Vol 59 (5) ◽  
pp. 771-775 ◽  
Author(s):  
Hyang Ran Ju ◽  
Izumi Matsuura ◽  
Koji Yamada ◽  
Michihiro Sugano ◽  
Katsumi Imaizumi
Keyword(s):  
Mast Cell ◽  
Brown Norway ◽  
Mucosal Mast Cell ◽  
Mast Cell Protease ◽  
Norway Rats

scholarly journals Attenuating Effect of Peruvian Cocoa Populations on the Acute Asthmatic Response in Brown Norway Rats

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2301
Author(s):  
Marta Périz ◽  
Francisco J. Pérez-Cano ◽  
Trinitat Cambras ◽  
Àngels Franch ◽  
Ivan Best ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Asthma ◽  
Immunoglobulin E ◽  
In Vivo Study ◽  
Brown Norway ◽  
Mast Cell Protease ◽  
Norway Rats ◽  
Anaphylactic Response

Cocoa contains bioactive components, which vary according to genetic and environmental factors. The present study aimed to ascertain the anti-allergic properties of native Peruvian cocoa populations (“Blanco de Piura” or BPC, “Amazonas Peru” or APC, “Criollo de Montaña” or CMC, “Chuncho” or CCC, and an ordinary cocoa or OC). To do so, after an initial in vitro approach, an in vivo study focused on the induction of an anaphylactic response associated with allergic asthma in Brown Norway rats was carried out. Based on their polyphenol content, antioxidant activity and in vitro effects, the APC and CMC were selected to be included in the in vivo study. Cocoa diets were tested in a model of allergic asthma in which anaphylactic response was assessed by changes in body temperature, motor activity and body weight. The concentration of specific immunoglobulin E (IgE), mast cell protease and leukotrienes was also quantified in serum and/or bronchoalveolar lavage fluid. CMC and OC populations exhibited a protective effect on the allergic asthma rat model as evidenced by means of a partial protection against anaphylactic response and, above all, in the synthesis of IgE and the release of mast cell protease.

scholarly journals Motor activity as an unbiased variable to assess anaphylaxis in allergic rats

2015 ◽  
Vol 240 (10) ◽  
pp. 1373-1377 ◽  
Author(s):  
Mar Abril-Gil ◽  
Alba Garcia-Just ◽  
Trinitat Cambras ◽  
Francisco J Pérez-Cano ◽  
Cristina Castellote ◽  
...  
Keyword(s):  
Mast Cell ◽  
Body Temperature ◽  
Motor Activity ◽  
Anaphylactic Shock ◽  
Brown Norway ◽  
Mast Cell Protease ◽  
Specific Immunoglobulin ◽  
Norway Rats ◽  
Anaphylactic Response ◽  
Physiological Systems

The release of mediators by mast cells triggers allergic symptoms involving various physiological systems and, in the most severe cases, the development of anaphylactic shock compromising mainly the nervous and cardiovascular systems. We aimed to establish variables to objectively study the anaphylactic response (AR) after an oral challenge in an allergy model. Brown Norway rats were immunized by intraperitoneal injection of ovalbumin with alum and toxin from Bordetella pertussis. Specific immunoglobulin (Ig) E antibodies were developed in immunized animals. Forty days after immunization, the rats were orally challenged with the allergen, and motor activity, body temperature and serum mast cell protease concentration were determined. The anaphylaxis induced a reduction in body temperature and a decrease in the number of animal movements, which was inversely correlated with serum mast cell protease release. In summary, motor activity is a reliable tool for assessing AR and also an unbiased method for screening new anti-allergic drugs.

Sign in / Sign up

Export Citation Format

Share Document