Different Activities of 5-Hydroxy-dUMP and 5-Hydroxymethyl-dUMP in Thymidylate Synthase-Catalyzed Reaction in View of Molecular Modeling and Structural Studies

2000 ◽  
Vol 28 (3) ◽  
pp. 156-162 ◽  
Author(s):  
Adam Jarmuła ◽  
Andrzej Leś ◽  
Wojciech Rode
Keyword(s):  
Molecular Modeling ◽  
Thymidylate Synthase ◽  
Structural Studies

scholarly journals Structural studies of coenzyme Q10 inclusion complex with g-cyclodextrin using chemical analyses and molecular modeling

2009 ◽  
Vol 9 ◽  
pp. 1-11 ◽  
Author(s):  
Shuichi Miyamoto ◽  
Akito Kawai ◽  
Shigesada Higuchi ◽  
Yuki Nishi ◽  
Toshiko Tanimoto ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Inclusion Complex ◽  
Coenzyme Q10 ◽  
Structural Studies ◽  
Chemical Analyses

Nuclear Magnetic Resonance Structural Studies and Molecular Modeling of Duplex DNA Containing Normal and 4‘-Oxidized Abasic Sites†,‡

Biochemistry ◽  
2007 ◽  
Vol 46 (11) ◽  
pp. 3096-3107 ◽  
Author(s):  
Jingyang Chen ◽  
François-Yves Dupradeau ◽  
David A. Case ◽  
Christopher J. Turner ◽  
JoAnne Stubbe
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Molecular Modeling ◽  
Magnetic Resonance ◽  
Duplex Dna ◽  
Structural Studies ◽  
Abasic Sites ◽  
Nuclear Magnetic

scholarly journals Molecular modeling and structural studies of 12-mer immobile four-way DNA junction in solution

2014 ◽  
Vol 10 (7) ◽  
pp. 394-400 ◽  
Author(s):  
Ramesh Kumar Yadav ◽  
◽  
Umesh Yadava ◽  
Keyword(s):  
Molecular Modeling ◽  
Structural Studies

scholarly journals Structural studies on ligand binding ability of Siglec-2 using molecular modeling techniques

2018 ◽  
Vol 15 ◽  
pp. 51-59
Author(s):  
Madhumita Dandopath Patra ◽  
Keyword(s):  
Signal Transduction ◽  
Molecular Modeling ◽  
Sialic Acids ◽  
Primary Role ◽  
Structural Studies ◽  
Binding Ability ◽  
Functional Roles ◽  
Modeling Techniques ◽  
Attractive Therapeutic Target

Siglecs are attractive therapeutic target of the major homologous subfamily of I-type lectins. The primary role of Siglecs may actually lie in the recognition and phagocytosis of bacterial pathogens that express sialic acids, maintenance of myelin organization, and inhibition of neurite outgrowth, cell-cell interactions between neurons and glial cells etc. Siglec-2, a member of the Siglec family expressed on the surface of maturing B cells and B cell lymphomas and regulates signal transduction. In this work, 3-D structure of human Siglec-2 was predicted using molecular modeling techniques. The structure of the complex in solution of Siglec-2 with ligand, 6′-Sialyl-N-acetyl lactose (6′-SialylLacNAc) was predicted using a novel docking technique. The structural analysis of the complex and calculation of theoretical dissociation constant value will help to ascertain functional roles of such sugar binding protein.

Structural Studies by1H NMR and Molecular Modeling of Peptide Substrates of Thermolysin in Relation with its Proteasic Activity in Water and Glycerol

1999 ◽  
Vol 16 (5) ◽  
pp. 1061-1074
Author(s):  
S. Baltora-Rosset ◽  
A. Aboubeker ◽  
F.-Y. Dupradeau ◽  
E. Pauthe ◽  
G.-A. Gacel ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Structural Studies ◽  
Peptide Substrates

Interaction of thymidylate synthase with pyridoxal 5'-phosphate as studied by UV/visible difference spectroscopy and molecular modeling

Biochemistry ◽  
1993 ◽  
Vol 32 (44) ◽  
pp. 11819-11824 ◽  
Author(s):  
Daniel V. Santi ◽  
Tian Mei Ouyang ◽  
Anthony K. Tan ◽  
Donald H. Gregory ◽  
Thomas Scanlan ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Thymidylate Synthase ◽  
Difference Spectroscopy ◽  
Uv Visible
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