Th1 or Th2: How an Appropriate T Helper Response can be Made

2001 ◽  
Vol 63 (3) ◽  
pp. 405-431 ◽  
Author(s):  
C Bergmann
Keyword(s):  
T Helper ◽  
Helper Response ◽  
T Helper Response

Transient Detection of Plasma HIV-1 RNA During Postexposure Prophylaxis

2000 ◽  
Vol 21 (8) ◽  
pp. 529-531 ◽  
Author(s):  
Vincenzo Puro ◽  
Giuseppe Calcagno ◽  
Marco Anselmo ◽  
Gisella Benvenuto ◽  
Daria Trabattoni ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
T Helper ◽  
Postexposure Prophylaxis ◽  
Transient Detection ◽  
Helper Response ◽  
Antiretroviral Prophylaxis ◽  
Immunodeficiency Virus ◽  
Transient Plasma ◽  
Hiv 1 ◽  
T Helper Response

Transient plasma human immunodeficiency virus (HIV) copies were detected by nucleic-acid sequence-based amplification during combination antiretroviral prophylaxis in a healthcare worker who reported a percutaneous injury from a stylet and who remained HIV-antibody-negative. An HIV-specific T-helper response, assessed by interleukin-2 production, was observed when tested at 13 months following the exposure.

scholarly journals Self-Tolerance Does Not Restrict the CD4+ T-Helper Response against the p53 Tumor Antigen

2008 ◽  
Vol 68 (3) ◽  
pp. 893-900 ◽  
Author(s):  
Marjolein M. Lauwen ◽  
Sander Zwaveling ◽  
Linda de Quartel ◽  
S. Carmela Ferreira Mota ◽  
Janine A.C. Grashorn ◽  
...  
Keyword(s):  
Tumor Antigen ◽  
T Helper ◽  
Helper Response ◽  
Self Tolerance ◽  
T Helper Response

scholarly journals Comparative Analysis of Human Cytomegalovirus-Specific CD4+ T-Cell Frequency and Lymphoproliferative Response in Human Immunodeficiency Virus-Positive Patients

2001 ◽  
Vol 8 (6) ◽  
pp. 1225-1230 ◽  
Author(s):  
Giampiero Piccinini ◽  
Giuditta Comolli ◽  
Emilia Genini ◽  
Daniele Lilleri ◽  
Roberto Gulminetti ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
T Helper ◽  
Lymphoproliferative Response ◽  
Cell Frequency ◽  
Blood Samples ◽  
Helper Response ◽  
Immunodeficiency Virus ◽  
T Helper Response

ABSTRACT Evaluation of human cytomegalovirus (HCMV)-specific T-helper immunity could contribute in optimizing anti-HCMV therapy in human immunodeficiency virus (HIV)-infected patients. Testin the lymphoproliferative response (LPR) is the standard technique used to evaluate T-helper response, but its use in the routine diagnostic laboratory setting can be problematic. The most promising new alternative technique is the determination of HCMV-specific CD4+ T-cell frequency by flow cytometry detection of intracellular cytokine production after short-term antigen-specific activation of peripheral blood mononuclear cells. HCMV-specific LPR and CD4+ T-cell frequency were compared in a group of 78 blood samples from 65 HIV-infected patients. The results showed concordance in 80.7% of samples. In addition, comparative analysis of sequential blood samples from 13 HIV-infected patients showed that while in about half of patients the T-helper HCMV-specific immune response remained stable during highly active antiretroviral therapy (HAART), in the other half declining levels of the HCMV-specific CD4+-mediated immune response were determined by either one or both assays. In conclusion, our data suggest that the determination of HCMV-specific CD4+ T-cell frequency can be considered a valuable alternative to the LPR test for the detection of HCMV-specific T-helper response in HIV-infected patients. It could facilitate wider screening of anti-HCMV T-helper activity in HIV-infected patients, with potential benefits for clinicians in deciding strategies of discontinuation or maintenance of anti-HCMV therapy.

Defective T Helper Response of Hepatocyte-Stimulated CD4 T Cells Impairs Antiviral CD8 Response and Viral Clearance

2007 ◽  
Vol 133 (6) ◽  
pp. 2010-2018 ◽  
Author(s):  
Christiane Wiegard ◽  
Petra Wolint ◽  
Christian Frenzel ◽  
Uta Cheruti ◽  
Edgar Schmitt ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Viral Clearance ◽  
T Helper ◽  
Helper Response ◽  
T Helper Response

Elastin peptides modulate T helper response during murine emphysema

2015 ◽  
Author(s):  
Aïda Meghraoui-Kheddar ◽  
Mehdi Sellami ◽  
Sandra Audonnet ◽  
Moncef Guenounou ◽  
Richard Le Naour
Keyword(s):  
T Helper ◽  
Helper Response ◽  
T Helper Response

scholarly journals Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

1995 ◽  
Vol 14 (9) ◽  
pp. 1932-1941 ◽  
Author(s):  
I. Screpanti ◽  
L. Romani ◽  
P. Musiani ◽  
A. Modesti ◽  
E. Fattori ◽  
...  
Keyword(s):  
Lymphoproliferative Disorder ◽  
T Helper ◽  
Helper Response ◽  
Deficient Mice ◽  
T Helper Response
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