Matrix Metalloproteinase-2 and -9 in Bile as a Marker of Liver Metastasis in Colorectal Cancer

2001 ◽  
Vol 288 (1) ◽  
pp. 212-216 ◽  
Author(s):  
Norimichi Okada ◽  
Hideyuki Ishida ◽  
Nobuo Murata ◽  
Daijo Hashimoto ◽  
Yousuke Seyama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2

Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis

2003 ◽  
Vol 90 (12) ◽  
pp. 1556-1564 ◽  
Author(s):  
E. T. Waas ◽  
T. Wobbes ◽  
R. M. L. M. Lomme ◽  
J. DeGroot ◽  
T. Ruers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Colorectal Cancer Liver Metastasis

Carcinoembryonic antigen and matrix metalloproteinase 2 serum and peritoneal washes concentration in staging and prognosis in colorectal cancer patients

2018 ◽  
Vol 90 (5) ◽  
pp. 36-43
Author(s):  
Tomasz Guzel ◽  
Dagmara Mirowska-Guzel ◽  
Gustaw Lech ◽  
Marek Wroński ◽  
Marzena Iwanowska ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Matrix Metalloproteinase ◽  
Tumor Staging ◽  
Statistical Significance ◽  
Matrix Metalloproteinase 2 ◽  
Curative Surgery ◽  
P Concentration ◽  
Preoperative Serum ◽  
Significant Difference

Abstract Purpose: The aim of the study was to determine of carcinoembryonal antigen and matrix metalloproteinase 2 peritoneal washes and serum concentration in patients suffering from colorectal cancer concerning tumor staging and 5-year survival rate in these patients. Methods: 80 patients who underwent curative surgery for colorectal cancer were included into the study. Preoperative serum and intraoperative peritoneal washes CEA and MMP-2 concentrations were measured. Results: Concerning tumor penetration CEA-s and CEA-p concentration was higher in subsequent stages from T2 to T4. Both CEA-s and CEA-p concentration was lower in T2 comparing to T3 and T4. Significant difference of CEA-s and CEA-p was noted between T2 and T4 stages. MMP2-s concentration was higher in T3 comparing to T2, the highest MMP2-p concentration was in T4, with no statistical significance. Concerning nodular status significant difference of CEA-s was noted between N0 and N1. For CEA-p significance was found between N0 and N2 as between N1 and N2. MMP2-s concentration was the highest in N1, MMP2-p concentration was the highest in T4, with no statistical significance. 5-year survival rate for all patients was 63,53%. There were significant differences in CEA-s and CEA-p concentration between patients with negative and positive 5-year survival. Conclusion: Intraoperative peritoneal washes concentration of CEA may potentially serve as an important factor for more precise colorectal cancer staging. CEA-p and CEA-s concentration correlates with survival rate in patients suffering from colorectal cancer and can be useful as an additional prognostic factor. Usefulness of MMP2 measurement still requires further studies.

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