Fibroblast Growth Factor 5 Inhibits Hair Growth by Blocking Dermal Papilla Cell Activation

2002 ◽  
Vol 290 (1) ◽  
pp. 169-176 ◽  
Author(s):  
Yutaka Ota ◽  
Yuko Saitoh ◽  
Satoshi Suzuki ◽  
Kazuo Ozawa ◽  
Mitsuko Kawano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Cell Activation ◽  
Dermal Papilla ◽  
Fibroblast Growth ◽  
Dermal Papilla Cell

scholarly journals CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

Genes ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 297 ◽  
Author(s):  
Yuxin Xu ◽  
Hongmei Liu ◽  
Huilin Pan ◽  
Xinyue Wang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Negative Regulator ◽  
Fibroblast Growth ◽  
Hair Cycle ◽  
Ideal Model ◽  
Anagen Phase ◽  
Hematoxylin And Eosin ◽  
Scanning Electron

Hair growth and morphology are generally regulated by the hair cycle in mammals. Fibroblast Growth Factor 5 (FGF5), which is a hair cycle regulator, has a role in regulating the hair cycle during the transition from the anagen phase to the catagen phase, and a hereditary long hair phenotype has been widely reported when FGF5 is mutated in humans and other species. However, there has been no such report in rabbits. Thus, the first exon of rabbit FGF5 was disrupted by the CRISPR/Cas9 system, and the phenotype of FGF5-/- rabbits was characterized while using hematoxylin and eosin (H&E) staining, immunohistochemistry, quantitative PCR, scanning electron microscopy, and western blotting. The results showed a significant and systemic long hair phenotype in the FGF5-/- rabbits, which indicated that FGF5 is a negative regulator of hair growth. In addition, a decreased diameter of the fiber and a higher area proportion of hair follicle clusters were determined in FGF5-/- rabbits as compared with the WT rabbits. Further investigation verified that prolonging the anagen phase in rabbits, with decreased BMP2/4 pathway signaling and increased VERSICAN pathway signaling, caused the systemic long hair phenotype. Taken together, these results indicate a systemic long hair phenotype by prolonging anagen in FGF5-/- rabbits, which could be widely used for Fur production and an ideal model for studying the mechanism of long hair in the future.

scholarly journals Fibroblast Growth Factor-9 Activates c-Kit Progenitor Cells and Enhances Angiogenesis in the Infarcted Diabetic Heart

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Dinender Singla ◽  
Jing Wang
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Progenitor Cells ◽  
Cell Activation ◽  
Left Ventricular ◽  
Diabetic Heart ◽  
Fibroblast Growth ◽  
Sham Surgery ◽  
Left Ventricular Output ◽  
Fractional Shortening

We hypothesized that fibroblast growth factor-9 (FGF-9) would enhance angiogenesis via activating c-kit positive stem cells in the infarcted nondiabetic and diabetic heart. In brief, animals were divided into three groups: Sham, MI, and MI+FGF-9. Two weeks following MI or sham surgery, our data suggest that treatment with FGF-9 significantly diminished vascular apoptosis compared to the MI group in both C57BL/6 and db/db mice (p<0.05). Additionally, the number of c-kit+ve/SMα-actin+vecells and c-kit+ve/CD31+vecells were greatly enhanced in the MI+FGF-9 groups relative to the MI suggesting FGF-9 enhances c-Kit cell activation and their differentiation into vascular smooth muscle cells and endothelial cells, respectively (p<0.05). Histology shows that the total number of vessels were quantified for all groups and our data suggest that the FGF-9 treated groups had significantly more vessels than their MI counterparts (p<0.05). Finally, echocardiographic data suggests a significant improvement in left ventricular output, as indicated by fractional shortening and ejection fraction in both nondiabetic and diabetic animals treated with FGF-9 (p<0.05). Overall, our data suggests FGF-9 has the potential to attenuate vascular cell apoptosis, activate c-Kit progenitor cells, and enhance angiogenesis and neovascularization in C57BL/6 and db/db mice leading to improved cardiac function.

Decapeptide with fibroblast growth factor (FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5

2003 ◽  
Vol 197 (2) ◽  
pp. 272-283 ◽  
Author(s):  
Chikako Ito ◽  
Yuko Saitoh ◽  
Yasuko Fujita ◽  
Yoshimitsu Yamazaki ◽  
Toru Imamura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Partial Sequence ◽  
Fibroblast Growth

scholarly journals Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wei-hong Lin ◽  
Li-Jun Xiang ◽  
Hong-Xue Shi ◽  
Jian Zhang ◽  
Li-ping Jiang ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Hair Follicles ◽  
Control Group ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Anagen Phase ◽  
Growth Promoting

Growth factors are involved in the regulation of hair morphogenesis and cycle hair growth. The present study sought to investigate the hair growth promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action. We observed that FGFs promoted hair growth by inducing the anagen phase in telogenic C57BL/6 mice. Specifically, the histomorphometric analysis data indicates that topical application of FGFs induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to the control group. Moreover, the immunohistochemical analysis reveals earlier induction ofβ-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group. These results suggest that FGFs promote hair growth by inducing the anagen phase in resting hair follicles and might be a potential hair growth-promoting agent.

scholarly journals Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth

2016 ◽  
pp. 127 ◽  
Author(s):  
Yuki Takabayashi ◽  
Masaki Nambu ◽  
Masayuki Ishihara ◽  
Masahiro Kuwabara ◽  
Koichi Fukuda ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth
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