SAW PALMETTO BERRY EXTRACT INHIBITS CELL GROWTH AND COX-2 EXPRESSION IN PROSTATIC CANCER CELLS

2001 ◽  
Vol 25 (11) ◽  
pp. 1117-1124 ◽  
Author(s):  
W Goldmann
Keyword(s):  
Cell Growth ◽  
Cancer Cells ◽  
Prostatic Cancer ◽  
Saw Palmetto ◽  
Cox 2

Polyamines and prostatic cancer

2003 ◽  
Vol 31 (2) ◽  
pp. 375-380 ◽  
Author(s):  
R.G. Schipper ◽  
J.C. Romijn ◽  
V.M.J.I. Cuijpers ◽  
A.A.J. Verhofstad
Keyword(s):  
Cell Growth ◽  
Cancer Cells ◽  
Ornithine Decarboxylase ◽  
Prostatic Cancer ◽  
Apoptotic Cell ◽  
Metabolic Enzymes ◽  
Human Prostate ◽  
In Vivo Model ◽  
Biological Behaviour ◽  
Polyamine Analogues

The importance of polyamines in prostatic growth and differentiation has prompted studies to evaluate the clinical relevance of the ornithine decarboxylase/polyamine system in prostatic cancer. These studies show that differences in biological behaviour of prostatic (cancer) cells are associated with changes in polyamine levels and/or the activity of their metabolic enzymes. Faulty antizyme regulation of polyamine homoeostasis may play an important role in the growth and progression of prostatic carcinoma. Treatment of human prostate carcinoma cells with inhibitors of polyamine metabolic enzymes or polyamine analogues induces cell growth arrest or (apoptotic) cell death. Our recent in vitro studies using conformationally restricted polyamine analogues show that these compounds inhibit cell growth, probably by inducing antizyme-mediated degradation of ornithine decarboxylase. Sensitivity of human prostate cancer cells for these compounds was increased in the absence of androgens. These results suggest that these analogues might have chemotherapeutic potential in case prostatic cancer has become androgen-independent. Pilot data in an in vivo model show that these analogues have effects on tumour cell proliferation, vascularity, blood perfusion and tissue hypoxia. Overall, these studies show that polyamines may serve as important biomarkers of prostatic malignancy and provide a promising target for chemotherapy of prostatic cancer.

scholarly journals Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells

2017 ◽  
Vol 51 (5) ◽  
pp. 1601-1610 ◽  
Author(s):  
Xin Wang ◽  
Chen Tan ◽  
Guo Wang ◽  
Jing-Jing Cai ◽  
Li-Ping Wang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cells ◽  
Prostatic Cancer ◽  
Dual Action

Effect of Leuprorelin Acetate on Cell Growth and Prostate-Specific Antigen Gene Expression in Human Prostatic Cancer Cells

1999 ◽  
Vol 35 (Suppl. 1) ◽  
pp. 2-8 ◽  
Author(s):  
Gigliola Sica ◽  
Fortunata Iacopino ◽  
Daniela Settesoldi ◽  
Giovanni Zelano
Keyword(s):  
Gene Expression ◽  
Cell Growth ◽  
Cancer Cells ◽  
Prostate Specific Antigen ◽  
Prostatic Cancer ◽  
Specific Antigen ◽  
Leuprorelin Acetate ◽  
Antigen Gene
Sign in / Sign up

Export Citation Format

Share Document