PROTEIN KINASE C PATHWAY IS INVOLVED IN REGULATING THE SECRETION OF PROSTATIC ACID PHOSPHATASE IN HUMAN PROSTATE CANCER CELLS

2001 ◽  
Vol 25 (11) ◽  
pp. 1139-1148 ◽  
Author(s):  
M Lin
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase C ◽  
Acid Phosphatase ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Prostatic Acid Phosphatase ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Kinase C

scholarly journals Effects of the Antiandrogen Flutamide on the Expression of Protein Kinase C Isoenzymes in LNCaP and PC3 Human Prostate Cancer Cells

2004 ◽  
Vol 24 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Leire Montalvo ◽  
María J. Carmena ◽  
Oscar Bolaños ◽  
Nieves Rodríguez-Henche ◽  
Manuel Sánchez-Chapado ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Cultured Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Kinase C ◽  
Pc3 Cells

Flutamide is a nonsteroidal antiandrogen that is frequently used for total androgen blockage in the treatment of advanced prostate cancer. We investigated the effect of this antiandrogen on the expression of protein kinase C (PKC) isoenzymes (α, β1, ∊, ζ) that are involved in cell growth, apoptosis and neoplastic transformation. Androgen-dependent (LNCaP) and independent (PC3) human prostate cancer cells were cultured in a medium that contained fetal bovine serum (FBS) or charcoal-stripped serum (CSS) and treated with 10 μM flutamide. The expression of PKC isoenzymes and the androgen receptor (AR) were analyzed by Western blot and RT-PCR, respectively. Serum steroids differentially regulate the expression of PKC isoenzymes in LNCaP and PC3 cells. Flutamide up-regulated the expression of α, β1 and ζ, but not ∊, PKC isoenzymes in CSS-LNCaP cells. These results were not homogeneously reproduced in the presence of androgens. We observed an opposite effect of flutamide, compared to CSS, on PKCβ1 isoform expression in CSS-LNCaP suggesting that this antiandrogen exerts an agonistic effect. In PC3 cells flutamide potentiated the expression of the four PKC isoenzymes in almost all conditions tested (FBS- and CSS-cultured cells). Such effect of flutamide in PC3 cells is independent of AR since no expression of AR was detected. These results provide new evidence on antagonistic/agonistic responses of prostate cancer cells to antiandrogen drugs that are widely used in therapy and show that flutamide can elicit responses in prostate cancer cells that do not express AR.

DECREASED EXPRESSION OF CELLULAR PROSTATIC ACID PHOSPHATASE INCREASES TUMORIGENICITY OF HUMAN PROSTATE CANCER CELLS

2001 ◽  
Vol 166 (5) ◽  
pp. 1943-1950 ◽  
Author(s):  
MING-FONG LIN ◽  
MING-SHYUE LEE ◽  
XIAO-WEI ZHOU ◽  
JOHN C. ANDRESSEN ◽  
TZU-CHING MENG ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Acid Phosphatase ◽  
Cancer Cells ◽  
Prostatic Acid Phosphatase ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Conjugated Linoleic Acid Inhibits Proliferation and Modulates Protein Kinase C Isoforms in Human Prostate Cancer Cells

2004 ◽  
Vol 49 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Hyun-Ju Song ◽  
Alan A. Sneddon ◽  
Pamela A. Barker ◽  
Charles Bestwick ◽  
Sun-Nam Choe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase C ◽  
Linoleic Acid ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Conjugated Linoleic Acid ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Kinase C ◽  
Protein Kinase C Isoforms

scholarly journals Protein kinase Cɛ interacts with Bax and promotes survival of human prostate cancer cells

Oncogene ◽  
2003 ◽  
Vol 22 (39) ◽  
pp. 7958-7968 ◽  
Author(s):  
Meagan A McJilton ◽  
C Van Sikes ◽  
Ginger G Wescott ◽  
Daqing Wu ◽  
Tonia L Foreman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Protein Kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells

2013 ◽  
Vol 228 (6) ◽  
pp. 1159-1165 ◽  
Author(s):  
Hyo-Kyoung Choi ◽  
Jung-Yoon Yoo ◽  
Mi-Hyeon Jeong ◽  
Soo-Yeon Park ◽  
Dong-Myoung Shin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Cancer Cells ◽  
Nuclear Translocation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Kinase A
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