Ethanol Reduces rCFB Activation of Left Dorsolateral Prefrontal Cortex during a Verbal Fluency Task

2001 ◽  
Vol 77 (2) ◽  
pp. 197-215 ◽  
Author(s):  
Peter E. Wendt ◽  
Jarl Risberg
Keyword(s):  
Prefrontal Cortex ◽  
Verbal Fluency ◽  
Dorsolateral Prefrontal Cortex ◽  
Verbal Fluency Task ◽  
Dorsolateral Prefrontal ◽  
Fluency Task

scholarly journals Verbal Fluency in Mild Alzheimer’s Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex

2021 ◽  
pp. 1-11
Author(s):  
Daniela Smirni ◽  
Massimiliano Oliveri ◽  
Eliana Misuraca ◽  
Angela Catania ◽  
Laura Vernuccio ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Verbal Fluency ◽  
Dorsolateral Prefrontal Cortex ◽  
Control Group ◽  
Direct Current Stimulation ◽  
Cathodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (AD). Methods: Forty mild AD patients participated in the study (mean age 73.17±5.61 years). All participants underwent cognitive baseline tasks and a VFT twice. Twenty patients randomly received cathodal tDCS to the left or the right DLPFC, and twenty patients were assigned to a control group in which only the two measures of VFT were taken, without the administration of the tDCS. Results: A significant improvement of performance on the VFT in AD patients was present after tDCS over the right DLPFC (p = 0.001). Instead, no difference was detected between the two VFTs sessions after tDCS over the left DLPFC (p = 0.42). Furthermore, these results cannot be related to task learning effects, since no significant difference was found between the two VFT sessions in the control group (p = 0.73). Conclusion: These data suggest that tDCS over DLPFC can improve VFT performance in AD patients. A hypothesis is that tDCS enhances adaptive patterns of brain activity between functionally connected areas.

The activation of prefrontal cortex in Trail Making Test and Verbal Fluency Task

2011 ◽  
Vol 75 (0) ◽  
pp. 2AM057-2AM057
Author(s):  
Kazuhiro YASUNAGA ◽  
Toru YOSHIKAWA ◽  
Hiroyuki ITO ◽  
Hoshiko YAMAUCHI ◽  
Masayoshi OGURA ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Verbal Fluency ◽  
Trail Making Test ◽  
Verbal Fluency Task ◽  
Trail Making ◽  
Fluency Task

Dorsolateral prefrontal hemodynamic responses during a verbal fluency task in hypomanic bipolar disorder

2014 ◽  
Vol 17 (2) ◽  
pp. 172-183 ◽  
Author(s):  
Yukika Nishimura ◽  
Katsuyoshi Takahashi ◽  
Toshiyuki Ohtani ◽  
Reina Ikeda-Sugita ◽  
Kiyoto Kasai ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Verbal Fluency ◽  
Hemodynamic Responses ◽  
Verbal Fluency Task ◽  
Dorsolateral Prefrontal ◽  
Fluency Task

scholarly journals Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk

2000 ◽  
Vol 176 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Sean A. Spence ◽  
Peter F. Liddle ◽  
Martin D. Stefan ◽  
Jonathan S. E. Hellewell ◽  
Tonmoy Sharma ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Genetic Risk ◽  
Verbal Fluency ◽  
Dorsolateral Prefrontal Cortex ◽  
Functional Anatomy ◽  
Superior Temporal Gyrus ◽  
Anterior Cingulate ◽  
Left Dlpfc ◽  
Dorsolateral Prefrontal ◽  
Normal Controls

BackgroundPET studies of verbal fluency in schizophrenia report a failure of ‘deactivation’ of left superior temporal gyrus (STG) in the presence of activation of left dorsolateral prefrontal cortex (DLPFC), which deficit has been attributed to underlying ‘functional disconnectivity’.AimTo test whether these findings provide trait-markers for schizophrenia.MethodWe used H215O PET to examine verbal fluency in 10 obligate carriers of the predisposition to schizophrenia, 10 stable patients and 10 normal controls.ResultsWe found no evidence of a failure of left STG deactivation in carriers or patients. Instead, patients failed to deactivate the precuneus relative to other groups. We found no differences in functional connectivity between left DLPFC and left STG but patients exhibited significant disconnectivity between left DLPFC and anterior cingulate cortex.ConclusionsFailure of left STG ‘deactivation’ and left fronto-temporal disconnectivity are not consistent findings in schizophrenia; neither are they trait-markers for genetic risk. Prefrontal functional disconnectivity here may characterise the schizophrenic phenotype.

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