Antibody Responses to Allergen Lol pIV Are Suppressed Following Adoptive Transfer of B Lymphocytes from the Internal Image Anti-idiotypic Antibody-Treated Mice

1995 ◽  
Vol 165 (1) ◽  
pp. 77-83 ◽  
Author(s):  
En-Min Zhou ◽  
Fred T. Kisil
Keyword(s):  
B Lymphocytes ◽  
Adoptive Transfer ◽  
Antibody Responses ◽  
Internal Image ◽  
Idiotypic Antibody

Polyclonal activation of B lymphocytes during experimental infection with Schistosoma mansoni

Parasitology ◽  
1990 ◽  
Vol 100 (1) ◽  
pp. 83-91 ◽  
Author(s):  
L. M. Lopes ◽  
M. A. C. Pereira ◽  
S. E. Gerken ◽  
N. Vaz
Keyword(s):  
Schistosoma Mansoni ◽  
B Lymphocytes ◽  
Experimental Infection ◽  
Adoptive Transfer ◽  
Cell Activation ◽  
Protein A ◽  
B Cell Activation ◽  
Spleen Cells ◽  
Polyclonal Activation ◽  
Immunoglobulin Isotypes

SummaryA significant polyclonal activation of B lymphocytes was observed during experimental infection of C57BL/10J mice with Schistosoma mansoni. The isotypic pattern of this expansion, assessed by the Protein-A plaque-forming cell method, was compared with and found to differ from those occurring after infection by Trypanosoma cruzi or injection of bacterial LPS. In the infection of S. mansoni an early expansion of most immunoglobulin isotypes occurs together with a late, sustained expansion of IgG1-secreting cells. High levels of polyclonal B cell activation were observed after adoptive transfer of spleen cells from infected mice to isogenic recipients pre-treated with hydroxyurea.

Synergistic Cooperation Between T and B Lymphocytes from Old Mice in the Production of Auto-Anti-Idiotypic Antibody Regulation in Adult Irradiated Hosts

1982 ◽  
Vol 1 (1-2) ◽  
pp. 3-10 ◽  
Author(s):  
Myron R. Szewczuk
Keyword(s):  
B Cells ◽  
B Lymphocytes ◽  
B Lymphocyte ◽  
Intrinsic Property ◽  
Adoptive Cell Transfer ◽  
Cell Transfer ◽  
Lymphocyte Population ◽  
Thymus Cells ◽  
Old Mice ◽  
Idiotypic Antibody

ABSTRACTThe effect of age on the ability of B lymphocytes and thymus cells from donors of various ages to be capable of producing an anti-idiotype-blocked, hapten-augmentable PFC was studied by adoptive cell transfer techniques. Lethally irradiated mice were reconstituted with syngeneic B lymphocytes and thymus cells from donors of various ages. Recipients were immunized with trinitrophenylated bovine gamma globulin (TNP-BGG) one or seven days after cell transfer. Splenic IgG anti-TNP plaque-forming cell (PFC) responses were assayed in the absence and presence of hapten for anti-idiotype (Id)-blocked, hapten-augmentable PFC, 14 days after immunization. It was found that the B lymphocyte population from 2 month old donors together with thymus cells from donors of various ages (2 to 19 months) were incapable of reconstituting mice to produce anti-Id-blocked, hapten-augmentable PFC. Similar results were obtained when mice were reconstituted with thymus cells from 2-month-old donors together with B cells from donors of various ages (2 to 14 months). In contrast, mice reconstituted with B cells plus thymus cells from the same 8-month or older donors produced a significantly high percentage of anti-Id-block, hapten augmentable PFC. Mice reconstituted with B cells from 8 months or older donors plus thymus cells from donors of various ages (8 to 19) months also produced a significantly high percentage of hapten-augmentable PFC. Experiments with B cells and thymus cells from 2-or 8-month old donors parked in lethally irradiated 2-or 8-months old recipients for 7 days revealed that neither lymphocytes from old donors or old recipients were capable of inducing the appearance of anti-Id-blocked, hapten-augmentable PFC in the lymphocyte population from 2-month-old donors. Thus, the results of this study indicate syner-gistic co-operation between B lymphocytes and thymus cells from old donors for the production of auto-anti-idiotypic antibody regulation with age. This production of auto-anti-Id antibody with age seems not to be an induced maturation event but perhaps an intrinsic property unique to lymphocytes from old donors.

Control of primary IgM antibody responses to H-2 alloantigens by antigen-bearing live B lymphocytes

1982 ◽  
Vol 12 (9) ◽  
pp. 713-719 ◽  
Author(s):  
Izumi Nakashima ◽  
Kenji Mizoguchi ◽  
Nobuo Kato ◽  
Fumihiko Nagase ◽  
Ken-Ichi Isobe ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Antibody Responses ◽  
Igm Antibody

Abzyme generation using an anti-idiotypic antibody as the “internal image” of an enzyme active site

1994 ◽  
Vol 47 (2-3) ◽  
pp. 229-239 ◽  
Author(s):  
Alain Friboulet ◽  
Ladan Izadyar ◽  
Berangere Avalle ◽  
Alberto Roseto ◽  
Daniel Thomas
Keyword(s):  
Active Site ◽  
Enzyme Active Site ◽  
Internal Image ◽  
Idiotypic Antibody

scholarly journals The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

1978 ◽  
Vol 148 (4) ◽  
pp. 878-889 ◽  
Author(s):  
B M Hall ◽  
S Dorsch ◽  
B Roser
Keyword(s):  
T Cells ◽  
B Lymphocytes ◽  
Adoptive Transfer ◽  
Graft Rejection ◽  
Allograft Rejection ◽  
Adult Life ◽  
Transfer System ◽  
Heart Graft ◽  
Rapid Appearance

The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.

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