Requirement of c-Jun N-Terminal Kinase for Apoptotic Cell Death Induced by Farnesyltransferase Inhibitor, Farnesylamine, in Human Pancreatic Cancer Cells

2001 ◽  
Vol 288 (1) ◽  
pp. 198-204 ◽  
Author(s):  
Yusuke Mizukami ◽  
Hitoshi Ura ◽  
Takeshi Obara ◽  
Atsuya Habiro ◽  
Tsutomu Izawa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Pancreatic Cancer ◽  
Farnesyltransferase Inhibitor ◽  
Pancreatic Cancer Cells

Blocking Angiotensin II Type 1 Receptor Triggers Apoptotic Cell Death in Human Pancreatic Cancer Cells

Pancreas ◽  
2010 ◽  
Vol 39 (5) ◽  
pp. 581-594 ◽  
Author(s):  
Qiaoke Gong ◽  
Molly Davis ◽  
Galina Chipitsyna ◽  
Charles J. Yeo ◽  
Hwyda A. Arafat
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Angiotensin Ii ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

P33. HSP70 Inhibition Sensitizes to Trail Induced Apoptotic Cell Death in Pancreatic Cancer Cells

2008 ◽  
Vol 144 (2) ◽  
pp. 448
Author(s):  
Daniel Borja-Cacho ◽  
Pawel Zwolak ◽  
Vikas Dudeja ◽  
Rajinder K. Dawra ◽  
Jacob S. Ankeny ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Pancreatic Cancer Cells

QS308. HSP70 Inhibition Sensitizes to TRAIL Induced Apoptotic Cell Death in Pancreatic Cancer Cells

2008 ◽  
Vol 144 (2) ◽  
pp. 389
Author(s):  
Daniel Borja-Cacho ◽  
Pawel Zwolak ◽  
Vikas Dudeja ◽  
Rajinder K. Dawra ◽  
Jacob S. Ankeny ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Pancreatic Cancer Cells

Plumbagin, Isolated from Plumbago zeylanica, Induces Cell Death through Apoptosis in Human Pancreatic Cancer Cells

Pancreatology ◽  
2009 ◽  
Vol 9 (6) ◽  
pp. 797-809 ◽  
Author(s):  
Chien-An Chen ◽  
Hen-Hong Chang ◽  
Chung-Yu Kao ◽  
Tung-Hu Tsai ◽  
Yu-Jen Chen
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Plumbago Zeylanica ◽  
Pancreatic Cancer Cells

Inhibition of Growth and Invasive Activity of Human Pancreatic Cancer Cells by a Farnesyltransferase Inhibitor, Manumycin

Pancreas ◽  
1997 ◽  
Vol 15 (4) ◽  
pp. 379-383 ◽  
Author(s):  
Osamu Kainuma ◽  
Takehide Asano ◽  
Masayuki Hasegawa ◽  
Takashi Kenmochi ◽  
Toshio Nakagohri ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Farnesyltransferase Inhibitor ◽  
Inhibition Of Growth ◽  
Pancreatic Cancer Cells

scholarly journals Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4173
Author(s):  
Faustino Mollinedo ◽  
Consuelo Gajate
Keyword(s):  
Pancreatic Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Er Stress ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Apoptotic Cell ◽  
Ether Lipid ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, shows a dismal and grim overall prognosis and survival rate, which have remained virtually unchanged for over half a century. PDAC is the most lethal of all cancers, with the highest mortality-to-incidence ratio. PDAC responds poorly to current therapies and remains an incurable malignancy. Therefore, novel therapeutic targets and drugs are urgently needed for pancreatic cancer treatment. Selective induction of apoptosis in cancer cells is an appealing approach in cancer therapy. Apoptotic cell death is highly regulated by different signaling routes that involve a variety of subcellular organelles. Endoplasmic reticulum (ER) stress acts as a double-edged sword at the interface of cell survival and death. Pancreatic cells exhibit high hormone and enzyme secretory functions, and thereby show a highly developed ER. Thus, pancreatic cancer cells display a prominent ER. Solid tumors have to cope with adverse situations in which hypoxia, lack of certain nutrients, and the action of certain antitumor agents lead to a complex interplay and crosstalk between ER stress and autophagy—the latter acting as an adaptive survival response. ER stress also mediates cell death induced by a number of anticancer drugs and experimental conditions, highlighting the pivotal role of ER stress in modulating cell fate. The alkylphospholipid analog prototype edelfosine is selectively taken up by tumor cells, accumulates in the ER of a number of human solid tumor cells—including pancreatic cancer cells—and promotes apoptosis through a persistent ER-stress-mediated mechanism both in vitro and in vivo. Here, we discuss and propose that direct ER targeting may be a promising approach in the therapy of pancreatic cancer, opening up a new avenue for the treatment of this currently incurable and deadly cancer. Furthermore, because autophagy acts as a cytoprotective response to ER stress, potentiation of the triggering of a persistent ER response by combination therapy, together with the use of autophagy blockers, could improve the current gloomy expectations for finding a cure for this type of cancer.

Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy

Planta Medica ◽  
2015 ◽  
Vol 81 (10) ◽  
pp. 838-846 ◽  
Author(s):  
Masayuki Fukui ◽  
Noriko Yamabe ◽  
Hye-Joung Choi ◽  
Kishore Polireddy ◽  
Qi Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Beclin 1 ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells
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