The ATP Binding Cassette Transporter A1 Contributes to the Secretion of Interleukin 1β from Macrophages but Not from Monocytes

2002 ◽  
Vol 291 (3) ◽  
pp. 598-604 ◽  
Author(s):  
Xiaoqin Zhou ◽  
Thomas Engel ◽  
Christian Goepfert ◽  
Michael Erren ◽  
Gerd Assmann ◽  
...  
Keyword(s):  
Interleukin 1Β ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

ATP binding cassette transporter ABC1 is required for the release of interleukin-1β by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells

Glia ◽  
2004 ◽  
Vol 49 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Vincent Marty ◽  
Chantal Médina ◽  
Chantal Combe ◽  
Patricia Parnet ◽  
Thierry Amédée
Keyword(s):  
Schwann Cells ◽  
Interleukin 1Β ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Primed Mouse ◽  
Atp Binding Cassette

scholarly journals Interleukin-1β Secretion Is Impaired by Inhibitors of the Atp Binding Cassette Transporter, ABC1

Blood ◽  
1997 ◽  
Vol 90 (8) ◽  
pp. 2911-2915 ◽  
Author(s):  
Yannick Hamon ◽  
Marie-Françoise Luciani ◽  
Frederic Becq ◽  
Bernard Verrier ◽  
Anna Rubartelli ◽  
...  
Keyword(s):  
Abc Transporters ◽  
Anion Exchanger ◽  
Oral Therapy ◽  
Interleukin 1Β ◽  
Secretory Proteins ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
The Family ◽  
Mouse Macrophages ◽  
Atp Binding Cassette

Abstract The production of interleukin-1β (IL-1β), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1β. Because of the heavy side effects of most therapies used in IL-1β–mediated pathologies, a goal of pharmacologic research is the development of selective anti–IL-1β drugs. We show here that the sulfonylurea glyburide, currently used in the oral therapy of noninsulin dependent diabetes, is an inhibitor of IL-1β secretion from human monocytes and mouse macrophages. Glyburide reduces dramatically the recovery of extracellular 17-kD IL-1β in the absence of toxic effects on the cells and without affecting the synthesis or processing of the IL-1β precursor. IL-1β belongs to the family of leaderless secretory proteins released from the cell by a nonclassical secretory route. In bacteria and yeast Atp binding cassette (ABC) transporters are involved in the secretion of leaderless secretory proteins. Interestingly, glyburide blocks the anion exchanger function of ABC1, a mammalian member of the family of ABC transporters. We thus investigated the involvement of ABC1 in IL-1β secretion, through the analysis of the effects of drugs known to inhibit IL-1β secretion, on the activity of ABC1 and in turn the ability of known inhibitors of ABC1 of blocking IL-1β secretion. Our data show that IL-1β secretion and the function of ABC1 as an anion exchanger are sensitive to the same drugs, therefore suggesting an involvement of the ABC1 transporter in the secretion of leaderless proteins in mammals.

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