Inhibitors of Fibril Formation and Cytotoxicity of β-Amyloid Peptide Composed of KLVFF Recognition Element and Flexible Hydrophilic Disrupting Element

2002 ◽  
Vol 290 (1) ◽  
pp. 121-124 ◽  
Author(s):  
Ken-ichi Watanabe ◽  
Kazuhiko Nakamura ◽  
Shingo Akikusa ◽  
Tomoko Okada ◽  
Masato Kodaka ◽  
...  
Keyword(s):  
Fibril Formation ◽  
Amyloid Peptide ◽  
Recognition Element ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Inhibition of fibril formation in β-amyloid peptide by a novel series of benzofurans

1999 ◽  
Vol 340 (1) ◽  
pp. 283 ◽  
Author(s):  
David R. HOWLETT ◽  
Amanda E. PERRY ◽  
Fiona GODFREY ◽  
Jane E. SWATTON ◽  
Kevin H. JENNINGS ◽  
...  
Keyword(s):  
Fibril Formation ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Glutamine Synthetase-Induced Enhancement of β-Amyloid Peptide Aβ(1-40) Neurotoxicity Accompanied by Abrogation of Fibril Formation and Aβ Fragmentation

2002 ◽  
Vol 66 (5) ◽  
pp. 2050-2056 ◽  
Author(s):  
M. Y. Aksenov ◽  
M. V. Aksenova ◽  
D. A. Butterfield ◽  
K. Hensley ◽  
C. Vigo-Pelfrey ◽  
...  
Keyword(s):  
Glutamine Synthetase ◽  
Fibril Formation ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Inhibition of fibril formation in β-amyloid peptide by a novel series of benzofurans

1999 ◽  
Vol 340 (1) ◽  
pp. 283-289 ◽  
Author(s):  
David R. HOWLETT ◽  
Amanda E. PERRY ◽  
Fiona GODFREY ◽  
Jane E. SWATTON ◽  
Kevin H. JENNINGS ◽  
...  
Keyword(s):  
Binding Assay ◽  
Close Correlation ◽  
Fibril Formation ◽  
Biologically Active ◽  
Amyloid Peptide ◽  
Binding Assays ◽  
Nmr Studies ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Self Aggregation

A series of benzofuran derivatives have been identified as inhibitors of fibril formation in the β-amyloid peptide. The activity of these compounds has been assessed by a novel fibril-formation-specific immunoassay and for their effects on the production of a biologically active fibril product. The inhibition afforded by the compounds seems to be associated with their binding to β-amyloid, as identified by scintillation proximity binding assay. Binding assays and NMR studies also indicate that the inhibition is associated with self-aggregation of the compounds. There is a close correlation between the activity of the benzofurans as inhibitors of fibril formation and their ability to bind to β-amyloid. Non-benzofuran inhibitors of the fibril formation process do not seem to bind to the same site on the β-amyloid molecule as the benzofurans. Thus a specific recognition site might exist for benzofurans on β-amyloid, binding to which seems to interfere with the ability of the peptide to form fibrils.

scholarly journals Polymorphic Fibril Formation by Residues 10–40 of the Alzheimer’s β-Amyloid Peptide

2006 ◽  
Vol 90 (12) ◽  
pp. 4618-4629 ◽  
Author(s):  
Anant K. Paravastu ◽  
Aneta T. Petkova ◽  
Robert Tycko
Keyword(s):  
Fibril Formation ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Amyloid Fibril Formation by Aβ16-22, a Seven-Residue Fragment of the Alzheimer's β-Amyloid Peptide, and Structural Characterization by Solid State NMR†

Biochemistry ◽  
2000 ◽  
Vol 39 (45) ◽  
pp. 13748-13759 ◽  
Author(s):  
John J. Balbach ◽  
Yoshitaka Ishii ◽  
Oleg N. Antzutkin ◽  
Richard D. Leapman ◽  
Nancy W. Rizzo ◽  
...  
Keyword(s):  
Solid State ◽  
Structural Characterization ◽  
Solid State Nmr ◽  
Amyloid Fibril ◽  
Fibril Formation ◽  
Amyloid Peptide ◽  
Amyloid Fibril Formation ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals α2-Macroglobulin Attenuates β-Amyloid Peptide 1-40 Fibril Formation and Associated Neurotoxicity of Cultured Fetal Rat Cortical Neurons

2002 ◽  
Vol 70 (3) ◽  
pp. 1182-1188 ◽  
Author(s):  
Yansheng Du ◽  
Kelly R. Bales ◽  
Richard C. Dodel ◽  
Xiaodong Liu ◽  
Michele A. Glinn ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Fibril Formation ◽  
Amyloid Peptide ◽  
Fetal Rat ◽  
Α2 Macroglobulin ◽  
Rat Cortical Neurons ◽  
Β Amyloid ◽  
Β Amyloid Peptide
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