Expression of Fc α/μ Receptor by Human Mesangial Cells: A Candidate Receptor for Immune Complex Deposition in IgA Nephropathy

2002 ◽  
Vol 290 (1) ◽  
pp. 438-442 ◽  
Author(s):  
Kenneth J. McDonald ◽  
Angus J.M. Cameron ◽  
Janet M. Allen ◽  
Alan G. Jardine
Keyword(s):  
Iga Nephropathy ◽  
Immune Complex ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Μ Receptor

Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice

2012 ◽  
Vol 110 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Hyojung Lee ◽  
Hyunseong Kim ◽  
Gihyun Lee ◽  
Hwan-Suck Chung ◽  
Hyunsu Bae
Keyword(s):  
New Zealand ◽  
Lupus Nephritis ◽  
Immune Complex ◽  
Serum Levels ◽  
Therapeutic Effects ◽  
Igg Antibodies ◽  
Renal Inflammation ◽  
Female Mice ◽  
Immune Complex Deposition ◽  
Complex Deposition

Curcumin has been used in Asian traditional medicine for its medicinal properties. Recent studies have demonstrated that curcumin has antioxidant, anti-tumour and anti-inflammatory activities. The aim of the present study is to investigate the effects of curcumin on established lupus nephritis (LN) in New Zealand Black/White (NZB/W) F1 female mice, in particular, its interaction with regulatory T (Treg) cells. Starting at 18 weeks of age, mice were fed a standard diet or a diet containing 1 % curcumin until the end of the study. The proteinuria level and the serum levels of IgG1, IgG2a and anti-double-stranded DNA (dsDNA) IgG antibodies were measured. Additionally, IgG immune complex deposition in the glomeruli and renal inflammation were compared between curcumin-treated mice and control mice. Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice. IgG immune complex deposition in the glomeruli was reduced in curcumin-treated mice. Furthermore, renal inflammation was also decreased after curcumin treatment. Interestingly, these therapeutic effects of curcumin disappeared after Treg depletion by anti-CD25 antibody injection. Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells.

scholarly journals IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells

2011 ◽  
Vol 26 (11) ◽  
pp. 3451-3457 ◽  
Author(s):  
Jan Novak ◽  
Leona Raskova Kafkova ◽  
Hitoshi Suzuki ◽  
Milan Tomana ◽  
Karel Matousovic ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Pediatric Patients ◽  
Mesangial Cells ◽  
Human Mesangial Cells

Immune complex deposition in Bowman's capsule is associated with parietal podocytes

1994 ◽  
Vol 173 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Ian W. Gibson ◽  
Thomas T. Downie ◽  
Ian A. R. More ◽  
George B. M. Lindop
Keyword(s):  
Immune Complex ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Bowman's Capsule
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